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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7), VARIANTS ESOPHAGEAL CANCER PRO-29 AND GLU-119, FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1073/pnas.96.7.3928; PubMed=10097140 [NCBI, ExPASy, EBI, Israel, Japan]
Ishii H.,
Baffa R.,
Numata S.,
Murakumo Y.,
Rattan S.,
Inoue H.,
Mori M.,
Fidanza V.,
Alder H.,
Croce C.M.;
"The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.";
Proc. Natl. Acad. Sci. U.S.A. 96:3928-3933(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Fetal brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[3]
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FUNCTION, AND ALTERNATIVE SPLICING.
DOI=10.1038/sj.onc.1204539; PubMed=11464283 [NCBI, ExPASy, EBI, Israel, Japan]
Cabeza-Arvelaiz Y.,
Sepulveda J.L.,
Lebovitz R.M.,
Thompson T.C.,
Chinault A.C.;
"Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22.";
Oncogene 20:4169-4179(2001).
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[4]
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FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, AND INTERACTION WITH EEF1G AND CDC2.
DOI=10.1073/pnas.181222898; PubMed=11504921 [NCBI, ExPASy, EBI, Israel, Japan]
Ishii H.,
Vecchione A.,
Murakumo Y.,
Baldassarre G.,
Numata S.,
Trapasso F.,
Alder H.,
Baffa R.,
Croce C.M.;
"FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.";
Proc. Natl. Acad. Sci. U.S.A. 98:10374-10379(2001).
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- FUNCTION: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor.
- SUBUNIT: Binds EEF1G and CDC2.
- INTERACTION:
P30307:CDC25C; NbExp=1; IntAct=EBI-1216080, EBI-974439;
- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity).
- ALTERNATIVE PRODUCTS:
7 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | Q9Y250-2 |
| Features which should be applied to build the isoform sequence: VSP_009946. |
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| Name | 3 |
| Isoform ID | Q9Y250-3 |
| Features which should be applied to build the isoform sequence: VSP_009945. |
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| Name | 4 |
| Isoform ID | Q9Y250-4 |
| Features which should be applied to build the isoform sequence: VSP_009944. |
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| Name | 5 |
| Isoform ID | Q9Y250-5 |
| Features which should be applied to build the isoform sequence: VSP_009943. |
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| Name | 6 |
| Isoform ID | Q9Y250-6 |
| Features which should be applied to build the isoform sequence: VSP_009942. |
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- TISSUE SPECIFICITY: Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.
- PTM: Phorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.
- DISEASE: Defects in LZTS1 are found in many types of tumors.
- SIMILARITY: Belongs to the LZTS family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 596 AA [This is the length of the unprocessed precursor] |
Molecular weight: 66613 Da [This is the MW of the unprocessed precursor] |
CRC64: 8ED96C707BA27659 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG
70 80 90 100 110 120
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG
130 140 150 160 170 180
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
190 200 210 220 230 240
SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG
250 260 270 280 290 300
HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
310 320 330 340 350 360
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE
370 380 390 400 410 420
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK
430 440 450 460 470 480
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA
490 500 510 520 530 540
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI
550 560 570 580 590
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI
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Q9Y250 in FASTA format |
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