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UniProtKB/Swiss-Prot entry Q9UKR0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KLK12_HUMAN
Primary accession number Q9UKR0
Secondary accession number Q9UKR1
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 77)
Name and origin of the protein
Protein name Kallikrein-12 [Precursor]
Synonyms EC 3.4.21.-
Kallikrein-like protein 5
KLK-L5
Gene name
Name: KLK12
Synonyms: KLKL5
ORFNames: UNQ669/PRO1303
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE (ISOFORM 1).
PubMed=10652563 [NCBI, ExPASy, EBI, Israel, Japan]
Yousef G.M., Luo L.-Y., Diamandis E.P.;
"Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4.";
Anticancer Res. 19:2843-2852(1999).
[2]
NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
Yousef G.M., Magklara A., Scorilas A., Diamandis E.P.;
"Cloning of new alternatively spliced forms of the kallikrein-like gene 5 (KLK-L5).";
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/S0378-1119(00)00382-6; PubMed=11054574 [NCBI, ExPASy, EBI, Israel, Japan]
Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.;
"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.";
Gene 257:119-130(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[6]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-24, AND MASS SPECTROMETRY.
TISSUE=Milk;
DOI=10.1002/pmic.200701057; PubMed=18780401 [NCBI, ExPASy, EBI, Israel, Japan]
Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.;
"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.";
Proteomics 8:3833-3847(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF135025; AAD26426.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF135025; AAF06065.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF243527; AAG33365.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358524; AAQ88888.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC011473; AAG23258.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00007724; -.
IPI00220155; -.
RefSeq NP_665901.1; -.
UniGene Hs.411572
3D structure databases
HSSP P00760; 1EZX. [HSSP ENTRY / PDB]
ModBase Q9UKR0.
Protein family/group databases
MEROPS S01.020; -.
Organism-specific databases
GeneCards GC19M056224; -.
H-InvDB HIX0027516; -.
HGNC HGNC:6360; KLK12.
GenAtlas KLK12.
MIM 605539; gene. [NCBI / EBI]
PharmGKB PA30149; -.
Gene expression databases
ArrayExpress Q9UKR0; -.
Bgee Q9UKR0; -.
CleanEx HS_KLK12; -.
GermOnline ENSG00000186474; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (non-traceable author statement from UniProtKB).
GO:0005625; Cellular component: soluble fraction (inferred from direct assay from UniProtKB).
GO:0004252; Molecular function: serine-type endopeptidase activity (non-traceable author statement from UniProtKB).
GO:0006508; Biological process: proteolysis (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR018114; Peptidase_S1/S6_AS.
IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9UKR0; -.
Genome annotation databases
Ensembl ENSG00000186474; Homo sapiens. [Contig view]
GeneID 43849; -.
Phylogenomic databases
HOVERGEN Q9UKR0; -.
OMA Q9UKR0; GWGITNH.
Other
NextBio 53004; -.
SOURCE KLK12; Homo sapiens.
ProtoNet Q9UKR0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Disulfide bond; Glycoprotein; Hydrolase; Protease; Secreted; Serine protease; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    17  17     Potential. 
CHAIN   18   248  231     Kallikrein-12. PRO_0000027956
DOMAIN   22   246  225     Peptidase S1. 
ACT_SITE   62    62        Charge relay system (By similarity). 
ACT_SITE   108   108        Charge relay system (By similarity). 
ACT_SITE   200   200        Charge relay system (By similarity). 
CARBOHYD   24    24        N-linked (GlcNAc...). 
CARBOHYD   163   163        N-linked (GlcNAc...) (Potential). 
DISULFID   28   161        By similarity. 
DISULFID   47    63        By similarity. 
DISULFID   133   235        By similarity. 
DISULFID   140   206        By similarity. 
DISULFID   172   186        By similarity. 
DISULFID   196   222        By similarity. 
VAR_SEQ   236   248        KYVDWIRMIMRNN -> NSTLVGLGTSWNFNSCQPF (in isoform 2). VSP_005403
Sequence information
Length: 248 AA [This is the length of the unprocessed precursor] Molecular weight: 26734 Da [This is the MW of the unprocessed precursor] CRC64: BB473E98F8BAF703 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV LIDHRWVLTA 

        70         80         90        100        110        120 
AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG ASTSHEHDLR LLRLRLPVRV 

       130        140        150        160        170        180 
TSSVQPLPLP NDCATAGTEC HVSGWGITNH PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI 

       190        200        210        220        230        240 
TSNMVCAGGV PGQDACQGDS GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW 


IRMIMRNN 

Q9UKR0 in FASTA format

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