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UniProtKB/Swiss-Prot entry Q9UBS3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNJB9_HUMAN
Primary accession number Q9UBS3
Secondary accession numbers None
Integrated into Swiss-Prot on October 18, 2001
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    May 26, 2009 (Entry version 74)
Name and origin of the protein
Protein name DnaJ homolog subfamily B member 9
Synonyms Microvascular endothelial differentiation gene 1 protein
Mdg-1
Gene name
Name: DNAJB9
Synonyms: MDG1
ORFNames: UNQ743/PRO1471
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Ye M., Zhang Q., Fu G., Huang Q., Zhou J., Shen Y., Xu S., He K., Chen S., Mao M., Chen Z.;
"Human MDG1 gene, complete cds.";
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Seki N., Hattori A., Muramatsu M., Miyajima N., Saito T.;
"Human microvascular endothelial differentiation gene 1.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.GR1547R; PubMed=11230166 [NCBI, ExPASy, EBI, Israel, Japan]
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
STRUCTURE BY NMR OF 24-102.
RIKEN structural genomics initiative (RSGI);
"Solution structure of J-domain from human DnaJ subfamily B menber 9.";
Submitted (NOV-2005) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF083247; AAD39845.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB026908; BAA84703.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL080081; CAB45701.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359045; AAQ89404.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC028912; AAH28912.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00017608; -.
PIR T12472; T12472.
RefSeq NP_036460.1; -.
UniGene Hs.6790
3D structure databases
PDB
2CTR; NMR; -; A=26-100.[ExPASy / RCSB / EBI]
PDBsum 2CTR; -.
ModBase Q9UBS3.
Protein-protein interaction databases
IntAct Q9UBS3; 7.
Organism-specific databases
GeneCards GC07P107997; -.
H-InvDB HIX0006998; -.
HGNC HGNC:6968; DNAJB9.
GenAtlas DNAJB9.
MIM 602634; gene. [NCBI / EBI]
PharmGKB PA27419; -.
Gene expression databases
ArrayExpress Q9UBS3; -.
Bgee Q9UBS3; -.
CleanEx HS_DNAJB9; -.
GermOnline ENSG00000128590; Homo sapiens.
Ontologies
GO
GO:0005783; Cellular component: endoplasmic reticulum (inferred from direct assay from LIFEdb).
GO:0005730; Cellular component: nucleolus (inferred from sequence or structural similarity from UniProtKB).
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0051082; Molecular function: unfolded protein binding (inferred from electronic annotation from InterPro).
GO:0006457; Biological process: protein folding (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
IPR003095; Hsp_DnaJ.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
Pfam graphical view of domain structure.
PRINTS PR00625; DNAJPROTEIN.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; 1.
PS50076; DNAJ_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9UBS3; -.
Genome annotation databases
Ensembl ENSG00000128590; Homo sapiens. [Contig view]
GeneID 4189; -.
KEGG hsa:4189; -.
Phylogenomic databases
HOGENOM Q9UBS3; -.
HOVERGEN Q9UBS3; -.
OMA Q9UBS3; FNFDDLF.
Other
NextBio 16506; -.
SOURCE DNAJB9; Homo sapiens.
ProtoNet Q9UBS3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Chaperone; Cytoplasm; Nucleus; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   223  223     DnaJ homolog subfamily B member 9. PRO_0000071031
DOMAIN   26    90  65     J. 
VARIANT   136   136  1     R -> H (in dbSNP:rs17155937 [NCBI]). VAR_048911 
HELIX   27    31  5      
HELIX   39    52  14      
TURN   55    57  3      
HELIX   61    78  18      
HELIX   81    88  8      
HELIX   91    94  4      
STRAND   97    99  3      
Sequence information
Length: 223 AA [This is the length of the unprocessed precursor] Molecular weight: 25518 Da [This is the MW of the unprocessed precursor] CRC64: 59E3E57FF8B378BC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA MKYHPDKNKS 

        70         80         90        100        110        120 
PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ RGSGSSFEQS FNFNFDDLFK 

       130        140        150        160        170        180 
DFGFFGQNQN TGSKKRFENH FQTRQDGGSS RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS 

       190        200        210        220 
GFDSTNQHTV QTENRFHGSS KHCRTVTQRR GNMVTTYTDC SGQ 

Q9UBS3 in FASTA format

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