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UniProtKB/Swiss-Prot entry Q9UI26


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IPO11_HUMAN
Primary accession number Q9UI26
Secondary accession numbers A6NGJ5 Q8N5R2 Q9NSJ6 Q9NVB1
Integrated into Swiss-Prot on July 19, 2004
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 61)
Name and origin of the protein
Protein name Importin-11
Synonyms Imp11
Ran-binding protein 11
RanBP11
Gene name
Name: IPO11
Synonyms: RANBP11
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Goerlich D., Prehn S., Hartmann E.;
"Human RanBP11.";
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02919; PubMed=15372022 [NCBI, ExPASy, EBI, Israel, Japan]
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
"The DNA sequence and comparative analysis of human chromosome 5.";
Nature 431:268-274(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 816-975.
TISSUE=Testis;
DOI=10.1186/1471-2164-8-399; PubMed=17974005 [NCBI, ExPASy, EBI, Israel, Japan]
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[7]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH UBE2E3.
DOI=10.1093/emboj/19.20.5502; PubMed=11032817 [NCBI, ExPASy, EBI, Israel, Japan]
Plafker S.M., Macara I.G.;
"Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2.";
EMBO J. 19:5502-5513(2000).
[8]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
  • FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).
  • SUBUNIT: Interacts with UBE2E3 and RPL12.
  • INTERACTION:
    Q9BUV8:C20orf24; NbExp=1; IntAct=EBI-748752, EBI-1050079;
  • SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
  • SIMILARITY: Belongs to the importin beta family.
  • SIMILARITY: Contains 15 HEAT repeats.
  • SIMILARITY: Contains 1 importin N-terminal domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF111109; AAF21936.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK001696; BAA91843.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC008859; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
CH471137; EAW51379.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC031694; AAH31694.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033776; AAH33776.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL162083; CAB82416.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00301107; -.
PIR T47185; T47185.
RefSeq NP_057422.3; -.
UniGene Hs.482269
3D structure databases
ModBase Q9UI26.
Protein-protein interaction databases
IntAct Q9UI26; 8.
Organism-specific databases
GeneCards GC05P061744; -.
H-InvDB HIX0020778; -.
HGNC HGNC:20628; IPO11.
GenAtlas IPO11.
MIM 610889; gene. [NCBI / EBI]
PharmGKB PA134936197; -.
Gene expression databases
ArrayExpress Q9UI26; -.
Bgee Q9UI26; -.
CleanEx HS_IPO11; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005643; Cellular component: nuclear pore (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0000059; Biological process: protein import into nucleus, docking (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR011989; ARM-like.
IPR001494; Importin-b_N.
Graphical view of domain structure.
Gene3D G3DSA:1.25.10.10; ARM-like; 1.
Pfam PF03810; IBN_N; 1.
Pfam graphical view of domain structure.
PROSITE PS50077; HEAT_REPEAT; FALSE_NEG.
PS50166; IMPORTIN_B_NT; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas Q9UI26; -.
PRIDE Q9UI26; -.
Genome annotation databases
Ensembl ENSG00000086200; Homo sapiens. [Contig view]
GeneID 51194; -.
Phylogenomic databases
HOGENOM Q9UI26; -.
HOVERGEN Q9UI26; -.
Other
NextBio 54202; -.
SOURCE IPO11; Homo sapiens.
ProtoNet Q9UI26.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Nucleus; Polymorphism; Protein transport; Repeat; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   975  975     Importin-11. PRO_0000120756
DOMAIN   28   100  73     Importin N-terminal. 
REPEAT   123   160  38     HEAT 1. 
REPEAT   209   248  40     HEAT 2. 
REPEAT   318   356  39     HEAT 3. 
REPEAT   422   459  38     HEAT 4. 
REPEAT   473   509  37     HEAT 5. 
REPEAT   511   548  38     HEAT 6. 
REPEAT   555   593  39     HEAT 7. 
REPEAT   600   636  37     HEAT 8. 
REPEAT   640   677  38     HEAT 9. 
REPEAT   683   720  38     HEAT 10. 
REPEAT   743   764  22     HEAT 11. 
REPEAT   765   804  40     HEAT 12. 
REPEAT   819   849  31     HEAT 13. 
REPEAT   850   887  38     HEAT 14. 
REPEAT   957   974  18     HEAT 15. 
VARIANT   260   260  1     N -> D (in dbSNP:rs35107530 [NCBI]). VAR_050004 
VARIANT   937   937  1     I -> V (in dbSNP:rs11544795 [NCBI]). VAR_050005 
CONFLICT   204   204        I -> T (in Ref. 2; BAA91843). 
CONFLICT   504   504        I -> V (in Ref. 2; BAA91843). 
CONFLICT   571   571        V -> A (in Ref. 2; BAA91843). 
Sequence information
Length: 975 AA [This is the length of the unprocessed precursor] Molecular weight: 112535 Da [This is the MW of the unprocessed precursor] CRC64: 6A9349B2F8F36DF9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDLNSASTVV LQVLTQATSQ DTAVLKPAEE QLKQWETQPG FYSVLLNIFT NHTLDINVRW 

        70         80         90        100        110        120 
LAVLYFKHGI DRYWRRVAPH ALSEEEKTTL RAGLITNFNE PINQIATQIA VLIAKVARLD 

       130        140        150        160        170        180 
CPRQWPELIP TLIESVKVQD DLRQHRALLT FYHVTKTLAS KRLAADRKLF YDLASGIYNF 

       190        200        210        220        230        240 
ACSLWNHHTD TFLQEVSSGN EAAILSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMGFLH 

       250        260        270        280        290        300 
GIFERLKQFL ECSRSIGTDN VCRDRLEKTI ILFTKVLLDF LDQHPFSFTP LIQRSLEFSV 

       310        320        330        340        350        360 
SYVFTEVGEG VTFERFIVQC MNLIKMIVKN YAYKPSKNFE DSSPETLEAH KIKMAFFTYP 

       370        380        390        400        410        420 
TLTEICRRLV SHYFLLTEEE LTMWEEDPEG FTVEETGGDS WKYSLRPCTE VLFIDIFHEY 

       430        440        450        460        470        480 
NQTLTPVLLE MMQTLQGPTN VEDMNALLIK DAVYNAVGLA AYELFDSVDF DQWFKNQLLP 

       490        500        510        520        530        540 
ELQVIHNRYK PLRRRVIWLI GQWISVKFKS DLRPMLYEAI CNLLQDQDLV VRIETATTLK 

       550        560        570        580        590        600 
LTVDDFEFRT DQFLPYLETM FTLLFQLLQQ VTECDTKMHV LHVLSCVIER VNMQIRPYVG 

       610        620        630        640        650        660 
CLVQYLPLLW KQSEEHNMLR CAILTTLIHL VQGLGADSKN LYPFLLPVIQ LSTDVSQPPH 

       670        680        690        700        710        720 
VYLLEDGLEL WLVTLENSPC ITPELLRIFQ NMSPLLELSS ENLRTCFKII NGYIFLSSTE 

       730        740        750        760        770        780 
FLQTYAVGLC QSFCELLKEI TTEGQVQVLK VVENALKVNP ILGPQMFQPI LPYVFKGIIE 

       790        800        810        820        830        840 
GERYPVVMST YLGVMGRVLL QNTSFFSSLL NEMAHKFNQE MDQLLGNMIE MWVDRMDNIT 

       850        860        870        880        890        900 
QPERRKLSAL ALLSLLPSDN SVIQDKFCGI INISVEGLHD VMTEDPETGT YKDCMLMSHL 

       910        920        930        940        950        960 
EEPKVTEDEE PPTEQDKRKK MLALKDPVHT VSLQQFIYEK LKAQQEMLGE QGFQSLMETV 

       970 
DTEIVTQLQE FLQGF 

Q9UI26 in FASTA format

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