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UniProtKB/Swiss-Prot entry Q9UHQ4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BAP29_HUMAN
Primary accession number Q9UHQ4
Secondary accession number O95003
Integrated into Swiss-Prot on November 8, 2002
Sequence was last modified on November 8, 2002 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 60)
Name and origin of the protein
Protein name B-cell receptor-associated protein 29
Synonym BCR-associated protein Bap29
Gene name
Name: BCAP29
Synonyms: BAP29
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Adrenal gland;
DOI=10.1073/pnas.160270997; PubMed=10931946 [NCBI, ExPASy, EBI, Israel, Japan]
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
  • FUNCTION: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity).
  • SUBUNIT: Homodimer and heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II (By similarity).
  • SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
  • SIMILARITY: Belongs to the BCAP29/BCAP31 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF126020; AAF17230.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006981; AAP35627.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004839; AAC83971.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008478; AAH08478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00221233; -.
RefSeq NP_001008405.1; -.
NP_001008406.1; -.
NP_001008407.1; -.
NP_061332.2; -.
UniGene Hs.303787
3D structure databases
ModBase Q9UHQ4.
Organism-specific databases
GeneCards GC07P107007; -.
HGNC HGNC:24131; BCAP29.
GenAtlas BCAP29.
PharmGKB PA134939094; -.
Gene expression databases
ArrayExpress Q9UHQ4; -.
Bgee Q9UHQ4; -.
CleanEx HS_BCAP29; -.
GermOnline ENSG00000075790; Homo sapiens.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0006915; Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
GO:0006886; Biological process: intracellular protein transport (inferred from electronic annotation from InterPro).
GO:0016192; Biological process: vesicle-mediated transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR008417; Bap31.
Graphical view of domain structure.
PANTHER PTHR12701; Bap31; 1.
Pfam PF05529; Bap31; 1.
Pfam graphical view of domain structure.
Proteomic databases
PRIDE Q9UHQ4; -.
Genome annotation databases
Ensembl ENSG00000075790; Homo sapiens. [Contig view]
GeneID 55973; -.
KEGG hsa:55973; -.
Phylogenomic databases
HOVERGEN Q9UHQ4; -.
Other
NextBio 61415; -.
ProtoNet Q9UHQ4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Apoptosis; Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   241  241     B-cell receptor-associated protein 29. PRO_0000142888
TOPO_DOM   1     6  6     Lumenal (Potential). 
TRANSMEM   7    27  21     Potential. 
TOPO_DOM   28    43  16     Cytoplasmic (Potential). 
TRANSMEM   44    64  21     Potential. 
TOPO_DOM   65   103  39     Lumenal (Potential). 
TRANSMEM   104   124  21     Potential. 
TOPO_DOM   125   241  117     Cytoplasmic (Potential). 
MOTIF   238   241  4     Di-lysine motif. 
CONFLICT   25    25        P -> L (in Ref. 1; AAF17230). 
CONFLICT   105   106        YI -> SIL (in Ref. 1; AAF17230). 
CONFLICT   131   131        L -> R (in Ref. 1; AAF17230). 
Sequence information
Length: 241 AA [This is the length of the unprocessed precursor] Molecular weight: 28320 Da [This is the MW of the unprocessed precursor] CRC64: 964C39A53E072274 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK AFLTIIILLI 

        70         80         90        100        110        120 
VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS QRNLYISGFS LFFWLVLRRL 

       130        140        150        160        170        180 
VTLITQLAKE LSNKGVLKTQ AENTNKAAKK FMEENEKLKR ILKSHGKDEE CVLEAENKKL 

       190        200        210        220        230        240 
VEDQEKLKTE LRKTSDALSK AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR 


L 

Q9UHQ4 in FASTA format

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