|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
Tanaka S.;
"Cyclophilin homologue overexpressed in liver cancer.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
|
[2]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G.,
Barlow K.F.,
McLay K.E.,
Kaul R.,
Swarbreck D.,
Dunham A.,
Scott C.E.,
Howe K.L.,
Woodfine K.,
Spencer C.C.A.,
Jones M.C.,
Gillson C.,
Searle S.,
Zhou Y.,
Kokocinski F.,
McDonald L.,
Evans R.,
Phillips K.,
Atkinson A., ![]()
Cooper R.,
Jones C.,
Hall R.E.,
Andrews T.D.,
Lloyd C.,
Ainscough R.,
Almeida J.P.,
Ambrose K.D.,
Anderson F.,
Andrew R.W.,
Ashwell R.I.S.,
Aubin K.,
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Beasley H.,
Bethel G.,
Bird C.P.,
Bray-Allen S.,
Brown J.Y.,
Brown A.J.,
Buckley D.,
Burton J.,
Bye J.,
Carder C.,
Chapman J.C.,
Clark S.Y.,
Clarke G.,
Clee C.,
Cobley V.,
Collier R.E.,
Corby N.,
Coville G.J.,
Davies J.,
Deadman R.,
Dunn M.,
Earthrowl M.,
Ellington A.G.,
Errington H.,
Frankish A.,
Frankland J.,
French L.,
Garner P.,
Garnett J.,
Gay L.,
Ghori M.R.J.,
Gibson R.,
Gilby L.M.,
Gillett W.,
Glithero R.J.,
Grafham D.V.,
Griffiths C.,
Griffiths-Jones S.,
Grocock R.,
Hammond S.,
Harrison E.S.I.,
Hart E.,
Haugen E.,
Heath P.D.,
Holmes S.,
Holt K.,
Howden P.J.,
Hunt A.R.,
Hunt S.E.,
Hunter G.,
Isherwood J.,
James R.,
Johnson C.,
Johnson D.,
Joy A.,
Kay M.,
Kershaw J.K.,
Kibukawa M.,
Kimberley A.M.,
King A.,
Knights A.J.,
Lad H.,
Laird G.,
Lawlor S.,
Leongamornlert D.A.,
Lloyd D.M.,
Loveland J.,
Lovell J.,
Lush M.J.,
Lyne R.,
Martin S.,
Mashreghi-Mohammadi M.,
Matthews L.,
Matthews N.S.W.,
McLaren S.,
Milne S.,
Mistry S.,
Moore M.J.F.,
Nickerson T.,
O'Dell C.N.,
Oliver K.,
Palmeiri A.,
Palmer S.A.,
Parker A.,
Patel D.,
Pearce A.V.,
Peck A.I.,
Pelan S.,
Phelps K.,
Phillimore B.J.,
Plumb R.,
Rajan J.,
Raymond C.,
Rouse G.,
Saenphimmachak C.,
Sehra H.K.,
Sheridan E.,
Shownkeen R.,
Sims S.,
Skuce C.D.,
Smith M.,
Steward C.,
Subramanian S.,
Sycamore N.,
Tracey A.,
Tromans A.,
Van Helmond Z.,
Wall M.,
Wallis J.M.,
White S.,
Whitehead S.L.,
Wilkinson J.E.,
Willey D.L.,
Williams H.,
Wilming L.,
Wray P.W.,
Wu Z.,
Coulson A.,
Vaudin M.,
Sulston J.E.,
Durbin R.M.,
Hubbard T.,
Wooster R.,
Dunham I.,
Carter N.P.,
McVean G.,
Ross M.T.,
Harrow J.,
Olson M.V.,
Beck S.,
Rogers J.,
Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
|
[3]
|
TISSUE SPECIFICITY.
DOI=10.1038/sj.onc.1205339; PubMed=11948409 [NCBI, ExPASy, EBI, Israel, Japan]
Meza-Zepeda L.A.,
Forus A.,
Lygren B.,
Dahlberg A.B.,
Godager L.H.,
South A.P.,
Marenholz I.,
Lioumi M.,
Florenes V.A.,
Maelandsmo G.M.,
Serra M.,
Mischke D.,
Nizetic D.,
Ragoussis J.,
Tarkkanen M.,
Nesland J.M.,
Knuutila S.,
Myklebost O.;
"Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21.";
Oncogene 21:2261-2269(2002).
|
|
|
|
- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
- TISSUE SPECIFICITY: Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.
- MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.
- SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
- SIMILARITY: Contains 1 PPIase cyclophilin-type domain.
- CAUTION: Expression studies do not distinguish between PPIAL4B and PPIAL4 (PubMed:11948409).
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 164 AA [This is the length of the unprocessed precursor] |
Molecular weight: 18182 Da [This is the MW of the unprocessed precursor] |
CRC64: 99D50A72B0896C4C [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MVNSVVFFDI TVDGKPLGRI SIKLFADKIL KTAENFRALS TGEKGFRYKG SCFHRIIPGF
70 80 90 100 110 120
MCQGGDFTRH NGTGDKSIYG EKFDDENLIR KHTGSGILSM ANAGPNTNGS QFFICAAKTE
130 140 150 160
WLDGKHVAFG KVKERVNIVE AMEHFGYRNS KTSKKITIAD CGQF
|
Q9Y536 in FASTA format |
|
ExPASy Home page
SIB Switzerland
