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UniProtKB/Swiss-Prot entry Q5T1M5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FKB15_HUMAN
Primary accession number Q5T1M5
Secondary accession numbers Q05DK8 Q5T1M2 Q6DD85 Q9Y4D0
Integrated into Swiss-Prot on September 11, 2007
Sequence was last modified on September 11, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 36)
Name and origin of the protein
Protein name FK506-binding protein 15
Synonyms None
Gene name
Name: FKBP15
Synonyms: KIAA0674
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-413.
TISSUE=Brain;
DOI=10.1093/dnares/5.3.169; PubMed=9734811 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.";
DNA Res. 5:169-176(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02465; PubMed=15164053 [NCBI, ExPASy, EBI, Israel, Japan]
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 548-1219 (ISOFORM 2), AND VARIANT GLN-413.
TISSUE=Eye, and Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1114 AND SER-1164, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-956, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161; SER-1162 AND SER-1164, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161; SER-1162 AND SER-1164, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1002/pmic.200700884; PubMed=18318008 [NCBI, ExPASy, EBI, Israel, Japan]
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.;
"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.";
Proteomics 8:1346-1361(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB014574; BAA31649.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL449305; CAI10963.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL449305; CAI10964.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL449105; CAI10964.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL449105; CAI95402.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL449305; CAI95402.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009609; AAH09609.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC077732; AAH77732.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T00363; T00363.
RefSeq NP_056073.1; -.
UniGene Hs.522351
3D structure databases
ModBase Q5T1M5.
PTM databases
PhosphoSite Q5T1M5; -.
Organism-specific databases
HGNC HGNC:23397; FKBP15.
GenAtlas FKBP15.
HPA HPA007979; -.
GeneCards Q5T1M5.
HUGE KIAA0674.
Gene expression databases
CleanEx HS_FKBP15; -.
Family and domain databases
InterPro IPR001179; PPIase_FKBP.
Graphical view of domain structure.
Pfam PF00254; FKBP_C; 1.
Pfam graphical view of domain structure.
PROSITE PS50059; FKBP_PPIASE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q5T1M5.
Genome annotation databases
Ensembl ENSG00000119321; Homo sapiens. [Contig view]
GeneID 23307; -.
KEGG hsa:23307; -.
Phylogenomic databases
HOGENOM Q5T1M5; -.
HOVERGEN Q5T1M5; -.
Other
ProtoNet Q5T1M5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell projection; Coiled coil; Cytoplasm; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1219  1219     FK506-binding protein 15. PRO_0000299556
DOMAIN   197    290  94     PPIase FKBP-type. 
REGION   72    169  98     Important for function in growth cone organization (By similarity). 
COILED   522    789  268     Potential. 
COILED   818    878  61     Potential. 
COILED   925    951  27     Potential. 
COMPBIAS   1208   1216  9     Poly-Asp. 
MOD_RES   311    311        Phosphoserine. 
MOD_RES   956    956        Phosphoserine. 
MOD_RES   1097   1097        Phosphoserine (By similarity). 
MOD_RES   1099   1099        Phosphothreonine (By similarity). 
MOD_RES   1114   1114        Phosphoserine. 
MOD_RES   1161   1161        Phosphoserine. 
MOD_RES   1162   1162        Phosphoserine. 
MOD_RES   1164   1164        Phosphoserine. 
MOD_RES   1195   1195        Phosphoserine (By similarity). 
VAR_SEQ   462    472        PYAGMQAYAYP -> VTFYNRINYIL (in isoform 3). VSP_027756
VAR_SEQ   473   1219        Missing (in isoform 3). VSP_027757
VAR_SEQ   629    638        Missing (in isoform 2). VSP_027758
VARIANT   106    106  1     A -> T (in dbSNP:rs1133618 [NCBI]). VAR_034851 
VARIANT   413    413  1     H -> Q (in dbSNP:rs10435864 [NCBI]). VAR_034852 
VARIANT   434    434  1     L -> F (in dbSNP:rs10465129 [NCBI]). VAR_034853 
Sequence information
Length: 1219 AA [This is the length of the unprocessed precursor] Molecular weight: 133630 Da [This is the MW of the unprocessed precursor] CRC64: 86563D82B540B51D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFGAGDEDDT DFLSPSGGAR LASLFGLDQA AAGHGNEFFQ YTAPKQPKKG QGTAATGNQA 

        70         80         90        100        110        120 
TPKTAPATMS TPTILVATAV HAYRYTNGQY VKQGKFGAAV LGNHTAREYR ILLYISQQQP 

       130        140        150        160        170        180 
VTVARIHVNF ELMVRPNNYS TFYDDQRQNW SIMFESEKAA VEFNKQVCIA KCNSTSSLDA 

       190        200        210        220        230        240 
VLSQDLIVAD GPAVEVGDSL EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKG 

       250        260        270        280        290        300 
WEDGMLGMKK GGKRLLIVPP ACAVGSEGVI GWTQATDSIL VFEVEVRRVK FARDSGSDGH 

       310        320        330        340        350        360 
SVSSRDSAAP SPIPGADNLS ADPVVSPPTS IPFKSGEPAL RTKSNSLSEQ LAINTSPDAV 

       370        380        390        400        410        420 
KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNTLQGGG QPVVTPSVQP SLHPAHPALP 

       430        440        450        460        470        480 
QMTSQAPQPS VTGLQAPSAA LMQVSSLDSH SAVSGNAQSF QPYAGMQAYA YPQASAVTSQ 

       490        500        510        520        530        540 
LQPVRPLYPA PLSQPPHFQG SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL 

       550        560        570        580        590        600 
QKHSAGNSML IPSMSVTMET SMIMSNIQRI IQENERLKQE ILEKSNRIEE QNDKISELIE 

       610        620        630        640        650        660 
RNQRYVEQSN LMMEKRNNSL QTATENTQAR VLHAEQEKAK VTEELAAATA QVSHLQLKMT 

       670        680        690        700        710        720 
AHQKKETELQ MQLTESLKET DLLRGQLTKV QAKLSELQET SEQAQSKFKS EKQNRKQLEL 

       730        740        750        760        770        780 
KVTSLEEELT DLRVEKESLE KNLSERKKKS AQERSQAEEE IDEIRKSYQE ELDKLRQLLK 

       790        800        810        820        830        840 
KTRVSTDQAA AEQLSLVQAE LQTQWEAKCE HLLASAKDEH LQQYQEVCAQ RDAYQQKLVQ 

       850        860        870        880        890        900 
LQEKCLALQA QITALTKQNE QHIKELEKNK SQMSGVEAAA SDPSEKVKKI MNQVFQSLRR 

       910        920        930        940        950        960 
EFELEESYNG RTILGTIMNT IKMVTLQLLN QQEQEKEESS SEEEEEKAEE RPRRPSQEQS 

       970        980        990       1000       1010       1020 
ASASSGQPQA PLNRERPESP MVPSEQVVEE AVPLPPQALT TSQDGHRRKG DSEAEALSEI 

      1030       1040       1050       1060       1070       1080 
KDGSLPPELS CIPSHRVLGP PTSIPPEPLG PVSMDSECEE SLAASPMAAK PDNPSGKVCV 

      1090       1100       1110       1120       1130       1140 
REVAPDGPLQ ESSTRLSLTS DPEEGDPLAL GPESPGEPQP PQLKKDDVTS STGPHKELSS 

      1150       1160       1170       1180       1190       1200 
TEAGSTVAGA ALRPSHHSQR SSLSGDEEDE LFKGATLKAL RPKAQPEEED EDEVSMKGRP 

      1210 
PPTPLFGDDD DDDDIDWLG 

Q5T1M5 in FASTA format

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