[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Testis; DOI=10.1093/hmg/8.6.989; PubMed=10332030 [NCBI, ExPASy, EBI, Israel, Japan] Raymond C.S., Parker E.D., Kettlewell J.R., Brown L.G., Page D.C., Kusz K., Jaruzelska J., Reinberg Y., Flejter W.L., Bardwell V.J., Hirsch B., Zarkower D.; "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators."; Hum. Mol. Genet. 8:989-996(1999).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Kidney; DOI=10.1006/geno.2000.6120; PubMed=10729224 [NCBI, ExPASy, EBI, Israel, Japan] Ottolenghi C., Veitia R., Barbieri M., Fellous M., McElreavey K.; "The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript."; Genomics 64:179-186(2000).
[3]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Kidney; DOI=10.1006/geno.2000.6160; PubMed=10857744 [NCBI, ExPASy, EBI, Israel, Japan] Calvari V., Bertini V., De Grandi A., Peverali G., Zuffardi O., Ferguson-Smith M., Knudtzon J., Camerino G., Borsani G., Guioli S.; "A new submicroscopic deletion that refines the 9p region for sex reversal."; Genomics 65:203-212(2000).

Comments

SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Expressed in testis, kidney and skeletal muscle.
SIMILARITY: Belongs to the DMRT family.
SIMILARITY: Contains 1 DM DNA-binding domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF130729; AAD40475.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Y19052; CAB59891.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF284223; AAF86291.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF284224; AAF86293.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00001732; -.

RefSeq

NP_001124337.1; -.
NP_006548.1; -.
NP_870987.2; -.

UniGene

Hs.59506

3D structure databases

HSSP

P23023; 1LPV. [HSSP ENTRY / PDB]

ModBase

Q9Y5R5.

Organism-specific databases

GC09P001040; -.

HIX0025707; -.

HGNC:2935; DMRT2.

604935; gene. [NCBI / EBI]

Orphanet

242; Gonadal dysgenesis, XY female type.

PharmGKB

PA27382; -.

Gene expression databases

Q9Y5R5; -.

Q9Y5R5; -.

HS_DMRT2; -.

ENSG00000173253; Homo sapiens.

Ontologies

GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003700;	Molecular function: transcription factor activity (traceable author statement from ProtInc).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008584;	Biological process: male gonad development (traceable author statement from ProtInc).
GO:0006355;	Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0007530;	Biological process: sex determination (traceable author statement from ProtInc).
GO:0006350;	Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001275; DM_DNA_bd.
Graphical view of domain structure.

Gene3D

G3DSA:4.10.1040.10; DM_DNA_bd; 1.

Pfam

PF00751; DM; 1.
Pfam graphical view of domain structure.

SMART

SM00301; DM; 1.
SMART graphical view of domain structure.

PROSITE

PS40000; DM_1; 1.
PS50809; DM_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9Y5R5; -.

Genome annotation databases

Ensembl

ENSG00000173253; Homo sapiens. [Contig view]

GeneID

10655; -.

KEGG

hsa:10655; -.

Phylogenomic databases

HOVERGEN

Q9Y5R5; -.

Other

40507; -.

DMRT2; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

DNA-binding; Metal-binding; Nucleus; Transcription; Transcription regulation; Zinc.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 226`	`226`	`Doublesex- and mab-3-related transcription factor 2.`	`PRO_0000207048`
`DNA_BIND`	`119 165`	`47`	`DM.`

Sequence information

Length: 226 AA [This is the length of the unprocessed precursor]

Molecular weight: 24469 Da [This is the MW of the unprocessed precursor]

CRC64: D6DE6CB7EF5EDD43 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MADPQAGSAA GDWEIDVESL ELEEDVCGAP RSTPPGPSPP PADGDCEDDE DDDGVDEDAE 

        70         80         90        100        110        120 
EEGDGEEAGA SPGMPGQPEQ RGGPQPRPPL APQASPAGTG PRERCTPAGG GAEPRKLSRT 

       130        140        150        160        170        180 
PKCARCRNHG VVSCLKGHKR FCRWRDCQCA NCLLVVERQR VMAAQVALRR QQATEDKKGL 

       190        200        210        220 
SGKQNNFERK AVYQRQVRAP SLLAKSILEV LLGLFYSYYV YIMNHL

Q9Y5R5 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools