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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Brain;
DOI=10.1038/23475; PubMed=10466725 [NCBI, ExPASy, EBI, Israel, Japan]
Young L.J.,
Nilsen R.,
Waymire K.G.,
MacGregor G.R.,
Insel T.R.;
"Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole.";
Nature 400:766-768(1999).
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[2]
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ROLE IN SOCIAL BEHAVIOR.
DOI=10.1038/nature02539; PubMed=15201909 [NCBI, ExPASy, EBI, Israel, Japan]
Lim M.M.,
Wang Z.,
Olazabal D.E.,
Ren X.,
Terwilliger E.F.,
Young L.J.;
"Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene.";
Nature 429:754-757(2004).
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- FUNCTION: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.
- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
- MISCELLANEOUS: In prairie and pine voles, the 5' regulatory region of AVPR1A contains a microsatellite region that is virtually absent from montane and meadow voles. This species-specific microsatellite polymorphism modulates gene expression in a cell-type-dependent manner and generates a great individual variability in the brain expression pattern. This polymorphism is correlated with monogamous social organization.
- MISCELLANEOUS: Prairie voles exhibit a monogamous social structure in nature, whereas closely related meadow voles are solitary and polygamous. AVPR1A is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. The partner preference formation in the socially promiscuous meadow vole is increased by AVPR1A gene transfer into the ventral forebrain.
- SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].
- WEB RESOURCE: Name=Protein Spotlight; Note=Nature's philanderers -Issue 52 of November 2004; URL="http://www.expasy.org/spotlight/back_issues/sptlt052.shtml";.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 420 AA [This is the length of the unprocessed precursor] |
Molecular weight: 47560 Da [This is the MW of the unprocessed precursor] |
CRC64: 8055B79C351E3DFE [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSFPRGSYDP AASNSSPWWP LSAEDANSSW EAAGHQKGSD PSGDVRNEEL AKLEIAVLAV
70 80 90 100 110 120
IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP
130 140 150 160 170 180
DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPTRRSRLM IAASWVLSFL
190 200 210 220 230 240
LSTPQYFIFS MIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF
250 260 270 280 290 300
ICYHIWRNVR GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT
310 320 330 340 350 360
AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY MFFSGHLLQD
370 380 390 400 410 420
CVQSFPCCQR MVQKFTKDDS DNMSRRHTSY SNNRSPTNST GTWKDSPKSS RSIRFIPVST
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Q9WTV9 in FASTA format |
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