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UniProtKB/Swiss-Prot entry Q9UKB3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DJC12_HUMAN
Primary accession number Q9UKB3
Secondary accession number Q9UKB2
Integrated into Swiss-Prot on February 1, 2003
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 68)
Name and origin of the protein
Protein name DnaJ homolog subfamily C member 12
Synonym J domain-containing protein 1
Gene name
Name: DNAJC12
Synonyms: JDP1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
DOI=10.1016/S0167-4781(00)00047-6; PubMed=10760603 [NCBI, ExPASy, EBI, Israel, Japan]
Lee J., Hahn Y., Yun J.H., Mita K., Chung J.H.;
"Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths.";
Biochim. Biophys. Acta 1491:355-363(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[5]
STRUCTURE BY NMR OF 1-100.
RIKEN structural genomics initiative (RSGI);
"Solution structure of J-domain from human DnaJ subfamily C member 12.";
Submitted (NOV-2005) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF176012; AAD52650.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF176013; AAD52651.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL133551; CAC04172.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC017018; AAH17018.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00029149; -.
IPI00220169; -.
RefSeq NP_068572.1; -.
NP_957714.1; -.
UniGene Hs.260720
3D structure databases
PDB
2CTQ; NMR; -; A=1-99.[ExPASy / RCSB / EBI]
PDBsum 2CTQ; -.
ModBase Q9UKB3.
PTM databases
PhosphoSite Q9UKB3; -.
Organism-specific databases
GeneCards GC10M069226; -.
H-InvDB HIX0008866; -.
HGNC HGNC:28908; DNAJC12.
GenAtlas DNAJC12.
MIM 606060; gene. [NCBI / EBI]
PharmGKB PA134931354; -.
Gene expression databases
ArrayExpress Q9UKB3; -.
Bgee Q9UKB3; -.
CleanEx HS_DNAJC12; -.
GermOnline ENSG00000108176; Homo sapiens.
Ontologies
GO
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
Pfam graphical view of domain structure.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; FALSE_NEG.
PS50076; DNAJ_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9UKB3; -.
Genome annotation databases
Ensembl ENSG00000108176; Homo sapiens. [Contig view]
GeneID 56521; -.
KEGG hsa:56521; -.
Phylogenomic databases
HOGENOM Q9UKB3; -.
HOVERGEN Q9UKB3; -.
OMA Q9UKB3; RGKKDLM.
Other
NextBio 62025; -.
SOURCE DNAJC12; Homo sapiens.
ProtoNet Q9UKB3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Chaperone; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   198  198     DnaJ homolog subfamily C member 12. PRO_0000071066
DOMAIN   14    79  66     J. 
VAR_SEQ   100   107        SMHWVVRG -> VGFSLGAT (in isoform B). VSP_001295
VAR_SEQ   108   198        Missing (in isoform B). VSP_001296
VARIANT   124   124  1     M -> I (in dbSNP:rs35690028 [NCBI]). VAR_048913 
VARIANT   129   129  1     C -> W (in dbSNP:rs36099123 [NCBI]). VAR_048914 
HELIX   15    18  4      
HELIX   27    39  13      
TURN   43    45  3      
HELIX   52    67  16      
HELIX   69    81  13      
HELIX   87    95  9      
Sequence information
Length: 198 AA [This is the length of the unprocessed precursor] Molecular weight: 23415 Da [This is the MW of the unprocessed precursor] CRC64: 03429472C61413EB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDAILNYRSE DTEDYYTLLG CDELSSVEQI LAEFKVRALE CHPDKHPENP KAVETFQKLQ 

        70         80         90        100        110        120 
KAKEILTNEE SRARYDHWRR SQMSMPFQQW EALNDSVKTS MHWVVRGKKD LMLEESDKTH 

       130        140        150        160        170        180 
TTKMENEECN EQRERKKEEL ASTAEKTEQK EPKPLEKSVS PQNSDSSGFA DVNGWHLRFR 

       190 
WSKDAPSELL RKFRNYEI 

Q9UKB3 in FASTA format

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