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UniProtKB/Swiss-Prot entry Q9TTK8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KCRU_BOVIN
Primary accession number Q9TTK8
Secondary accession number Q3ZCF8
Integrated into Swiss-Prot on April 27, 2001
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 47)
Name and origin of the protein
Protein name Creatine kinase, ubiquitous mitochondrial [Precursor]
Synonyms EC 2.7.3.2
U-MtCK
Acidic-type mitochondrial creatine kinase
Mia-CK
Gene name
Name: CKMT1
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Retina;
DOI=10.1006/exer.1999.0693; PubMed=10433856 [NCBI, ExPASy, EBI, Israel, Japan]
Komori N., Usukura J., Jackson K.W., Tobin S.L., Matsumoto H., Nishizawa Y.;
"Initiating ocular proteomics for cataloging bovine retinal proteins: microanalytical techniques permit the identification of proteins derived from a novel photoreceptor preparation.";
Exp. Eye Res. 69:195-212(1999).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus;
TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB003307; BAA88431.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC102422; AAI02423.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_776700.1; -.
UniGene Bt.49713
3D structure databases
HSSP P12532; 1QK1. [HSSP ENTRY / PDB]
SMR Q9TTK8; 46-412.
ModBase Q9TTK8.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004111; Molecular function: creatine kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR000749; ATP-gua_Ptrans.
IPR014746; Gln_synth/guanido_kin_cat.
Graphical view of domain structure.
Gene3D G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
PANTHER PTHR11547; ATP-gua_Ptrans; 1.
Pfam PF00217; ATP-gua_Ptrans; 1.
PF02807; ATP-gua_PtransN; 1.
Pfam graphical view of domain structure.
PROSITE PS00112; GUANIDO_KINASE; 1.
BLOCKS Q9TTK8.
Genome annotation databases
Ensembl ENSBTAG00000007502; Bos taurus. [Contig view]
GeneID 281692; -.
KEGG bta:281692; -.
Phylogenomic databases
HOVERGEN Q9TTK8; -.
Other
ProtoNet Q9TTK8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein; Transferase; Transit peptide.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    39  39     Mitochondrion (By similarity). 
CHAIN   40   416  377     Creatine kinase, ubiquitous mitochondrial. PRO_0000016589
NP_BIND   161   165  5     ATP (By similarity). 
NP_BIND   353   358  6     ATP (By similarity). 
REGION   40    64  25     Cardiolipin-binding (By similarity). 
ACT_SITE   316   316        By similarity. 
BINDING   224   224        ATP (By similarity). 
BINDING   325   325        ATP (By similarity). 
BINDING   368   368        ATP (By similarity). 
MOD_RES   153   153        Phosphotyrosine (By similarity). 
Sequence information
Length: 416 AA [This is the length of the unprocessed precursor] Molecular weight: 46897 Da [This is the MW of the unprocessed precursor] CRC64: 283F2C9F49C9C176 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGPFSRLLS ARPGLRLLAL AGAGSLAAGF LLRSEPVRAA SERRRLYPPS AEYPDLRKHN 

        70         80         90        100        110        120 
NCMASHLTPA VYARLCDKTT PTGWTLDQCI QTGVDNPGHP FIKTVGMVAG DEETYEVFAE 

       130        140        150        160        170        180 
LFDPVIQERH NGYDPRTMKH TTDLDASKIR SGYFDERYVL SSRVRTGRSI RGLSLPPACT 

       190        200        210        220        230        240 
RAERREVERV VVDALSGLKG DLAGRYYRLS EMTEAEQQQL IDDHFLFDKP VSPLLTAAGM 

       250        260        270        280        290        300 
ARDWPDARGI WHNNEKSFLI WVNEEDHTRV ISMEKGGNMK KVFERFCRGL KEVERLIQER 

       310        320        330        340        350        360 
GWEFMWNERL GYILTCPSNL GTGLRAGVHI KLPLLSKDSR FPKILENLRL QKRGTGGVDT 

       370        380        390        400        410 
AATGSVFDIS NLDRLGKSEV ELVQLVIDGV NFLIDCERRL ERGQDIRIPP PLPNKH
Q9TTK8 in FASTA format

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