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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1074/jbc.274.33.23443; PubMed=10438522 [NCBI, ExPASy, EBI, Israel, Japan]
Abbaszade I.,
Liu R.-Q.,
Yang F.,
Rosenfeld S.A.,
Ross O.H.,
Link J.R.,
Ellis D.M.,
Tortorella M.D.,
Pratta M.A.,
Hollis J.M.,
Wynn R.,
Duke J.L.,
George H.J.,
Hillman M.C. Jr.,
Murphy K.,
Wiswall B.H.,
Copeland R.A.,
Decicco C.P.,
Bruckner R., ![]()
Nagase H.,
Ito Y.,
Newton R.C.,
Magolda R.L.,
Trzaskos J.M.,
Hollis G.F.,
Arner E.C.,
Burn T.C.;
"Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.";
J. Biol. Chem. 274:23443-23450(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS GLY-138 AND LEU-692.
DOI=10.1038/35012518; PubMed=10830953 [NCBI, ExPASy, EBI, Israel, Japan]
Hattori M.,
Fujiyama A.,
Taylor T.D.,
Watanabe H.,
Yada T.,
Park H.-S.,
Toyoda A.,
Ishii K.,
Totoki Y.,
Choi D.-K.,
Groner Y.,
Soeda E.,
Ohki M.,
Takagi T.,
Sakaki Y.,
Taudien S.,
Blechschmidt K.,
Polley A.,
Menzel U., ![]()
Delabar J.,
Kumpf K.,
Lehmann R.,
Patterson D.,
Reichwald K.,
Rump A.,
Schillhabel M.,
Schudy A.,
Zimmermann W.,
Rosenthal A.,
Kudoh J.,
Shibuya K.,
Kawasaki K.,
Asakawa S.,
Shintani A.,
Sasaki T.,
Nagamine K.,
Mitsuyama S.,
Antonarakis S.E.,
Minoshima S.,
Shimizu N.,
Nordsiek G.,
Hornischer K.,
Brandt P.,
Scharfe M.,
Schoen O.,
Desario A.,
Reichelt J.,
Kauer G.,
Bloecker H.,
Ramser J.,
Beck A.,
Klages S.,
Hennig S.,
Riesselmann L.,
Dagand E.,
Wehrmeyer S.,
Borzym K.,
Gardiner K.,
Nizetic D.,
Francis F.,
Lehrach H.,
Reinhardt R.,
Yaspo M.-L.;
"The DNA sequence of human chromosome 21.";
Nature 405:311-319(2000).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 413-930, AND VARIANT HIS-614.
TISSUE=Fetal brain;
DOI=10.1074/jbc.274.36.25555; PubMed=10464288 [NCBI, ExPASy, EBI, Israel, Japan]
Hurskainen T.L.,
Hirohata S.,
Seldin M.F.,
Apte S.S.;
"ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases.";
J. Biol. Chem. 274:25555-25563(1999).
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- FUNCTION: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
- CATALYTIC ACTIVITY: Cleaves aggrecan at the 392-Glu-|-Ala-393 site.
- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
- TISSUE SPECIFICITY: Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.
- DOMAIN: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
- DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
- PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
- SIMILARITY: Contains 1 disintegrin domain.
- SIMILARITY: Contains 1 peptidase M12B domain [view classification].
- SIMILARITY: Contains 2 TSP type-1 domains.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 930 AA [This is the length of the unprocessed precursor] |
Molecular weight: 101716 Da [This is the MW of the unprocessed precursor] |
CRC64: B64281502F28193B [This is a checksum on the sequence] |
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10 20 30 40 50 60
MLLGWASLLL CAFRLPLAAV GPAATPAQDK AGQPPTAAAA AQPRRRQGEE VQERAEPPGH
70 80 90 100 110 120
PHPLAQRRRS KGLVQNIDQL YSGGGKVGYL VYAGGRRFLL DLERDGSVGI AGFVPAGGGT
130 140 150 160 170 180
SAPWRHRSHC FYRGTVDASP RSLAVFDLCG GLDGFFAVKH ARYTLKPLLR GPWAEEEKGR
190 200 210 220 230 240
VYGDGSARIL HVYTREGFSF EALPPRASCE TPASTPEAHE HAPAHSNPSG RAALASQLLD
250 260 270 280 290 300
QSALSPAGGS GPQTWWRRRR RSISRARQVE LLLVADASMA RLYGRGLQHY LLTLASIANR
310 320 330 340 350 360
LYSHASIENH IRLAVVKVVV LGDKDKSLEV SKNAATTLKN FCKWQHQHNQ LGDDHEEHYD
370 380 390 400 410 420
AAILFTREDL CGHHSCDTLG MADVGTICSP ERSCAVIEDD GLHAAFTVAH EIGHLLGLSH
430 440 450 460 470 480
DDSKFCEETF GSTEDKRLMS SILTSIDASK PWSKCTSATI TEFLDDGHGN CLLDLPRKQI
490 500 510 520 530 540
LGPEELPGQT YDATQQCNLT FGPEYSVCPG MDVCARLWCA VVRQGQMVCL TKKLPAVEGT
550 560 570 580 590 600
PCGKGRICLQ GKCVDKTKKK YYSTSSHGNW GSWGSWGQCS RSCGGGVQFA YRHCNNPAPR
610 620 630 640 650 660
NNGRYCTGKR AIYRSCSLMP CPPNGKSFRH EQCEAKNGYQ SDAKGVKTFV EWVPKYAGVL
670 680 690 700 710 720
PADVCKLTCR AKGTGYYVVF SPKVTDGTEC RPYSNSVCVR GKCVRTGCDG IIGSKLQYDK
730 740 750 760 770 780
CGVCGGDNSS CTKIVGTFNK KSKGYTDVVR IPEGATHIKV RQFKAKDQTR FTAYLALKKK
790 800 810 820 830 840
NGEYLINGKY MISTSETIID INGTVMNYSG WSHRDDFLHG MGYSATKEIL IVQILATDPT
850 860 870 880 890 900
KPLDVRYSFF VPKKSTPKVN SVTSHGSNKV GSHTSQPQWV TGPWLACSRT CDTGWHTRTV
910 920 930
QCQDGNRKLA KGCPLSQRPS AFKQCLLKKC
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Q9UNA0 in FASTA format |
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