[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), AND VARIANT LYS-501. PubMed=9315665 [NCBI, ExPASy, EBI, Israel, Japan] Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J.; "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor."; Mol. Cell. Biol. 17:6057-6067(1997).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), AND VARIANT LYS-501. TISSUE=Fetal brain; PubMed=10079256 [NCBI, ExPASy, EBI, Israel, Japan] Gray G.E., Mann R.S., Mitsiadis E., Henrique D., Carcangiu M.-L., Banks A., Leiman J., Ward D., Ish-Horowitz D., Artavanis-Tsakonas S.; "Human ligands of the Notch receptor."; Am. J. Pathol. 154:785-794(1999).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LONG AND SHORT), AND VARIANT LYS-501. TISSUE=Bone marrow; DOI=10.1006/geno.1999.6045; PubMed=10662552 [NCBI, ExPASy, EBI, Israel, Japan] Deng Y., Madan A., Banta A.B., Friedman C., Trask B.J., Hood L., Li L.; "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene."; Genomics 63:133-138(2000).
[4]	NUCLEOTIDE SEQUENCE [MRNA] OF 17-1238 (ISOFORM LONG). TISSUE=Heart; DOI=10.1016/S0925-4773(97)00146-9; PubMed=9486542 [NCBI, ExPASy, EBI, Israel, Japan] Valsecchi C., Ghezzi C., Ballabio A., Rugarli E.I.; "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions."; Mech. Dev. 69:203-207(1997).

Comments

FUNCTION: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
INTERACTION:
Q5VTD9:GFI1B; NbExp=1; IntAct=EBI-946223, EBI-946212;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	Long
Isoform ID	Q9Y219-1
This is the isoform sequence displayed in this entry.

Name	Short
Synonyms	HJAG2.del-E6
Isoform ID	Q9Y219-2
Features which should be applied to build the isoform sequence: VSP_001395.

TISSUE SPECIFICITY: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.
DISEASE: May be associated with Usher syndrome type IA (USHA1A) which describes a congenital sensory deafness associated with retinitis pigmentosa and feeble-mindedness.
SIMILARITY: Contains 1 DSL domain.
SIMILARITY: Contains 16 EGF-like domains.
SIMILARITY: Contains 1 VWFC domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/JAG2ID41030ch14q32.html";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF020201; AAB71189.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF003521; AAB61285.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF029778; AAB84215.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF029779; AAB84216.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF111170; AAD15562.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14330; CAA74706.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00032416; -.
IPI00221383; -.

RefSeq

NP_002217.3; -.
NP_660142.1; -.

UniGene

Hs.433445

3D structure databases

HSSP

P01132; 1GK5. [HSSP ENTRY / PDB]

ModBase

Q9Y219.

Protein-protein interaction databases

IntAct

Q9Y219; 2.

Enzyme and pathway databases

Reactome

REACT_299; Signaling by Notch.

Organism-specific databases

GC14M104679; -.

HIX0037647; -.

HGNC:6189; JAG2.

602570; gene. [NCBI / EBI]

PharmGKB

PA29987; -.

Gene expression databases

Q9Y219; -.

Q9Y219; -.

HS_JAG2; -.

ENSG00000184916; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (inferred from sequence or structural similarity from UniProtKB).
GO:0005509;	Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008083;	Molecular function: growth factor activity (inferred from direct assay from UniProtKB).
GO:0005112;	Molecular function: Notch binding (inferred from physical interaction from UniProtKB).
GO:0009912;	Biological process: auditory receptor cell fate commitment (inferred from sequence or structural similarity from UniProtKB).
GO:0007049;	Biological process: cell cycle (non-traceable author statement from UniProtKB).
GO:0001709;	Biological process: cell fate determination (non-traceable author statement from UniProtKB).
GO:0007219;	Biological process: Notch signaling pathway (non-traceable author statement from UniProtKB).
GO:0030334;	Biological process: regulation of cell migration (non-traceable author statement from UniProtKB).
GO:0042127;	Biological process: regulation of cell proliferation (inferred from direct assay from UniProtKB).
GO:0007283;	Biological process: spermatogenesis (inferred from expression pattern from UniProtKB).
GO:0045061;	Biological process: thymic T cell selection (inferred from direct assay from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR001774; DSL.
IPR006209; EGF.
IPR006210; EGF-like.
IPR013032; EGF-like_reg_CS.
IPR000152; EGF-type_Asp/Asn_hydroxyl_CS.
IPR001438; EGF_2.
IPR000742; EGF_3.
IPR001881; EGF_Ca_bd.
IPR013091; EGF_Ca_bd_2.
IPR018097; EGF_Ca_bd_CS.
IPR011651; Notch_ligand_N.
IPR001007; VWF_C.
Graphical view of domain structure.

Pfam

PF01414; DSL; 1.
PF00008; EGF; 12.
PF07645; EGF_CA; 1.
PF07657; MNNL; 1.
Pfam graphical view of domain structure.

PRINTS

PR00010; EGFBLOOD.

SMART

SM00051; DSL; 1.
SM00181; EGF; 6.
SM00179; EGF_CA; 9.
SM00214; VWC; 1.
SMART graphical view of domain structure.

PROSITE

PS00010; ASX_HYDROXYL; 10.
PS51051; DSL; 1.
PS00022; EGF_1; 16.
PS01186; EGF_2; 12.
PS50026; EGF_3; 15.
PS01187; EGF_CA; 8.
PS01208; VWFC_1; FALSE_NEG.
PS50184; VWFC_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q9Y219; -.

Genome annotation databases

Ensembl

ENSG00000184916; Homo sapiens. [Contig view]

GeneID

3714; -.

KEGG

hsa:3714; -.

Phylogenomic databases

HOGENOM

Q9Y219; -.

HOVERGEN

Q9Y219; -.

OMA

Q9Y219; QHGGTCK.

Other

14557; -.

Q9Y219; -.

JAG2; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Calcium; Developmental protein; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway; Polymorphism; Repeat; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`	`Potential.`
`CHAIN`	`24 1238`	`1215`	`Protein jagged-2.`	`PRO_0000007629`
`TOPO_DOM`	`27 1080`	`1054`	`Extracellular (Potential).`
`TRANSMEM`	`1081 1101`	`21`	`Potential.`
`TOPO_DOM`	`1102 1238`	`137`	`Cytoplasmic (Potential).`
`DOMAIN`	`196 240`	`45`	`DSL.`
`DOMAIN`	`241 274`	`34`	`EGF-like 1.`
`DOMAIN`	`275 305`	`31`	`EGF-like 2.`
`DOMAIN`	`307 345`	`39`	`EGF-like 3.`
`DOMAIN`	`347 383`	`37`	`EGF-like 4.`
`DOMAIN`	`385 421`	`37`	`EGF-like 5; calcium-binding (Potential).`
`DOMAIN`	`423 459`	`37`	`EGF-like 6; calcium-binding (Potential).`
`DOMAIN`	`461 496`	`36`	`EGF-like 7; calcium-binding (Potential).`
`DOMAIN`	`498 534`	`37`	`EGF-like 8.`
`DOMAIN`	`536 572`	`37`	`EGF-like 9.`
`DOMAIN`	`574 634`	`61`	`EGF-like 10; atypical.`
`DOMAIN`	`636 672`	`37`	`EGF-like 11; calcium-binding (Potential).`
`DOMAIN`	`674 710`	`37`	`EGF-like 12; calcium-binding (Potential).`
`DOMAIN`	`712 748`	`37`	`EGF-like 13.`
`DOMAIN`	`751 787`	`37`	`EGF-like 14.`
`DOMAIN`	`789 825`	`37`	`EGF-like 15; calcium-binding (Potential).`
`DOMAIN`	`827 863`	`37`	`EGF-like 16; calcium-binding (Potential).`
`DOMAIN`	`870 944`	`75`	`VWFC.`
`CARBOHYD`	`153 153`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`570 570`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`619 619`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`752 752`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`1058 1058`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`245 256`		`By similarity.`
`DISULFID`	`249 262`		`By similarity.`
`DISULFID`	`264 273`		`By similarity.`
`DISULFID`	`276 287`		`By similarity.`
`DISULFID`	`282 293`		`By similarity.`
`DISULFID`	`295 304`		`By similarity.`
`DISULFID`	`311 323`		`By similarity.`
`DISULFID`	`317 333`		`By similarity.`
`DISULFID`	`335 344`		`By similarity.`
`DISULFID`	`351 362`		`By similarity.`
`DISULFID`	`356 371`		`By similarity.`
`DISULFID`	`373 382`		`By similarity.`
`DISULFID`	`389 400`		`By similarity.`
`DISULFID`	`394 409`		`By similarity.`
`DISULFID`	`411 420`		`By similarity.`
`DISULFID`	`427 438`		`By similarity.`
`DISULFID`	`432 447`		`By similarity.`
`DISULFID`	`449 458`		`By similarity.`
`DISULFID`	`465 475`		`By similarity.`
`DISULFID`	`469 484`		`By similarity.`
`DISULFID`	`486 495`		`By similarity.`
`DISULFID`	`502 513`		`By similarity.`
`DISULFID`	`507 522`		`By similarity.`
`DISULFID`	`524 533`		`By similarity.`
`DISULFID`	`540 551`		`By similarity.`
`DISULFID`	`545 560`		`By similarity.`
`DISULFID`	`562 571`		`By similarity.`
`DISULFID`	`589 612`		`Potential.`
`DISULFID`	`606 622`		`Potential.`
`DISULFID`	`624 633`		`By similarity.`
`DISULFID`	`640 651`		`By similarity.`
`DISULFID`	`645 660`		`By similarity.`
`DISULFID`	`662 671`		`By similarity.`
`DISULFID`	`678 689`		`By similarity.`
`DISULFID`	`683 698`		`By similarity.`
`DISULFID`	`700 709`		`By similarity.`
`DISULFID`	`716 727`		`By similarity.`
`DISULFID`	`721 736`		`By similarity.`
`DISULFID`	`738 747`		`By similarity.`
`DISULFID`	`755 766`		`By similarity.`
`DISULFID`	`760 775`		`By similarity.`
`DISULFID`	`777 786`		`By similarity.`
`DISULFID`	`793 804`		`By similarity.`
`DISULFID`	`798 813`		`By similarity.`
`DISULFID`	`815 824`		`By similarity.`
`DISULFID`	`831 842`		`By similarity.`
`DISULFID`	`836 851`		`By similarity.`
`DISULFID`	`853 862`		`By similarity.`
`VAR_SEQ`	`424 461`		`Missing (in isoform Short).`	`VSP_001395`
`VARIANT`	`501 501`	`1`	`E -> K (in dbSNP:rs1057744 [NCBI]).`	`VAR_028113`
`VARIANT`	`538 538`	`1`	`D -> N (in dbSNP:rs9972231 [NCBI]).`	`VAR_048986`
`CONFLICT`	`8 12`		`RLPRR -> AFPPA (in Ref. 1; AAB71189).`
`CONFLICT`	`119 119`		`A -> P (in Ref. 1; AAB71189).`
`CONFLICT`	`129 129`		`L -> F (in Ref. 1; AAB71189).`
`CONFLICT`	`384 384`		`L -> SA (in Ref. 4).`
`CONFLICT`	`424 426`		`ANE -> VND (in Ref. 1; AAB71189).`
`CONFLICT`	`1235 1235`		`A -> V (in Ref. 2; AAB61285).`

Sequence information

Length: 1238 AA [This is the length of the unprocessed precursor]

Molecular weight: 133367 Da [This is the MW of the unprocessed precursor]

CRC64: 23B4FCD7D2891EF7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRAQGRGRLP RRLLLLLALW VQAARPMGYF ELQLSALRNV NGELLSGACC DGDGRTTRAG 

        70         80         90        100        110        120 
GCGHDECDTY VRVCLKEYQA KVTPTGPCSY GHGATPVLGG NSFYLPPAGA AGDRARARAR 

       130        140        150        160        170        180 
AGGDQDPGLV VIPFQFAWPR SFTLIVEAWD WDNDTTPNEE LLIERVSHAG MINPEDRWKS 

       190        200        210        220        230        240 
LHFSGHVAHL ELQIRVRCDE NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC 

       250        260        270        280        290        300 
KEAVCKQGCN LLHGGCTVPG ECRCSYGWQG RFCDECVPYP GCVHGSCVEP WQCNCETNWG 

       310        320        330        340        350        360 
GLLCDKDLNY CGSHHPCTNG GTCINAEPDQ YRCTCPDGYS GRNCEKAEHA CTSNPCANGG 

       370        380        390        400        410        420 
SCHEVPSGFE CHCPSGWSGP TCALDIDECA SNPCAAGGTC VDQVDGFECI CPEQWVGATC 

       430        440        450        460        470        480 
QLDANECEGK PCLNAFSCKN LIGGYYCDCI PGWKGINCHI NVNDCRGQCQ HGGTCKDLVN 

       490        500        510        520        530        540 
GYQCVCPRGF GGRHCELERD ECASSPCHSG GLCEDLADGF HCHCPQGFSG PLCEVDVDLC 

       550        560        570        580        590        600 
EPSPCRNGAR CYNLEGDYYC ACPDDFGGKN CSVPREPCPG GACRVIDGCG SDAGPGMPGT 

       610        620        630        640        650        660 
AASGVCGPHG RCVSQPGGNF SCICDSGFTG TYCHENIDDC LGQPCRNGGT CIDEVDAFRC 

       670        680        690        700        710        720 
FCPSGWEGEL CDTNPNDCLP DPCHSRGRCY DLVNDFYCAC DDGWKGKTCH SREFQCDAYT 

       730        740        750        760        770        780 
CSNGGTCYDS GDTFRCACPP GWKGSTCAVA KNSSCLPNPC VNGGTCVGSG ASFSCICRDG 

       790        800        810        820        830        840 
WEGRTCTHNT NDCNPLPCYN GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA 

       850        860        870        880        890        900 
TCVDEINGYR CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD 

       910        920        930        940        950        960 
CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG AEEPPSTPCL 

       970        980        990       1000       1010       1020 
PRSGHLDNNC ARLTLHFNRD HVPQGTTVGA ICSGIRSLPA TRAVARDRLL VLLCDRASSG 

      1030       1040       1050       1060       1070       1080 
ASAVEVAVSF SPARDLPDSS LIQGAAHAIV AAITQRGNSS LLLAVTEVKV ETVVTGGSST 

      1090       1100       1110       1120       1130       1140 
GLLVPVLCGA FSVLWLACVV LCVWWTRKRR KERERSRLPR EESANNQWAP LNPIRNPIER 

      1150       1160       1170       1180       1190       1200 
PGGHKDVLYQ CKNFTPPPRR ADEALPGPAG HAAVREDEED EDLGRGEEDS LEAEKFLSHK 

      1210       1220       1230 
FTKDPGRSPG RPAHWASGPK VDNRAVRSIN EARYAGKE

Q9Y219 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools