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UniProtKB/Swiss-Prot entry Q9Y2G8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DJC16_HUMAN
Primary accession number Q9Y2G8
Secondary accession numbers Q68D57 Q86X32 Q8N5P4
Integrated into Swiss-Prot on May 30, 2006
Sequence was last modified on May 30, 2006 (Sequence version 3)
Annotations were last modified on    May 5, 2009 (Entry version 55)
Name and origin of the protein
Protein name DnaJ homolog subfamily C member 16 [Precursor]
Synonyms None
Gene name
Name: DNAJC16
Synonyms: KIAA0962
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1093/dnares/6.1.63; PubMed=10231032 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 6:63-70(1999).
[2]
SEQUENCE REVISION.
DOI=10.1093/dnares/9.3.99; PubMed=12168954 [NCBI, ExPASy, EBI, Israel, Japan]
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.";
DNA Res. 9:99-106(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Retina;
DOI=10.1186/1471-2164-8-399; PubMed=17974005 [NCBI, ExPASy, EBI, Israel, Japan]
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Skin, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB023179; BAA76806.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR749259; CAH18115.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR749567; CAH18363.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL512883; CAI12976.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL121992; CAI12976.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL121992; CAI22371.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL512883; CAI22371.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC031991; AAH31991.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC047363; AAH47363.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00006433; -.
IPI00759581; -.
RefSeq NP_056106.1; -.
UniGene Hs.655410
3D structure databases
HSSP P08622; 1BQZ. [HSSP ENTRY / PDB]
SMR Q9Y2G8; 19-99.
ModBase Q9Y2G8.
Organism-specific databases
GeneCards GC01P015725; -.
HGNC HGNC:29157; DNAJC16.
GenAtlas DNAJC16.
PharmGKB PA142671964; -.
HUGE KIAA0962.
Gene expression databases
ArrayExpress Q9Y2G8; -.
Bgee Q9Y2G8; -.
CleanEx HS_DNAJC16; -.
GermOnline ENSG00000116138; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0051082; Molecular function: unfolded protein binding (inferred from electronic annotation from InterPro).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0006457; Biological process: protein folding (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
IPR003095; Hsp_DnaJ.
IPR017936; Thioredoxin-like.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
G3DSA:3.40.30.10; Thioredoxin_fold; 1.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
Pfam graphical view of domain structure.
PRINTS PR00625; DNAJPROTEIN.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; 1.
PS50076; DNAJ_2; 1.
PS51352; THIOREDOXIN_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9Y2G8; -.
Genome annotation databases
Ensembl ENSG00000116138; Homo sapiens. [Contig view]
GeneID 23341; -.
KEGG hsa:23341; -.
Phylogenomic databases
HOGENOM Q9Y2G8; -.
HOVERGEN Q9Y2G8; -.
OMA Q9Y2G8; KLTAFAY.
Other
NextBio 45297; -.
ProtoNet Q9Y2G8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Glycoprotein; Membrane; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    25  25     Potential. 
CHAIN   26   782  757     DnaJ homolog subfamily C member 16. PRO_0000236683
TOPO_DOM   26   535  510     Cytoplasmic (Potential). 
TRANSMEM   536   556  21     Anchor for type IV membrane protein (Potential). 
TOPO_DOM   557   782  226     Extracellular (Potential). 
DOMAIN   29    93  65     J. 
DOMAIN   119   247  129     Thioredoxin. 
COMPBIAS   102   107  6     Poly-Gln. 
COMPBIAS   718   721  4     Poly-Glu. 
CARBOHYD   631   631        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   1   312        Missing (in isoform 2). VSP_018583
Sequence information
Length: 782 AA [This is the length of the unprocessed precursor] Molecular weight: 90591 Da [This is the MW of the unprocessed precursor] CRC64: 42D564BBC6EED981 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEVRKLSISW QFLIVLVLIL QILSALDFDP YRVLGVSRTA SQADIKKAYK KLAREWHPDK 

        70         80         90        100        110        120 
NKDPGAEDKF IQISKAYEIL SNEEKRSNYD QYGDAGENQG YQKQQQQREY RFRHFHENFY 

       130        140        150        160        170        180 
FDESFFHFPF NSERRDSIDE KYLLHFSHYV NEVVPDSFKK PYLIKITSDW CFSCIHIEPV 

       190        200        210        220        230        240 
WKEVIQELEE LGVGIGVVHA GYERRLAHHL GAHSTPSILG IINGKISFFH NAVVRENLRQ 

       250        260        270        280        290        300 
FVESLLPGNL VEKVTNKNYV RFLSGWQQEN KPHVLLFDQT PIVPLLYKLT AFAYKDYLSF 

       310        320        330        340        350        360 
GYVYVGLRGT EEMTRRYNIN IYAPTLLVFK EHINRPADVI QARGMKKQII DDFITRNKYL 

       370        380        390        400        410        420 
LAARLTSQKL FHELCPVKRS HRQRKYCVVL LTAETTKLSK PFEAFLSFAL ANTQDTVRFV 

       430        440        450        460        470        480 
HVYSNRQQEF ADTLLPDSEA FQGKSAVSIL ERRNTAGRVV YKTLEDPWIG SESDKFILLG 

       490        500        510        520        530        540 
YLDQLRKDPA LLSSEAVLPD LTDELAPVFL LRWFYSASDY ISDCWDSIFH NNWREMMPLL 

       550        560        570        580        590        600 
SLIFSALFIL FGTVIVQAFS DSNDERESSP PEKEEAQEKT GKTEPSFTKE NSSKIPKKGF 

       610        620        630        640        650        660 
VEVTELTDVT YTSNLVRLRP GHMNVVLILS NSTKTSLLQK FALEVYTFTG SSCLHFSFLS 

       670        680        690        700        710        720 
LDKHREWLEY LLEFAQDAAP IPNQYDKHFM ERDYTGYVLA LNGHKKYFCL FKPQKTVEEE 

       730        740        750        760        770        780 
EAIGSCSDVD SSLYLGESRG KPSCGLGSRP IKGKLSKLSL WMERLLEGSL QRFYIPSWPE 


LD 

Q9Y2G8 in FASTA format

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