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[1]
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NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT VAL-9.
PubMed=10100484 [NCBI, ExPASy, EBI, Israel, Japan]
Tekur S.,
Pawlak A.,
Guellaen G.,
Hecht N.B.;
"Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization.";
J. Androl. 20:135-144(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-9.
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[3]
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TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
DOI=10.1038/sj.bjc.6602987; PubMed=16479255 [NCBI, ExPASy, EBI, Israel, Japan]
Kohno Y.,
Matsuki Y.,
Tanimoto A.,
Izumi H.,
Uchiumi T.,
Kohno K.,
Shimajiri S.,
Sasaguri Y.;
"Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen.";
Br. J. Cancer 94:710-716(2006).
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- FUNCTION: Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity).
- SUBUNIT: Found in a mRNP complex with PABPC1 and CSDA (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
- TISSUE SPECIFICITY: Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level).
- PTM: Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by a kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind RNA in vitro (By similarity).
- SIMILARITY: Contains 1 CSD (cold-shock) domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 364 AA [This is the length of the unprocessed precursor] |
Molecular weight: 38518 Da [This is the MW of the unprocessed precursor] |
CRC64: 0B16DEF46F4634FA [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSEVEAAAGA TAVPAATVPA TAAGVVAVVV PVPAGEPQKG GGAGGGGGAA SGPAAGTPSA
70 80 90 100 110 120
PGSRTPGNPA TAVSGTPAPP ARSQADKPVL AIQVLGTVKW FNVRNGYGFI NRNDTKEDVF
130 140 150 160 170 180
VHQTAIKRNN PRKFLRSVGD GETVEFDVVE GEKGAEATNV TGPGGVPVKG SRYAPNRRKS
190 200 210 220 230 240
RRFIPRPPSV APPPMVAEIP SAGTGPGSKG ERAEDSGQRP RRWCPPPFFY RRRFVRGPRP
250 260 270 280 290 300
PNQQQPIEGT DRVEPKETAP LEGHQQQGDE RVPPPRFRPR YRRPFRPRPR QQPTTEGGDG
310 320 330 340 350 360
ETKPSQGPAD GSRPEPQRPR NRPYFQRRRQ QAPGPQQAPG PRQPAAPETS APVNSGDPTT
TILE
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Q9Y2T7 in FASTA format |
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ExPASy Home page
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