[1]
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NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GLYCOSYLATION.
DOI=10.1038/sj.onc.1201062; PubMed=9174053 [NCBI, ExPASy, EBI, Israel, Japan]
Morris S.W.,
Naeve C.W.,
Mathew P.,
James P.L.,
Kirstein M.N.,
Cui X.,
Witte D.P.;
"ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).";
Oncogene 14:2175-2188(1997).
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[2]
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ERRATUM.
Morris S.W.,
Naeve C.W.,
Mathew P.,
James P.L.,
Kirstein M.N.,
Cui X.,
Witte D.P.;
Oncogene 15:2883-2883(1997).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ARG-1491 AND GLU-1529.
DOI=10.1038/sj.onc.1200849; PubMed=9053841 [NCBI, ExPASy, EBI, Israel, Japan]
Iwahara T.,
Fujimoto J.,
Wen D.,
Cupples R.,
Bucay N.,
Arakawa T.,
Mori S.,
Ratzkin B.,
Yamamoto T.;
"Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.";
Oncogene 14:439-449(1997).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-1491 AND GLU-1529.
TISSUE=Brain;
Totoki Y.,
Toyoda A.,
Takeda T.,
Sakaki Y.,
Tanaka A.,
Yokoyama S.,
Ohara O.,
Nagase T.,
Kikuno R.F.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-1461.
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W.,
Graves T.A.,
Fulton R.S.,
Fulton L.A.,
Pepin K.H.,
Minx P.,
Wagner-McPherson C.,
Layman D.,
Wylie K.,
Sekhon M.,
Becker M.C.,
Fewell G.A.,
Delehaunty K.D.,
Miner T.L.,
Nash W.E.,
Kremitzki C.,
Oddy L.,
Du H.,
Sun H., ![]()
Bradshaw-Cordum H.,
Ali J.,
Carter J.,
Cordes M.,
Harris A.,
Isak A.,
van Brunt A.,
Nguyen C.,
Du F.,
Courtney L.,
Kalicki J.,
Ozersky P.,
Abbott S.,
Armstrong J.,
Belter E.A.,
Caruso L.,
Cedroni M.,
Cotton M.,
Davidson T.,
Desai A.,
Elliott G.,
Erb T.,
Fronick C.,
Gaige T.,
Haakenson W.,
Haglund K.,
Holmes A.,
Harkins R.,
Kim K.,
Kruchowski S.S.,
Strong C.M.,
Grewal N.,
Goyea E.,
Hou S.,
Levy A.,
Martinka S.,
Mead K.,
McLellan M.D.,
Meyer R.,
Randall-Maher J.,
Tomlinson C.,
Dauphin-Kohlberg S.,
Kozlowicz-Reilly A.,
Shah N.,
Swearengen-Shahid S.,
Snider J.,
Strong J.T.,
Thompson J.,
Yoakum M.,
Leonard S.,
Pearman C.,
Trani L.,
Radionenko M.,
Waligorski J.E.,
Wang C.,
Rock S.M.,
Tin-Wollam A.-M.,
Maupin R.,
Latreille P.,
Wendl M.C.,
Yang S.-P.,
Pohl C.,
Wallis J.W.,
Spieth J.,
Bieri T.A.,
Berkowicz N.,
Nelson J.O.,
Osborne J.,
Ding L.,
Meyer R.,
Sabo A.,
Shotland Y.,
Sinha P.,
Wohldmann P.E.,
Cook L.L.,
Hickenbotham M.T.,
Eldred J.,
Williams D.,
Jones T.A.,
She X.,
Ciccarelli F.D.,
Izaurralde E.,
Taylor J.,
Schmutz J.,
Myers R.M.,
Cox D.R.,
Huang X.,
McPherson J.D.,
Mardis E.R.,
Clifton S.W.,
Warren W.C.,
Chinwalla A.T.,
Eddy S.R.,
Marra M.A.,
Ovcharenko I.,
Furey T.S.,
Miller W.,
Eichler E.E.,
Bork P.,
Suyama M.,
Torrents D.,
Waterston R.H.,
Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
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[6]
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PARTIAL NUCLEOTIDE SEQUENCE [MRNA], AND CHROMOSOMAL TRANSLOCATION WITH NPM1.
DOI=10.1126/science.8122112; PubMed=8122112 [NCBI, ExPASy, EBI, Israel, Japan]
Morris S.W.,
Kirstein M.N.,
Valentine M.B.,
Dittmer K.G.,
Shapiro D.N.,
Saltman D.L.,
Look A.T.;
"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.";
Science 263:1281-1284(1994).
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[7]
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FUNCTION AS AN ONCOGENE.
PubMed=11387242 [NCBI, ExPASy, EBI, Israel, Japan]
Simonitsch I.,
Polgar D.,
Hajek M.,
Duchek P.,
Skrzypek B.,
Fassl S.,
Lamprecht A.,
Schmidt G.,
Krupitza G.,
Cerni C.;
"The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation.";
FASEB J. 15:1416-1418(2001).
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[8]
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CHROMOSOMAL TRANSLOCATION WITH ALO17 AND CARS.
DOI=10.1002/gcc.10033; PubMed=12112524 [NCBI, ExPASy, EBI, Israel, Japan]
Cools J.,
Wlodarska I.,
Somers R.,
Mentens N.,
Pedeutour F.,
Maes B.,
De Wolf-Peeters C.,
Pauwels P.,
Hagemeijer A.,
Marynen P.;
"Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.";
Genes Chromosomes Cancer 34:354-362(2002).
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[9]
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SUBSTRATE SPECIFICITY.
DOI=10.1021/bi0472954; PubMed=15938644 [NCBI, ExPASy, EBI, Israel, Japan]
Donella-Deana A.,
Marin O.,
Cesaro L.,
Gunby R.H.,
Ferrarese A.,
Coluccia A.M.,
Tartari C.J.,
Mologni L.,
Scapozza L.,
Gambacorti-Passerini C.,
Pinna L.A.;
"Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity.";
Biochemistry 44:8533-8542(2005).
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[10]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1078; TYR-1092; TYR-1096; TYR-1131; TYR-1278; TYR-1282; TYR-1507; TYR-1584 AND TYR-1604, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J.,
Moritz A.,
Lee K.A.,
Guo A.,
Goss V.L.,
Spek E.J.,
Zhang H.,
Zha X.-M.,
Polakiewicz R.D.,
Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
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[11]
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CHROMOSOMAL TRANSLOCATION WITH SEC31A.
DOI=10.1002/ijc.21490; PubMed=16161041 [NCBI, ExPASy, EBI, Israel, Japan]
Panagopoulos I.,
Nilsson T.,
Domanski H.A.,
Isaksson M.,
Lindblom P.,
Mertens F.,
Mandahl N.;
"Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.";
Int. J. Cancer 118:1181-1186(2006).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0507066103; PubMed=16565220 [NCBI, ExPASy, EBI, Israel, Japan]
Nousiainen M.,
Sillje H.H.W.,
Sauer G.,
Nigg E.A.,
Koerner R.;
"Phosphoproteome analysis of the human mitotic spindle.";
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1078; TYR-1096; TYR-1278; TYR-1282; TYR-1283; TYR-1359 AND TYR-1507, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[14]
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STRUCTURE BY NMR OF 1571-1589.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK.";
Submitted (APR-2008) to the PDB data bank.
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[15]
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VARIANTS [LARGE SCALE ANALYSIS] LEU-90; LEU-163; GLN-296; ALA-476; PHE-560; ILE-680; THR-704; SER-877; MET-1012; ASP-1121; THR-1274; LEU-1328; ASN-1416; LYS-1419; ARG-1429; ARG-1491 AND GLU-1529.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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