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UniProtKB/Swiss-Prot entry Q9UKK3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PARP4_HUMAN
Primary accession number Q9UKK3
Secondary accession numbers O75903 Q14682 Q9H1M6
Integrated into Swiss-Prot on September 26, 2001
Sequence was last modified on September 26, 2001 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 92)
Name and origin of the protein
Protein name Poly [ADP-ribose] polymerase 4
Synonyms PARP-4
EC 2.4.2.30
Vault poly(ADP-ribose) polymerase
VPARP
193 kDa vault protein
PARP-related/IalphaI-related H5/proline-rich
PH5P
Gene name
Name: PARP4
Synonyms: ADPRTL1, KIAA0177, PARPL
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 306-319, AND VARIANT THR-899.
DOI=10.1083/jcb.146.5.917; PubMed=10477748 [NCBI, ExPASy, EBI, Israel, Japan]
Kickhoefer V.A., Siva A.C., Kedersha N.L., Inman E.M., Ruland C., Streuli M., Rome L.H.;
"The 193 kDa vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.";
J. Cell Biol. 146:917-928(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ASN-873; ALA-1265 AND ARG-1280.
TISSUE=Thymus;
DOI=10.1006/geno.1999.6024; PubMed=10644454 [NCBI, ExPASy, EBI, Israel, Japan]
Still I.H., Vince P., Cowell J.K.;
"Identification of a novel gene (ADPRTL1) encoding a potential poly(ADP-ribosyl)transferase protein.";
Genomics 62:533-536(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-873; ALA-1265 AND ARG-1280.
TISSUE=Bone marrow;
DOI=10.1093/dnares/3.1.17; PubMed=8724849 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.;
"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.";
DNA Res. 3:17-24(1996).
[4]
SEQUENCE REVISION.
Ohara O., Nagase T., Kikuno R., Nomura N.;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02379; PubMed=15057823 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
"The DNA sequence and analysis of human chromosome 13.";
Nature 428:522-528(2004).
[6]
DISCUSSION OF SEQUENCE.
DOI=10.1016/S0014-5793(99)00173-8; PubMed=10100603 [NCBI, ExPASy, EBI, Israel, Japan]
Jean L., Risler J.-L., Nagase T., Coulouarn C., Nomura N., Salier J.-P.;
"The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?";
FEBS Lett. 446:6-8(1999).
[7]
ASSOCIATION WITH TEP1.
DOI=10.1074/jbc.274.46.32712; PubMed=10551828 [NCBI, ExPASy, EBI, Israel, Japan]
Kickhoefer V.A., Stephen A.G., Harrington L., Robinson M.O., Rome L.H.;
"Vaults and telomerase share a common subunit, TEP1.";
J. Biol. Chem. 274:32712-32717(1999).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1629, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1335, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-101; SER-1236; SER-1335; SER-1504 AND SER-1507, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF158255; AAD47250.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF057160; AAC62491.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D79999; BAA11494.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL359763; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
IPI IPI00296909; -.
RefSeq NP_006428.2; -.
UniGene Hs.591227
3D structure databases
HSSP O88554; 1GS0. [HSSP ENTRY / PDB]
ModBase Q9UKK3.
PTM databases
PhosphoSite Q9UKK3; -.
Enzyme and pathway databases
BRENDA 2.4.2.30; 247.
Organism-specific databases
GeneCards GC13M023893; -.
H-InvDB HIX0017241; -.
HGNC HGNC:271; PARP4.
GenAtlas PARP4.
MIM 607519; gene. [NCBI / EBI]
PharmGKB PA24591; -.
HUGE KIAA0177.
Gene expression databases
ArrayExpress Q9UKK3; -.
Bgee Q9UKK3; -.
CleanEx HS_PARP4; -.
GermOnline ENSG00000102699; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005634; Cellular component: nucleus (non-traceable author statement from UniProtKB).
GO:0030529; Cellular component: ribonucleoprotein complex (non-traceable author statement from UniProtKB).
GO:0003677; Molecular function: DNA binding (traceable author statement from ProtInc).
GO:0019899; Molecular function: enzyme binding (inferred from direct assay from MGI).
GO:0003950; Molecular function: NAD+ ADP-ribosyltransferase activity (non-traceable author statement from UniProtKB).
GO:0008219; Biological process: cell death (inferred from mutant phenotype from UniProtKB).
GO:0006281; Biological process: DNA repair (non-traceable author statement from UniProtKB).
GO:0006954; Biological process: inflammatory response (inferred from mutant phenotype from UniProtKB).
GO:0006471; Biological process: protein amino acid ADP-ribosylation (non-traceable author statement from UniProtKB).
GO:0042493; Biological process: response to drug (non-traceable author statement from UniProtKB).
GO:0006810; Biological process: transport (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001357; BRCT.
IPR012317; PARP_catalytic.
IPR004102; PARP_reg.
IPR013694; VIT.
IPR006587; VIT_met.
IPR002035; VWF_A.
Graphical view of domain structure.
Gene3D G3DSA:1.20.142.10; PARP_reg; 1.
Pfam PF00533; BRCT; 1.
PF00644; PARP; 1.
PF08487; VIT; 1.
PF00092; VWA; 1.
Pfam graphical view of domain structure.
SMART SM00292; BRCT; 1.
SM00609; VIT; 1.
SM00327; VWA; 1.
SMART graphical view of domain structure.
PROSITE PS50172; BRCT; 1.
PS51060; PARP_ALPHA_HD; 1.
PS51059; PARP_CATALYTIC; 1.
PS50234; VWFA; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas Q9UKK3; -.
PRIDE Q9UKK3; -.
Genome annotation databases
Ensembl ENSG00000102699; Homo sapiens. [Contig view]
GeneID 143; -.
KEGG hsa:143; -.
Phylogenomic databases
HOGENOM Q9UKK3; -.
HOVERGEN Q9UKK3; -.
Other
NextBio 569; -.
SOURCE PARP4; Homo sapiens.
ProtoNet Q9UKK3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Direct protein sequencing; Glycosyltransferase; NAD; Nucleus; Phosphoprotein; Polymorphism; Ribonucleoprotein; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1724  1724     Poly [ADP-ribose] polymerase 4. PRO_0000211330
DOMAIN   1     94  94     BRCT. 
DOMAIN   242    370  129     PARP alpha-helical. 
DOMAIN   369    573  205     PARP catalytic. 
DOMAIN   876   1046  171     VWFA. 
REGION   1562   1724  163     Interaction with the major vault protein. 
MOTIF   19     25  7     Nuclear localization signal (Potential). 
MOTIF   1237   1249  13     Nuclear localization signal (Potential). 
MOD_RES   101    101        Phosphothreonine. 
MOD_RES   1236   1236        Phosphoserine. 
MOD_RES   1335   1335        Phosphoserine. 
MOD_RES   1504   1504        Phosphoserine. 
MOD_RES   1507   1507        Phosphoserine. 
MOD_RES   1629   1629        Phosphothreonine. 
VARIANT   81     81  1     I -> V (in dbSNP:rs35200240 [NCBI]). VAR_056645 
VARIANT   122    122  1     S -> N (in dbSNP:rs9578751 [NCBI]). VAR_056646 
VARIANT   215    215  1     F -> Y (in dbSNP:rs9318600 [NCBI]). VAR_056647 
VARIANT   792    792  1     P -> L (in dbSNP:rs4986818 [NCBI]). VAR_056648 
VARIANT   873    873  1     S -> N (in dbSNP:rs7140044 [NCBI]). VAR_056649 
VARIANT   899    899  1     A -> T (in dbSNP:rs2275660 [NCBI]). VAR_056650 
VARIANT   991    991  1     K -> R (in dbSNP:rs34689435 [NCBI]). VAR_056651 
VARIANT   1012   1012  1     V -> I (in dbSNP:rs9581043 [NCBI]). VAR_056652 
VARIANT   1253   1253  1     S -> T (in dbSNP:rs4986822 [NCBI]). VAR_056653 
VARIANT   1265   1265  1     G -> A (in dbSNP:rs1050110 [NCBI]). VAR_016090 
VARIANT   1280   1280  1     G -> R (in dbSNP:rs13428 [NCBI]). VAR_016091 
CONFLICT   519    519        S -> P (in Ref. 1; AAD47250). 
CONFLICT   897    897        Q -> E (in Ref. 2 and 3). 
CONFLICT   936    936        A -> M (in Ref. 5). 
CONFLICT   936    936        A -> T (in Ref. 1; AAD47250). 
CONFLICT   1065   1065        A -> V (in Ref. 3 and 5). 
CONFLICT   1080   1080        R -> L (in Ref. 5). 
CONFLICT   1108   1108        C -> R (in Ref. 5). 
CONFLICT   1328   1328        T -> P (in Ref. 5). 
CONFLICT   1331   1331        T -> A (in Ref. 5). 
CONFLICT   1394   1394        A -> S (in Ref. 5). 
CONFLICT   1459   1459        Y -> S (in Ref. 5). 
CONFLICT   1550   1550        P -> L (in Ref. 5). 
CONFLICT   1555   1555        V -> L (in Ref. 1; AAD47250). 
CONFLICT   1564   1564        T -> I (in Ref. 5). 
CONFLICT   1656   1656        P -> A (in Ref. 5). 
Sequence information
Length: 1724 AA [This is the length of the unprocessed precursor] Molecular weight: 192589 Da [This is the MW of the unprocessed precursor] CRC64: A009F34934460EDC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVMGIFANCI FCLKVKYLPQ QQKKKLQTDI KENGGKFSFS LNPQCTHIIL DNADVLSQYQ 

        70         80         90        100        110        120 
LNSIQKNHVH IANPDFIWKS IREKRLLDVK NYDPYKPLDI TPPPDQKASS SEVKTEGLCP 

       130        140        150        160        170        180 
DSATEEEDTV ELTEFGMQNV EIPHLPQDFE VAKYNTLEKV GMEGGQEAVV VELQCSRDSR 

       190        200        210        220        230        240 
DCPFLISSHF LLDDGMETRR QFAIKKTSED ASEYFENYIE ELKKQGFLLR EHFTPEATQL 

       250        260        270        280        290        300 
ASEQLQALLL EEVMNSSTLS QEVSDLVEMI WAEALGHLEH MLLKPVNRIS LNDVSKAEGI 

       310        320        330        340        350        360 
LLLVKAALKN GETAEQLQKM MTEFYRLIPH KGTMPKEVNL GLLAKKADLC QLIRDMVNVC 

       370        380        390        400        410        420 
ETNLSKPNPP SLAKYRALRC KIEHVEQNTE EFLRVRKEVL QNHHSKSPVD VLQIFRVGRV 

       430        440        450        460        470        480 
NETTEFLSKL GNVRPLLHGS PVQNIVGILC RGLLLPKVVE DRGVQRTDVG NLGSGIYFSD 

       490        500        510        520        530        540 
SLSTSIKYSH PGETDGTRLL LICDVALGKC MDLHEKDFSL TEAPPGYDSV HGVSQTASVT 

       550        560        570        580        590        600 
TDFEDDEFVV YKTNQVKMKY IIKFSMPGDQ IKDFHPSDHT ELEEYRPEFS NFSKVEDYQL 

       610        620        630        640        650        660 
PDAKTSSSTK AGLQDASGNL VPLEDVHIKG RIIDTVAQVI VFQTYTNKSH VPIEAKYIFP 

       670        680        690        700        710        720 
LDDKAAVCGF EAFINGKHIV GEIKEKEEAQ QEYLEAVTQG HGAYLMSQDA PDVFTVSVGN 

       730        740        750        760        770        780 
LPPKAKVLIK ITYITELSIL GTVGVFFMPA TVAPWQQDKA LNENLQDTVE KICIKEIGTK 

       790        800        810        820        830        840 
QSFSLTMSIE MPYVIEFIFS DTHELKQKRT DCKAVISTME GSSLDSSGFS LHIGLSAAYL 

       850        860        870        880        890        900 
PRMWVEKHPE KESEACMLVF QPDLDVDLPD LASESEVIIC LDCSSSMEGV TFLQAKQIAL 

       910        920        930        940        950        960 
HALSLVGEKQ KVNIIQFGTG YKELFSYPKH ITSNTAAAEF IMSATPTMGN TDFWKTLRYL 

       970        980        990       1000       1010       1020 
SLLYPARGSR NILLVSDGHL QDESLTLQLV KRSRPHTRLF ACGIGSTANR HVLRILSQCG 

      1030       1040       1050       1060       1070       1080 
AGVFEYFNAK SKHSWRKQIE DQMTRLCSPS CHSVSVKWQQ LNPDAPEALQ APAQVPSLFR 

      1090       1100       1110       1120       1130       1140 
NDRLLVYGFI PHCTQATLCA LIQEKEFCTM VSTTELQKTT GTMIHKLAAR ALIRDYEDGI 

      1150       1160       1170       1180       1190       1200 
LHENETSHEM KKQTLKSLII KLSKENSLIT QFTSFVAVEK RDENESPFPD IPKVSELIAK 

      1210       1220       1230       1240       1250       1260 
EDVDFLPYMS WQGEPQEAVR NQSLLASSEW PELRLSKRKH RKIPFSKRKM ELSQPEVSED 

      1270       1280       1290       1300       1310       1320 
FEEDGLGVLP AFTSNLERGG VEKLLDLSWT ESCKPTATEP LFKKVSPWET STSSFFPILA 

      1330       1340       1350       1360       1370       1380 
PAVGSYLTPT TRAHSPASLS FASYRQVASF GSAAPPRQFD ASQFSQGPVP GTCADWIPQS 

      1390       1400       1410       1420       1430       1440 
ASCPTGPPQN PPSAPYCGIV FSGSSLSSAQ SAPLQHPGGF TTRPSAGTFP ELDSPQLHFS 

      1450       1460       1470       1480       1490       1500 
LPTDPDPIRG FGSYHPSAYS PFHFQPSAAS LTANLRLPMA SALPEALCSQ SRTTPVDLCL 

      1510       1520       1530       1540       1550       1560 
LEESVGSLEG SRCPVFAFQS SDTESDELSE VLQDSCFLQI KCDTKDDSIP CFLEVKEEDE 

      1570       1580       1590       1600       1610       1620 
IVCTQHWQDA VPWTELLSLQ TEDGFWKLTP ELGLILNLNT NGLHSFLKQK GIQSLGVKGR 

      1630       1640       1650       1660       1670       1680 
ECLLDLIATM LVLQFIRTRL EKEGIVFKSL MKMDDPSISR NIPWAFEAIK QASEWVRRTE 

      1690       1700       1710       1720 
GQYPSICPRL ELGNDWDSAT KQLLGLQPIS TVSPLHRVLH YSQG 

Q9UKK3 in FASTA format

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