NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Kim J.W., Kang D.G., Rha E.G.;
"Cloning and sequencing of the gene for beta-hydroxybutyrate dehydrogenase from Ralstonia eutropha.";
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nbt1244; PubMed=16964242 [NCBI, ExPASy, EBI, Israel, Japan]
Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16.";
Nat. Biotechnol. 24:1257-1262(2006).

Comments

CATALYTIC ACTIVITY: (R)-3-hydroxybutanoate + NAD⁺ = acetoacetate + NADH.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF145230; AAD33952.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AM260479; CAJ92474.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_725842.1; -.

3D structure databases

HSSP

Q93X62; 1EDO. [HSSP ENTRY / PDB]

ModBase

Q9X6U2.

Family and domain databases

InterPro

IPR011294; 3-OHbutyrate_DHase.
IPR002198; DHase_sc/Rdtase_SDR.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01963; PHB_DH; 1.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

Q9X6U2.

Genome annotation databases

GeneID

4249460; -.

GenomeReviews

AM260479_GR; H16_A1334.

KEGG

reh:H16_A1334; -.

Phylogenomic databases

HOGENOM

Q9X6U2; -.

Genome annotation databases

CMR

Q9X6U2; H16_A1334.

Other

ProtoNet

Q9X6U2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 258`	`258`	`D-beta-hydroxybutyrate dehydrogenase.`	`PRO_0000054527`
`NP_BIND`	`8 32`	`25`	`NAD (By similarity).`
`ACT_SITE`	`153 153`		`Proton acceptor (By similarity).`
`BINDING`	`140 140`		`Substrate (By similarity).`
`CONFLICT`	`236 236`		`L -> Q (in Ref. 1; AAD33952).`

Sequence information

Length: 258 AA [This is the length of the unprocessed precursor]

Molecular weight: 26999 Da [This is the MW of the unprocessed precursor]

CRC64: 0B9A06D6CD97EF35 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLNGKTALVT GSTSGIGLGI AKALAAQGAN IIVNGFGDAD AAKAEIAQAG QGIRVGYHGA 

        70         80         90        100        110        120 
DMSKAAEIED MMRYAQSDFG GADILVNNAG IQHVAAIEDF PPERWDAIIA INLTSAFHTT 

       130        140        150        160        170        180 
RLALPGMKQK DWGRIINVAS THGLVASAQK SAYVAAKHGI VGFTKVTALE TAQTGVTANA 

       190        200        210        220        230        240 
ICPGWVLTPL VQKQVEARAQ KEGIPVEQAK RELVLEKQPS GQFVTPDELG ALAVFLSSEA 

       250 
ARQVRGAIWN MDGGWVAQ

Q9X6U2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools