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UniProtKB/Swiss-Prot entry Q9UNM6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PSD13_HUMAN
Primary accession number Q9UNM6
Secondary accession numbers O75831 Q9UNV3
Integrated into Swiss-Prot on May 15, 2002
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 64)
Name and origin of the protein
Protein name 26S proteasome non-ATPase regulatory subunit 13
Synonyms 26S proteasome regulatory subunit S11
26S proteasome regulatory subunit p40.5
Gene name
Name: PSMD13
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASN-13.
DOI=10.1016/S0378-1119(98)00309-6; PubMed=9714768 [NCBI, ExPASy, EBI, Israel, Japan]
Hori T., Kato S., Saeki M., DeMartino G.N., Slaughter C.A., Takeuchi J., Toh-e A., Tanaka K.;
"cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome.";
Gene 216:113-122(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Ting M.C., Chang L.Y.;
"Cloning of the human 26S proteasome subunit p40.5.";
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/S0014-5793(99)00403-2; PubMed=10225435 [NCBI, ExPASy, EBI, Israel, Japan]
Hoffman L., Gorbea C., Rechsteiner M.;
"Identification, molecular cloning, and characterization of subunit 11 of the human 26S proteasome.";
FEBS Lett. 449:88-92(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney, and Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASS SPECTROMETRY.
DOI=10.1021/bi061994u; PubMed=17323924 [NCBI, ExPASy, EBI, Israel, Japan]
Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.;
"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.";
Biochemistry 46:3553-3565(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB009398; BAA33214.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF107837; AAD43442.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF086708; AAC64104.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001100; AAH01100.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001747; AAH01747.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_002808.3; -.
UniGene Hs.134688
3D structure databases
ModBase Q9UNM6.
Protein-protein interaction databases
DIP DIP:27576N; -.
IntAct Q9UNM6; -.
PTM databases
PhosphoSite Q9UNM6; -.
Enzyme and pathway databases
Reactome REACT_11045; Signaling by Wnt.
REACT_152; Cell Cycle, Mitotic.
REACT_1538; Cell Cycle Checkpoints.
REACT_383; DNA Replication.
REACT_6185; HIV Infection.
REACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_9035; APC/C:Cdh1-mediated degradation of Skp2.
Organism-specific databases
H-InvDB HIX0009340; -.
HGNC HGNC:9558; PSMD13.
GenAtlas PSMD13.
MIM 603481; gene. [NCBI / EBI]
PharmGKB PA33904; -.
GeneCards Q9UNM6.
Gene expression databases
ArrayExpress Q9UNM6; -.
CleanEx HS_PSMD13; -.
GermOnline ENSG00000185627; Homo sapiens.
Ontologies
GO
GO:0005838; Cellular component: proteasome regulatory particle (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0031145; Biological process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (inferred from experiment from Reactome).
GO:0051436; Biological process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle (inferred from experiment from Reactome).
GO:0051437; Biological process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle (inferred from experiment from Reactome).
QuickGo view.
Family and domain databases
InterPro IPR000717; PCI.
Graphical view of domain structure.
Pfam PF01399; PCI; 1.
Pfam graphical view of domain structure.
SMART SM00088; PINT; 1.
SMART graphical view of domain structure.
BLOCKS Q9UNM6.
Genome annotation databases
Ensembl ENSG00000185627; Homo sapiens. [Contig view]
GeneID 5719; -.
KEGG hsa:5719; -.
Phylogenomic databases
HOVERGEN Q9UNM6; -.
Other
SOURCE PSMD13; Homo sapiens.
ProtoNet Q9UNM6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Phosphoprotein; Polymorphism; Proteasome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   376  376     26S proteasome non-ATPase regulatory subunit 13. PRO_0000173867
DOMAIN   239   335  97     PCI. 
MOD_RES   106   106        Phosphoserine. 
VARIANT   13    13  1     S -> N (in dbSNP:rs1045288 [NCBI]). VAR_024591 
VARIANT   204   204  1     G -> E (in dbSNP:rs1794108 [NCBI]). VAR_031094 
VARIANT   205   205  1     L -> F (in dbSNP:rs1794109 [NCBI]). VAR_031095 
CONFLICT   253   253        T -> I (in Ref. 3; AAC64104). 
Sequence information
Length: 376 AA [This is the length of the unprocessed precursor] Molecular weight: 42918 Da [This is the MW of the unprocessed precursor] CRC64: 069F965890AC9DD9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKDVPGFLQQ SQSSGPGQPA VWHRLEELYT KKLWHQLTLQ VLDFVQDPCF AQGDGLIKLY 

        70         80         90        100        110        120 
ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALTFLEKT REKVKSSDEA VILCKTAIGA 

       130        140        150        160        170        180 
LKLNIGDLQV TKETIEDVEE MLNNLPGVTS VHSRFYDLSS KYYQTIGNHA SYYKDALRFL 

       190        200        210        220        230        240 
GCVDIKDLPV SEQQERAFTL GLAGLLGEGV FNFGELLMHP VLESLRNTDR QWLIDTLYAF 

       250        260        270        280        290        300 
NSGNVERFQT LKTAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA 

       310        320        330        340        350        360 
KITVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQIKGMK DRLEFWCTDV 

       370 
KSMEMLVEHQ AHDILT 

Q9UNM6 in FASTA format

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