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UniProtKB/Swiss-Prot entry Q9UBX7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KLK11_HUMAN
Primary accession number Q9UBX7
Secondary accession numbers O75837 Q9NS65
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on February 21, 2006 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 89)
Name and origin of the protein
Protein name Kallikrein-11 [Precursor]
Synonyms hK11
EC 3.4.21.-
Hippostasin
Trypsin-like protease
Serine protease 20
Contains Kallikrein-11 inactive chain 1
Kallikrein-11 inactive chain 2
Gene name
Name: KLK11
Synonyms: PRSS20, TLSP
ORFNames: UNQ649/PRO1279
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Hippocampus;
DOI=10.1016/S0167-4781(98)00116-X; PubMed=9765601 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshida S., Taniguchi M., Suemoto T., Oka T., He X.P., Shiosaka S.;
"cDNA cloning and expression of a novel serine protease, TLSP.";
Biochim. Biophys. Acta 1399:225-228(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Hippocampus, and Prostate;
DOI=10.1006/bbrc.2000.2761; PubMed=10872828 [NCBI, ExPASy, EBI, Israel, Japan]
Mitsui S., Yamada T., Okui A., Kominami K., Uemura H., Yamaguchi N.;
"A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate.";
Biochem. Biophys. Res. Commun. 272:205-211(2000).
[3]
NUCLEOTIDE SEQUENCE (ISOFORM 1).
DOI=10.1006/geno.1999.6072; PubMed=10662548 [NCBI, ExPASy, EBI, Israel, Japan]
Yousef G.M., Scorilas A., Diamandis E.P.;
"Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family.";
Genomics 63:88-96(2000).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/S0378-1119(00)00382-6; PubMed=11054574 [NCBI, ExPASy, EBI, Israel, Japan]
Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.;
"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.";
Gene 257:119-130(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
FUNCTION, PROCESSING, AND TISSUE SPECIFICITY.
DOI=10.1158/1078-0432.CCR-05-1696; PubMed=16467084 [NCBI, ExPASy, EBI, Israel, Japan]
Luo L.Y., Shan S.J., Elliott M.B., Soosaipillai A., Diamandis E.P.;
"Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma.";
Clin. Cancer Res. 12:742-750(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB012917; BAA33404.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB013730; BAA88713.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB041036; BAA96797.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF164623; AAD47815.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF243527; AAG33364.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359014; AAQ89373.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC011473; AAG23257.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022068; AAH22068.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00002818; -.
IPI00218137; -.
RefSeq NP_006844.1; -.
NP_659196.1; -.
UniGene Hs.57771
3D structure databases
HSSP P00760; 1EZX. [HSSP ENTRY / PDB]
ModBase Q9UBX7.
Protein family/group databases
MEROPS S01.257; -.
Organism-specific databases
GeneCards GC19M056217; -.
H-InvDB HIX0015375; -.
HGNC HGNC:6359; KLK11.
GenAtlas KLK11.
MIM 604434; gene. [NCBI / EBI]
PharmGKB PA30148; -.
Gene expression databases
ArrayExpress Q9UBX7; -.
Bgee Q9UBX7; -.
CleanEx HS_KLK11; -.
GermOnline ENSG00000167757; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004252; Molecular function: serine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR018114; Peptidase_S1/S6_AS.
IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9UBX7; -.
Genome annotation databases
Ensembl ENSG00000167757; Homo sapiens. [Contig view]
GeneID 11012; -.
Phylogenomic databases
HOGENOM Q9UBX7; -.
HOVERGEN Q9UBX7; -.
OMA Q9UBX7; NITDTMV.
Other
NextBio 41831; -.
PMAP-CutDB Q9UBX7; -.
SOURCE KLK11; Homo sapiens.
ProtoNet Q9UBX7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Disulfide bond; Glycoprotein; Hydrolase; Polymorphism; Protease; Secreted; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    50  50     Potential. 
PROPEP   51    53  3     Activation peptide (Potential). PRO_0000027954
CHAIN   54   282  229     Kallikrein-11. PRO_0000027955
CHAIN   54   188  135     Kallikrein-11 inactive chain 1. PRO_0000302061
CHAIN   189   282  94     Kallikrein-11 inactive chain 2. PRO_0000302062
DOMAIN   53   280  228     Peptidase S1. 
ACT_SITE   94    94        Charge relay system (By similarity). 
ACT_SITE   142   142        Charge relay system (By similarity). 
ACT_SITE   235   235        Charge relay system (By similarity). 
CARBOHYD   131   131        N-linked (GlcNAc...) (Potential). 
CARBOHYD   197   197        N-linked (GlcNAc...) (Potential). 
CARBOHYD   213   213        N-linked (GlcNAc...) (Potential). 
CARBOHYD   242   242        N-linked (GlcNAc...) (Potential). 
DISULFID   60   195        By similarity. 
DISULFID   79    95        By similarity. 
DISULFID   167   269        By similarity. 
DISULFID   174   241        By similarity. 
DISULFID   206   220        By similarity. 
DISULFID   231   256        By similarity. 
VAR_SEQ   1    32        Missing (in isoform 1). VSP_005402
VARIANT   32    32  1     A -> T (in dbSNP:rs2288892 [NCBI]). VAR_051856 
VARIANT   49    49  1     G -> E (in dbSNP:rs3745539 [NCBI]). VAR_021943 
VARIANT   166   166  1     R -> C (in dbSNP:rs1048328 [NCBI]). VAR_024296 
Sequence information
Length: 282 AA [This is the length of the unprocessed precursor] Molecular weight: 31059 Da [This is the MW of the unprocessed precursor] CRC64: B442DDE613EE0A17 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG ETRIIKGFEC 

        70         80         90        100        110        120 
KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY IVHLGQHNLQ KEEGCEQTRT 

       130        140        150        160        170        180 
ATESFPHPGF NNSLPNKDHR NDIMLVKMAS PVSITWAVRP LTLSSRCVTA GTSCLISGWG 

       190        200        210        220        230        240 
STSSPQLRLP HTLRCANITI IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV 

       250        260        270        280 
CNQSLQGIIS WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN 

Q9UBX7 in FASTA format

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