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UniProtKB/Swiss-Prot entry Q9W7K5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_CYPCA
Primary accession number Q9W7K5
Secondary accession numbers None
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
Gene name
Name: ldha
From
Cyprinus carpio (Common carp) [TaxID: 7962] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Cyprinus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Tsoi S.C.-M., Li J.Y., Mannen H., Li S.S.-L.;
"Molecular evolution of vertebrate lactate dehydrogenase isozymes by gene duplication.";
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF076528; AAD40736.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
PDB
1V6A; X-ray; 2.30 A; A/B=1-333.[ExPASy / RCSB / EBI]
PDBsum 1V6A; -.
ModBase Q9W7K5.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q9W7K5.
Phylogenomic databases
HOVERGEN Q9W7K5; -.
Other
ProtoNet Q9W7K5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   333  332     L-lactate dehydrogenase A chain. PRO_0000168434
NP_BIND   30    58  29     NAD (By similarity). 
ACT_SITE   194   194        Proton acceptor (By similarity). 
BINDING   100   100        NAD (By similarity). 
BINDING   107   107        Substrate (By similarity). 
BINDING   139   139        NAD or substrate (By similarity). 
BINDING   170   170        Substrate (By similarity). 
BINDING   249   249        Substrate (By similarity). 
HELIX   4     8  5      
STRAND   9    11  3      
STRAND   24    27  4      
HELIX   31    42  12      
STRAND   47    52  6      
HELIX   56    67  12      
HELIX   68    72  5      
STRAND   76    80  5      
HELIX   84    87  4      
STRAND   91    95  5      
HELIX   107   128  22      
STRAND   133   136  4      
STRAND   138   140  3      
HELIX   141   152  12      
HELIX   156   158  3      
STRAND   159   161  3      
HELIX   165   179  15      
HELIX   183   185  3      
STRAND   190   195  6      
STRAND   198   200  3      
HELIX   202   204  3      
HELIX   212   215  4      
TURN   217   220  4      
HELIX   229   236  8      
HELIX   238   246  9      
HELIX   251   265  15      
STRAND   270   277  8      
STRAND   289   297  9      
STRAND   300   305  6      
HELIX   311   328  18      
Sequence information
Length: 333 AA [This is the length of the unprocessed precursor] Molecular weight: 36277 Da [This is the MW of the unprocessed precursor] CRC64: 45B15E6943AD4024 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASTKEKLIT HVSKEEPAGP TNKVTVVGVG MVGMAAAISI LLKDLTDELA LVDVMEDKLK 

        70         80         90        100        110        120 
GEAMDLQHGS LFLKTHKIVA DKDYSVTANS KVVVVTAGAR QQEGESRLNL VQRNVNIFKF 

       130        140        150        160        170        180 
IIPNIIKYSP NCILLVVSNP VDILTYVAWK LSGLPRNRVI GSGTNLDSAR FRHLMGEKLG 

       190        200        210        220        230        240 
IHPSNCHGWV IGEHGDSSVP VWSGVNVAGV FLQGLNPDMG TDKDKEDWKS VHKMVVDSAY 

       250        260        270        280        290        300 
EVIKLKGYTS WAIGMSAADL CQSILKNLRK CHPVSTLVKG MHGVNEEVFL SVPCILGNSG 

       310        320        330 
LTDVVHMTLK SDEEKQLVKS AETLWGVQKD LTL
Q9W7K5 in FASTA format

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