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UniProtKB/Swiss-Prot entry Q9XT87

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_MONDO
Primary accession number Q9XT87
Secondary accession numbers None
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
LDH muscle subunit
LDH-M
Gene name
Name: LDHA
From
Monodelphis domestica (Short-tailed gray opossum) [TaxID: 13616] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Tsoi S.C.-M., Li J.Y., Mannen H., Li S.S.-L.;
"Molecular evolution of vertebrate lactate dehydrogenase isozymes by gene duplication.";
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF070996; AAD40733.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001028147.1; -.
XP_001364556.1; -.
UniGene Mdm.239
3D structure databases
HSSP P00338; 1I10. [HSSP ENTRY / PDB]
SMR Q9XT87; 2-332.
ModBase Q9XT87.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q9XT87.
Genome annotation databases
Ensembl ENSMODG00000006522; Monodelphis domestica. [Contig view]
ENSMODG00000019596; Monodelphis domestica. [Contig view]
GeneID 100012604; -.
503513; -.
KEGG mdo:100012604; -.
mdo:503513; -.
Phylogenomic databases
HOVERGEN Q9XT87; -.
Other
ProtoNet Q9XT87.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   332  331     L-lactate dehydrogenase A chain. PRO_0000168413
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   193   193        Proton acceptor (By similarity). 
BINDING   99    99        NAD (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   138   138        NAD or substrate (By similarity). 
BINDING   169   169        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
MOD_RES   239   239        Phosphotyrosine (By similarity). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 36358 Da [This is the MW of the unprocessed precursor] CRC64: C9D11DA82504AA9D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGTVKDQLIL NVLKEEQTPH NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG 

        70         80         90        100        110        120 
EMMDLQHGSL FLKTPKIVSS KDYAVTANSK LVVITAGARQ QEGESRLNLV QRNVNIFKFI 

       130        140        150        160        170        180 
IPNIVKYSPN CKLLVVSNPV DILTYVAWKL SGFPKNRVIG SGCNLDSARF RYLMGEKLGI 

       190        200        210        220        230        240 
HSSSCHGWIL GEHGDSSVPV WSGVNVAGVS LKSLHPALGT DSDSEQWKDV HKQVVESAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPISTMIKGL YGINEDVFLS VPCILGQNGI 

       310        320        330 
SDVVKVTLTT EEESRLKQSA DTLWGIQKEL QF
Q9XT87 in FASTA format

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