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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
DOI=10.1093/emboj/18.20.5789; PubMed=10523320 [NCBI, ExPASy, EBI, Israel, Japan]
Achsel T.,
Brahms H.,
Kastner B.,
Bachi A.,
Wilm M.,
Luehrmann R.;
"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.";
EMBO J. 18:5789-5802(1999).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
Olavesen M.G.,
Campbell R.D.;
"Characterisation of the novel gene G7b located in the class III region of the human major histocompatibility complex.";
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
Schmarda A.,
Fresser F.,
Paulmichl M.;
"Human SMX5 homolog.";
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.1736803; PubMed=14656967 [NCBI, ExPASy, EBI, Israel, Japan]
Xie T.,
Rowen L.,
Aguado B.,
Ahearn M.E.,
Madan A.,
Qin S.,
Campbell R.D.,
Hood L.;
"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.";
Genome Res. 13:2621-2636(2003).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Shiina S.,
Tamiya G.,
Oka A.,
Inoko H.;
"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Hypothalamus;
DOI=10.1073/pnas.160270997; PubMed=10931946 [NCBI, ExPASy, EBI, Israel, Japan]
Hu R.-M.,
Han Z.-G.,
Song H.-D.,
Peng Y.-D.,
Huang Q.-H.,
Ren S.-X.,
Gu Y.-J.,
Huang C.-H.,
Li Y.-B.,
Jiang C.-L.,
Fu G.,
Zhang Q.-H.,
Gu B.-W.,
Dai M.,
Mao Y.-F.,
Gao G.-F.,
Rong R.,
Ye M.,
Zhou J., ![]()
Xu S.-H.,
Gu J.,
Shi J.-X.,
Jin W.-R.,
Zhang C.-K.,
Wu T.-M.,
Huang G.-Y.,
Chen Z.,
Chen M.-D.,
Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
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[7]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[8]
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IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE SPICEOSOMAL C COMPLEX.
DOI=10.1017/S1355838202021088; PubMed=11991638 [NCBI, ExPASy, EBI, Israel, Japan]
Jurica M.S.,
Licklider L.J.,
Gygi S.P.,
Grigorieff N.,
Moore M.J.;
"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.";
RNA 8:426-439(2002).
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[9]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-35, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J.,
Moritz A.,
Lee K.A.,
Guo A.,
Goss V.L.,
Spek E.J.,
Zhang H.,
Zha X.-M.,
Polakiewicz R.D.,
Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
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[10]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-79, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S.,
Ballif B.A.,
Smogorzewska A.,
McDonald E.R. III,
Hurov K.E.,
Luo J.,
Bakalarski C.E.,
Zhao Z.,
Solimini N.,
Lerenthal Y.,
Shiloh Y.,
Gygi S.P.,
Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
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[11]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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- FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing.
- SUBUNIT: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. LSm subunits form a heteromer with a donut shape.
- INTERACTION:
P31689:DNAJA1; NbExp=2; IntAct=EBI-347416, EBI-347834;
Q01780:EXOSC10; NbExp=1; IntAct=EBI-347416, EBI-358236;
O15116:LSM1; NbExp=2; IntAct=EBI-347416, EBI-347619;
P62310:LSM3; NbExp=5; IntAct=EBI-347416, EBI-348239;
Q9UK45:LSM7; NbExp=3; IntAct=EBI-347416, EBI-348372;
O95777:LSM8; NbExp=3; IntAct=EBI-347416, EBI-347779;
P62316:SNRPD2; NbExp=2; IntAct=EBI-347416, EBI-297993;
P62304:SNRPE; NbExp=2; IntAct=EBI-347416, EBI-348082;
Q9H9D4:ZNF408; NbExp=3; IntAct=EBI-347416, EBI-347633;
- SUBCELLULAR LOCATION: Nucleus (Potential).
- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
- SIMILARITY: Belongs to the snRNP Sm proteins family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 95 AA [This is the length of the unprocessed precursor] |
Molecular weight: 10835 Da [This is the MW of the unprocessed precursor] |
CRC64: 623591A09A6ABACE [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK YPHMLSVKNC
70 80 90
FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ
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Q9Y333 in FASTA format |
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