FUNCTION: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows moderate PA2 activity and exhibits procoagulant property.
CATALYTIC ACTIVITY: Phosphatidylcholine + H₂O = 1-acylglycerophosphocholine + a carboxylate.
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Expressed by the venom gland.
SIMILARITY: Belongs to the phospholipase A2 family. Group I subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

AF082983; AAD40975.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY027494; AAK15775.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q9DF52; 1FE5. [HSSP ENTRY / PDB]

ModBase

Q9W7J4.

Family and domain databases

InterPro

IPR016090; Phospholipase_A2.
IPR013090; Phospholipase_A2_AS.
IPR001211; Phospholipase_A2_euk.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.90.10; Phospholipase_A2; 1.

PANTHER

PTHR11716; Phospholipase_A2; 1.

Pfam

PF00068; Phospholip_A2_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00389; PHPHLIPASEA2.

ProDom

PD000303; PhospholipaseA2; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00085; PA2c; 1.
SMART graphical view of domain structure.

PROSITE

PS00119; PA2_ASP; 1.
PS00118; PA2_HIS; 1.

BLOCKS

Q9W7J4.

Phylogenomic databases

HOVERGEN

Q9W7J4; -.

Other

ProtoNet

Q9W7J4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Blood coagulation; Calcium; Direct protein sequencing; Hydrolase; Lipid degradation; Metal-binding; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`Potential.`
`PROPEP`	`20 27`	`8`		`PRO_0000022948`
`CHAIN`	`28 154`	`127`	`Phospholipase A2 1.`	`PRO_0000022949`
`ACT_SITE`	`75 75`		`By similarity.`
`ACT_SITE`	`126 126`		`By similarity.`
`METAL`	`55 55`		`Calcium; via carbonyl oxygen (By similarity).`
`METAL`	`57 57`		`Calcium; via carbonyl oxygen (By similarity).`
`METAL`	`58 58`		`Calcium; via carbonyl oxygen (By similarity).`
`METAL`	`76 76`		`Calcium (By similarity).`
`DISULFID`	`38 104`		`By similarity.`
`DISULFID`	`54 153`		`By similarity.`
`DISULFID`	`56 72`		`By similarity.`
`DISULFID`	`71 132`		`By similarity.`
`DISULFID`	`78 125`		`By similarity.`
`DISULFID`	`88 118`		`By similarity.`
`DISULFID`	`111 123`		`By similarity.`

Sequence information

Length: 154 AA [This is the length of the unprocessed precursor]

Molecular weight: 16844 Da [This is the MW of the unprocessed precursor]

CRC64: 1A50E3D04492E2C5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHPAHLLVLL GVCVSLLGAA RIPPLPLSLD DFSNLITCAN RGSRSWLDYA HYGCFCGSGG 

        70         80         90        100        110        120 
SGTPVDDLDR CCQVHDNCFG DAEKLPACNY LFSGPYWNPY SYKCNEGEIT CTDDNDECAA 

       130        140        150 
FICNCDRTAA ICFAGATYND ENFMVTIKKK NICQ

Q9W7J4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools