[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
TISSUE=Brain;
DOI=10.1093/dnares/6.1.63; PubMed=10231032 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T.,
Ishikawa K.,
Suyama M.,
Kikuno R.,
Hirosawa M.,
Miyajima N.,
Tanaka A.,
Kotani H.,
Nomura N.,
Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 6:63-70(1999).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C).
TISSUE=Lung;
PubMed=9892180 [NCBI, ExPASy, EBI, Israel, Japan]
Tran Y.K.,
Boegler O.,
Gorse K.M.,
Wieland I.,
Green M.R.,
Newsham I.F.;
"A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer.";
Cancer Res. 59:35-43(1999).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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INTERACTION WITH CADM1.
PubMed=12234973 [NCBI, ExPASy, EBI, Israel, Japan]
Yageta M.,
Kuramochi M.,
Masuda M.,
Fukami T.,
Fukuhara H.,
Maruyama T.,
Shibuya M.,
Murakami Y.;
"Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer.";
Cancer Res. 62:5129-5133(2002).
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[5]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-962, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Villen J.,
Gerber S.A.,
Rush J.,
Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
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[6]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-762, AND MASS SPECTROMETRY.
TISSUE=Platelet;
DOI=10.1021/pr0704130; PubMed=18088087 [NCBI, ExPASy, EBI, Israel, Japan]
Zahedi R.P.,
Lewandrowski U.,
Wiesner J.,
Wortelkamp S.,
Moebius J.,
Schuetz C.,
Walter U.,
Gambaryan S.,
Sickmann A.;
"Phosphoproteome of resting human platelets.";
J. Proteome Res. 7:526-534(2008).
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- FUNCTION: Critical growth regulator in the pathogenesis of meningiomas.
- SUBUNIT: Interacts with CADM1.
- INTERACTION:
Q9NRG4:SMYD2; NbExp=1; IntAct=EBI-310986, EBI-1055671;
P31946:YWHAB; NbExp=1; IntAct=EBI-310986, EBI-359815;
P61981:YWHAG; NbExp=1; IntAct=EBI-310986, EBI-359832;
P27348:YWHAQ; NbExp=1; IntAct=EBI-310986, EBI-359854;
P63104:YWHAZ; NbExp=1; IntAct=EBI-310986, EBI-347088;
- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
- ALTERNATIVE PRODUCTS:
3 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.
- TISSUE SPECIFICITY: Expressed at high levels in brain, with lower levels in kidney, intestine, and testis.
- SIMILARITY: Contains 1 FERM domain.
- SEQUENCE CAUTION:
- Sequence=AAC79806.1; Type=Frameshift; Positions=29, 59;
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