NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1016/S0378-1119(99)00098-0; PubMed=10231569 [NCBI, ExPASy, EBI, Israel, Japan]
Takeuchi O., Kawai T., Sanjo H., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeda K., Akira S.;
"TLR6: a novel member of an expanding Toll-like receptor family.";
Gene 231:59-65(1999).

[2]

FUNCTION.
PubMed=11441107 [NCBI, ExPASy, EBI, Israel, Japan]
Bulut Y., Faure E., Thomas L., Equils O., Arditi M.;
"Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.";
J. Immunol. 167:987-994(2001).

Comments

FUNCTION: Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.
SUBUNIT: Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
SIMILARITY: Belongs to the Toll-like receptor family.
SIMILARITY: Contains 13 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 TIR domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB020807; BAA78631.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00294125; -.

NP_006059.2; -.

3D structure databases

HSSP

Q15399; 1FYV. [HSSP ENTRY / PDB]

Q9Y2C9; 630-786.

PTM databases

Q9Y2C9; -.

Enzyme and pathway databases

Reactome

REACT_6900; Signaling in Immune system.

Organism-specific databases

GC04M038504; -.

HIX0031342; -.

HGNC:16711; TLR6.

605403; gene. [NCBI / EBI]

PharmGKB

PA38183; -.

Gene expression databases

Q9Y2C9; -.

Q9Y2C9; -.

HS_TLR6; -.

ENSG00000174130; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0030670;	Cellular component: phagocytic vesicle membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008034;	Molecular function: lipoprotein binding (inferred from sequence or structural similarity from UniProtKB).
GO:0004888;	Molecular function: transmembrane receptor activity (inferred from electronic annotation from InterPro).
GO:0007250;	Biological process: activation of NF-kappaB-inducing kinase activity (non-traceable author statement from UniProtKB).
GO:0042742;	Biological process: defense response to bacterium (traceable author statement from ProtInc).
GO:0006954;	Biological process: inflammatory response (inferred from electronic annotation from UniProtKB-KW).
GO:0045087;	Biological process: innate immune response (inferred from electronic annotation from UniProtKB-KW).
GO:0043123;	Biological process: positive regulation of I-kappaB kinase/NF-kappaB cascade (inferred from direct assay from MGI).
GO:0045410;	Biological process: positive regulation of interleukin-6 biosynthetic process (inferred from sequence or structural similarity from UniProtKB).
GO:0043507;	Biological process: positive regulation of JUN kinase activity (inferred from direct assay from MGI).
GO:0042088;	Biological process: T-helper 1 type immune response (inferred by curator from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR004075; IL1_rcpt_1.
IPR001611; Leu-rich_rpt.
IPR000483; LRR_C.
IPR000157; Toll-Interleukin_rcpt.
IPR017241; Toll-like_receptor.
Graphical view of domain structure.

Pfam

PF00560; LRR_1; 2.
PF01463; LRRCT; 1.
PF01582; TIR; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF037595; Toll-like_receptor; 1.

PRINTS

PR01537; INTRLKN1R1F.

SMART

SM00082; LRRCT; 1.
SM00255; TIR; 1.
SMART graphical view of domain structure.

PROSITE

PS50104; TIR; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9Y2C9; -.

Genome annotation databases

Ensembl

ENSG00000174130; Homo sapiens. [Contig view]

GeneID

10333; -.

KEGG

hsa:10333; -.

Phylogenomic databases

HOGENOM

Q9Y2C9; -.

HOVERGEN

Q9Y2C9; -.

Other

39189; -.

TLR6; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Cytoplasmic vesicle; Glycoprotein; Immune response; Inflammatory response; Innate immunity; Leucine-rich repeat; Membrane; Polymorphism; Receptor; Repeat; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 31`	`31`	`Potential.`
`CHAIN`	`32 796`	`765`	`Toll-like receptor 6.`	`PRO_0000034731`
`TOPO_DOM`	`32 586`	`555`	`Extracellular (Potential).`
`TRANSMEM`	`587 607`	`21`	`Potential.`
`TOPO_DOM`	`608 796`	`189`	`Cytoplasmic (Potential).`
`REPEAT`	`51 74`	`24`	`LRR 1.`
`REPEAT`	`75 98`	`24`	`LRR 2.`
`REPEAT`	`100 120`	`21`	`LRR 3.`
`REPEAT`	`121 144`	`24`	`LRR 4.`
`REPEAT`	`158 175`	`18`	`LRR 5.`
`REPEAT`	`176 201`	`26`	`LRR 6.`
`REPEAT`	`222 248`	`27`	`LRR 7.`
`REPEAT`	`376 400`	`25`	`LRR 8.`
`REPEAT`	`402 428`	`27`	`LRR 9.`
`REPEAT`	`430 447`	`18`	`LRR 10.`
`REPEAT`	`449 472`	`24`	`LRR 11.`
`REPEAT`	`474 496`	`23`	`LRR 12.`
`REPEAT`	`498 517`	`20`	`LRR 13.`
`DOMAIN`	`640 784`	`145`	`TIR.`
`CARBOHYD`	`144 144`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`186 186`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`214 214`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`253 253`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`285 285`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`359 359`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`423 423`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`434 434`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`583 583`		`N-linked (GlcNAc...) (Potential).`
`VARIANT`	`120 120`	`1`	`I -> T (in dbSNP:rs5743808 [NCBI]).`	`VAR_057289`
`VARIANT`	`194 194`	`1`	`L -> P (in dbSNP:rs5743809 [NCBI]).`	`VAR_057290`
`VARIANT`	`247 247`	`1`	`R -> K (in dbSNP:rs35220466 [NCBI]).`	`VAR_057291`
`VARIANT`	`327 327`	`1`	`V -> M (in dbSNP:rs3796508 [NCBI]).`	`VAR_057292`
`VARIANT`	`345 345`	`1`	`H -> Y (in dbSNP:rs5743813 [NCBI]).`	`VAR_057293`
`VARIANT`	`427 427`	`1`	`V -> A (in dbSNP:rs5743815 [NCBI]).`	`VAR_057294`
`VARIANT`	`465 465`	`1`	`V -> I (in dbSNP:rs5743816 [NCBI]).`	`VAR_057295`
`VARIANT`	`474 474`	`1`	`A -> T (in dbSNP:rs35762983 [NCBI]).`	`VAR_057296`
`VARIANT`	`783 783`	`1`	`M -> V (in dbSNP:rs5743822 [NCBI]).`	`VAR_057297`

Sequence information

Length: 796 AA [This is the length of the unprocessed precursor]

Molecular weight: 91890 Da [This is the MW of the unprocessed precursor]

CRC64: 35CEAEC05BFBA8BD [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTKDKEPIVK SFHFVCLMII IVGTRIQFSD GNEFAVDKSK RGLIHVPKDL PLKTKVLDMS 

        70         80         90        100        110        120 
QNYIAELQVS DMSFLSELTV LRLSHNRIQL LDLSVFKFNQ DLEYLDLSHN QLQKISCHPI 

       130        140        150        160        170        180 
VSFRHLDLSF NDFKALPICK EFGNLSQLNF LGLSAMKLQK LDLLPIAHLH LSYILLDLRN 

       190        200        210        220        230        240 
YYIKENETES LQILNAKTLH LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK 

       250        260        270        280        290        300 
FLSELTRGPT LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS 

       310        320        330        340        350        360 
KTTLKALTIE HITNQVFLFS QTALYTVFSE MNIMMLTISD TPFIHMLCPH APSTFKFLNF 

       370        380        390        400        410        420 
TQNVFTDSIF EKCSTLVKLE TLILQKNGLK DLFKVGLMTK DMPSLEILDV SWNSLESGRH 

       430        440        450        460        470        480 
KENCTWVESI VVLNLSSNML TDSVFRCLPP RIKVLDLHSN KIKSVPKQVV KLEALQELNV 

       490        500        510        520        530        540 
AFNSLTDLPG CGSFSSLSVL IIDHNSVSHP SADFFQSCQK MRSIKAGDNP FQCTCELREF 

       550        560        570        580        590        600 
VKNIDQVSSE VLEGWPDSYK CDYPESYRGS PLKDFHMSEL SCNITLLIVT IGATMLVLAV 

       610        620        630        640        650        660 
TVTSLCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRNL QFHAFISYSE HDSAWVKSEL 

       670        680        690        700        710        720 
VPYLEKEDIQ ICLHERNFVP GKSIVENIIN CIEKSYKSIF VLSPNFVQSE WCHYELYFAH 

       730        740        750        760        770        780 
HNLFHEGSNN LILILLEPIP QNSIPNKYHK LKALMTQRTY LQWPKEKSKR GLFWANIRAA 

       790 
FNMKLTLVTE NNDVKS

Q9Y2C9 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools