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UniProtKB/Swiss-Prot entry Q9Y5T4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DJC15_HUMAN
Primary accession number Q9Y5T4
Secondary accession numbers Q5T219 Q6X963
Integrated into Swiss-Prot on July 25, 2006
Sequence was last modified on July 25, 2006 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 60)
Name and origin of the protein
Protein name DnaJ homolog subfamily C member 15
Synonyms Methylation-controlled J protein
MCJ
Cell growth-inhibiting gene 22 protein
Gene name
Name: DNAJC15
Synonyms: DNAJD1
ORFNames: GIG22, HSD18
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT GLY-35.
PubMed=11358853 [NCBI, ExPASy, EBI, Israel, Japan]
Shridhar V., Bible K.C., Staub J., Avula R., Lee Y.K., Kalli K., Huang H., Hartmann L.C., Kaufmann S.H., Smith D.I.;
"Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer.";
Cancer Res. 61:4258-4265(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.;
"A new spermatogenesis-related gene.";
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kim J.W.;
"Identification of a cell growth inhibiting gene.";
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02379; PubMed=15057823 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
"The DNA sequence and analysis of human chromosome 13.";
Nature 428:522-528(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-35.
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF126743; AAD38506.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY248898; AAP20049.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY512565; AAS80157.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL445217; CAI13480.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010910; AAH10910.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC095400; AAH95400.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00001649; -.
RefSeq NP_037370.2; -.
UniGene Hs.438830
3D structure databases
ModBase Q9Y5T4.
PTM databases
PhosphoSite Q9Y5T4; -.
Organism-specific databases
GeneCards GC13P042496; -.
H-InvDB HIX0011275; -.
HGNC HGNC:20325; DNAJC15.
GenAtlas DNAJC15.
HPA HPA007988; -.
PharmGKB PA134932264; -.
Gene expression databases
ArrayExpress Q9Y5T4; -.
Bgee Q9Y5T4; -.
CleanEx HS_DNAJC15; -.
GermOnline ENSG00000120675; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from HPA).
GO:0005925; Cellular component: focal adhesion (inferred from direct assay from HPA).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005634; Cellular component: nucleus (inferred from direct assay from HPA).
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
Graphical view of domain structure.
Pfam PF00226; DnaJ; 1.
Pfam graphical view of domain structure.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; FALSE_NEG.
PS50076; DNAJ_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9Y5T4; -.
Genome annotation databases
Ensembl ENSG00000120675; Homo sapiens. [Contig view]
GeneID 29103; -.
KEGG hsa:29103; -.
NMPDR fig|9606.3.peg.8795; -.
Phylogenomic databases
HOGENOM Q9Y5T4; -.
HOVERGEN Q9Y5T4; -.
OMA Q9Y5T4; EQVITET.
Other
NextBio 52147; -.
ProtoNet Q9Y5T4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chaperone; Membrane; Phosphoprotein; Polymorphism; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   150  150     DnaJ homolog subfamily C member 15. PRO_0000247139
TRANSMEM   35    57  23     Potential. 
DOMAIN   96   150  55     J. 
MOD_RES   104   104        Phosphoserine. 
VARIANT   35    35  1     R -> G (in dbSNP:rs11617079 [NCBI]). VAR_027077 
CONFLICT   34    34        Q -> R (in Ref. 2; AAP20049). 
CONFLICT   131   131        P -> S (in Ref. 2; AAP20049). 
Sequence information
Length: 150 AA [This is the length of the unprocessed precursor] Molecular weight: 16383 Da [This is the MW of the unprocessed precursor] CRC64: 988059B686D39967 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAARGVIAPV GESLRYAEYL QPSAKRPDAD VDQQRLVRSL IAVGLGVAAL AFAGRYAFRI 

        70         80         90        100        110        120 
WKPLEQVITE TAKKISTPSF SSYYKGGFEQ KMSRREAGLI LGVSPSAGKA KIRTAHRRVM 

       130        140        150 
ILNHPDKGGS PYVAAKINEA KDLLETTTKH 

Q9Y5T4 in FASTA format

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