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UniProtKB/Swiss-Prot entry Q9UQB3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CTND2_HUMAN
Primary accession number Q9UQB3
Secondary accession numbers O00379 O15390 O43206 O43840 Q13589 Q9UM66 Q9UPM3
Integrated into Swiss-Prot on April 16, 2002
Sequence was last modified on December 20, 2005 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 74)
Name and origin of the protein
Protein name Catenin delta-2
Synonyms Delta-catenin
Neural plakophilin-related ARM-repeat protein
NPRAP
Neurojungin
GT24
Gene name
Name: CTNND2
Synonyms: NPRAP
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH PSEN1.
PubMed=9223106 [NCBI, ExPASy, EBI, Israel, Japan]
Zhou J., Liyanage U., Medina M., Ho C., Simmons A.D., Lovett M., Kosik K.S.;
"Presenilin 1 interaction in the brain with a novel member of the Armadillo family.";
NeuroReport 8:2085-2090(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
TISSUE=Brain;
DOI=10.1083/jcb.144.3.519; PubMed=9971746 [NCBI, ExPASy, EBI, Israel, Japan]
Lu Q., Paredes M., Medina M., Zhou J., Cavallo R., Peifer M., Orecchio L., Kosik K.S.;
"Delta-catenin, an adhesive junction-associated protein which promotes cell scattering.";
J. Cell Biol. 144:519-532(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH PSEN1.
TISSUE=Fetal brain;
PubMed=10208590 [NCBI, ExPASy, EBI, Israel, Japan]
Tanahashi H., Tabira T.;
"Isolation of human delta-catenin and its binding specificity with presenilin 1.";
NeuroReport 10:563-568(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02919; PubMed=15372022 [NCBI, ExPASy, EBI, Israel, Japan]
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
"The DNA sequence and comparative analysis of human chromosome 5.";
Nature 431:268-274(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 186-1225 (ISOFORM 1), AND INTERACTION WITH PSEN1.
TISSUE=Brain;
DOI=10.1046/j.1471-4159.1999.0720999.x; PubMed=10037471 [NCBI, ExPASy, EBI, Israel, Japan]
Levesque G., Yu G., Nishimura M., Zhang D.M., Levesque L., Yu H., Xu D., Liang Y., Rogaeva E.A., Ikeda M., Duthie M., Murgolo N., Wang L., VanderVere P., Bayne M.L., Strader C.D., Rommens J.M., Fraser P.E., St George-Hyslop P.H.;
"Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.";
J. Neurochem. 72:999-1008(1999).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 350-1225 (ISOFORM 1), AND ALTERNATIVE SPLICING.
TISSUE=Fetal brain;
DOI=10.1046/j.1432-0436.1997.6150293.x; PubMed=9342840 [NCBI, ExPASy, EBI, Israel, Japan]
Paffenholz R., Franke W.W.;
"Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family.";
Differentiation 61:293-304(1997).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 689-1225 (ISOFORM 1).
Fraser P.E., Levesque G., Rogaeva E.A., Yu G., St George-Hyslop P.H.;
"A novel gene from the arm family.";
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 746-1225 (ISOFORM 1).
TISSUE=Brain;
Yu W., Sarginson J., Gibbs R.A.;
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [MRNA] OF 865-1225 (ISOFORMS 1/2).
PubMed=9049630 [NCBI, ExPASy, EBI, Israel, Japan]
Simmons A.D., Overhauser J., Lovett M.;
"Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library.";
Genome Res. 7:118-127(1997).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
[11]
INTERACTION WITH RGNEF.
DOI=10.1074/jbc.M707158200; PubMed=17993462 [NCBI, ExPASy, EBI, Israel, Japan]
Kim H., Han J.-R., Park J., Oh M., James S.E., Chang S., Lu Q., Lee K.Y., Ki H., Song W.-J., Kim K.;
"Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation.";
J. Biol. Chem. 283:977-987(2008).
[12]
VARIANT [LARGE SCALE ANALYSIS] SER-1159.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U96136; AAC63103.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB013805; BAA36163.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC003089; AAB83940.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC003954; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC004633; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC004648; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC005367; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC005610; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC010433; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC010626; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC113390; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC127460; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
U81004; AAD00453.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U52351; AAB97957.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U72665; AAB68599.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF035302; AAB88185.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U52828; AAB96357.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00220032; -.
IPI00301317; -.
RefSeq NP_001323.1; -.
UniGene Hs.314543
3D structure databases
ModBase Q9UQB3.
PTM databases
PhosphoSite Q9UQB3; -.
Organism-specific databases
GeneCards GC05M011024; -.
H-InvDB HIX0024778; -.
HGNC HGNC:2516; CTNND2.
GenAtlas CTNND2.
MIM 604275; gene. [NCBI / EBI]
Orphanet 281; Monosomy 5p.
PharmGKB PA27017; -.
Gene expression databases
ArrayExpress Q9UQB3; -.
Bgee Q9UQB3; -.
CleanEx HS_CTNND2; -.
GermOnline ENSG00000169862; Homo sapiens.
Ontologies
GO
GO:0005912; Cellular component: adherens junction (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005737; Cellular component: cytoplasm (traceable author statement from ProtInc).
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from UniProtKB-KW).
GO:0007275; Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0007158; Biological process: neuron adhesion (non-traceable author statement from UniProtKB).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR011989; ARM-like.
IPR000225; Armadillo.
Graphical view of domain structure.
Gene3D G3DSA:1.25.10.10; ARM-like; 1.
Pfam PF00514; Arm; 5.
Pfam graphical view of domain structure.
SMART SM00185; ARM; 7.
SMART graphical view of domain structure.
PROSITE PS50176; ARM_REPEAT; 3.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9UQB3; -.
Genome annotation databases
Ensembl ENSG00000169862; Homo sapiens. [Contig view]
GeneID 1501; -.
KEGG hsa:1501; -.
Phylogenomic databases
HOVERGEN Q9UQB3; -.
OMA Q9UQB3; LPPAHTG.
Other
NextBio 6217; -.
SOURCE CTNND2; Homo sapiens.
ProtoNet Q9UQB3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell adhesion; Cell junction; Coiled coil; Developmental protein; Glycoprotein; Nucleus; Phosphoprotein; Polymorphism; Repeat; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1225  1225     Catenin delta-2. PRO_0000064299
REPEAT   394    438  45     ARM 1. 
REPEAT   540    579  40     ARM 2. 
REPEAT   582    621  40     ARM 3. 
REPEAT   626    666  41     ARM 4. 
REPEAT   682    724  43     ARM 5. 
REPEAT   728    773  46     ARM 6. 
REPEAT   835    875  41     ARM 7. 
REPEAT   882    921  40     ARM 8. 
REPEAT   975   1018  44     ARM 9. 
COILED   49     84  36     Potential. 
COMPBIAS   216    226  11     Poly-Pro. 
COMPBIAS   811    817  7     Poly-Lys. 
MOD_RES   32     32        Phosphoserine (By similarity). 
MOD_RES   267    267        Phosphoserine (By similarity). 
MOD_RES   276    276        Phosphoserine (By similarity). 
MOD_RES   415    415        Phosphoserine (By similarity). 
MOD_RES   474    474        Phosphoserine. 
MOD_RES   516    516        Phosphotyrosine (By similarity). 
MOD_RES   534    534        Phosphoserine (By similarity). 
MOD_RES   537    537        Phosphoserine (By similarity). 
MOD_RES   1072   1072        Phosphoserine (By similarity). 
MOD_RES   1076   1076        Phosphoserine (By similarity). 
MOD_RES   1127   1127        Phosphoserine (By similarity). 
VAR_SEQ   823    880        Missing (in isoform 2). VSP_006746
VARIANT   1159   1159  1     P -> S (in a colorectal cancer sample; somatic mutation). VAR_036162 
CONFLICT   426    426        D -> V (in Ref. 1; AAC63103). 
CONFLICT   443    443        D -> V (in Ref. 1; AAC63103). 
CONFLICT   725    725        A -> P (in Ref. 1; AAC63103). 
CONFLICT   894    894        L -> R (in Ref. 1 and 9). 
CONFLICT   909    909        V -> A (in Ref. 1 and 9). 
CONFLICT   980    980        A -> G (in Ref. 6; AAB97957). 
CONFLICT   1102   1102        A -> G (in Ref. 5 and 7). 
Sequence information
Length: 1225 AA [This is the length of the unprocessed precursor] Molecular weight: 132656 Da [This is the MW of the unprocessed precursor] CRC64: 4A24ACC3E22BFE83 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFARKPPGAA PLGAMPVPDQ PSSASEKTSS LSPGLNTSNG DGSETETTSA ILASVKEQEL 

        70         80         90        100        110        120 
QFERLTRELE AERQIVASQL ERCKLGSETG SMSSMSSAEE QFQWQSQDGQ KDIEDELTTG 

       130        140        150        160        170        180 
LELVDSCIRS LQESGILDPQ DYSTGERPSL LSQSALQLNS KPEGSFQYPA SYHSNQTLAL 

       190        200        210        220        230        240 
GETTPSQLPA RGTQARATGQ SFSQGTTSRA GHLAGPEPAP PPPPPPREPF APSLGSAFHL 

       250        260        270        280        290        300 
PDAPPAAAAA ALYYSSSTLP APPRGGSPLA APQGGSPTKL QRGGSAPEGA TYAAPRGSSP 

       310        320        330        340        350        360 
KQSPSRLAKS YSTSSPINIV VSSAGLSPIR VTSPPTVQST ISSSPIHQLS STIGTYATLS 

       370        380        390        400        410        420 
PTKRLVHASE QYSKHSQELY ATATLQRPGS LAAGSRASYS SQHGHLGPEL RALQSPEHHI 

       430        440        450        460        470        480 
DPIYEDRVYQ KPPMRSLSQS QGDPLPPAHT GTYRTSTAPS SPGVDSVPLQ RTGSQHGPQN 

       490        500        510        520        530        540 
AAAATFQRAS YAAGPASNYA DPYRQLQYCP SVESPYSKSG PALPPEGTLA RSPSIDSIQK 

       550        560        570        580        590        600 
DPREFGWRDP ELPEVIQMLQ HQFPSVQSNA AAYLQHLCFG DNKIKAEIRR QGGIQLLVDL 

       610        620        630        640        650        660 
LDHRMTEVHR SACGALRNLV YGKANDDNKI ALKNCGGIPA LVRLLRKTTD LEIRELVTGV 

       670        680        690        700        710        720 
LWNLSSCDAL KMPIIQDALA VLTNAVIIPH SGWENSPLQD DRKIQLHSSQ VLRNATGCLR 

       730        740        750        760        770        780 
NVSSAGEEAR RRMRECDGLT DALLYVIQSA LGSSEIDSKT VENCVCILRN LSYRLAAETS 

       790        800        810        820        830        840 
QGQHMGTDEL DGLLCGEANG KDAESSGCWG KKKKKKKSQD QWDGVGPLPD CAEPPKGIQM 

       850        860        870        880        890        900 
LWHPSIVKPY LTLLSECSNP DTLEGAAGAL QNLAAGSWKW SVYIRAAVRK EKGLPILVEL 

       910        920        930        940        950        960 
LRIDNDRVVC AVATALRNMA LDVRNKELIG KYAMRDLVHR LPGGNNSNNT ASKAMSDDTV 

       970        980        990       1000       1010       1020 
TAVCCTLHEV ITKNMENAKA LRDAGGIEKL VGISKSKGDK HSPKVVKAAS QVLNSMWQYR 

      1030       1040       1050       1060       1070       1080 
DLRSLYKKDG WSQYHFVASS STIERDRQRP YSSSRTPSIS PVRVSPNNRS ASAPASPREM 

      1090       1100       1110       1120       1130       1140 
ISLKERKTDY ECTGSNATYH GAKGEHTSRK DAMTAQNTGI STLYRNSYGA PAEDIKHNQV 

      1150       1160       1170       1180       1190       1200 
SAQPVPQEPS RKDYETYQPF QNSTRNYDES FFEDQVHHRP PASEYTMHLG LKSTGNYVDF 

      1210       1220 
YSAARPYSEL NYETSHYPAS PDSWV 

Q9UQB3 in FASTA format

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