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UniProtKB/Swiss-Prot entry Q9SUC0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 3HIDH_ARATH
Primary accession number Q9SUC0
Secondary accession number Q8LC25
Integrated into Swiss-Prot on January 24, 2001
Sequence was last modified on April 30, 2003 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Precursor]
Synonyms HIBADH
EC 1.1.1.31
Gene name
OrderedLocusNames: At4g20930
ORFNames: T13K14.90
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/47134; PubMed=10617198 [NCBI, ExPASy, EBI, Israel, Japan]
Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.;
"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
Nature 402:769-777(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL080282; CAB45888.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL161554; CAB79093.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY086845; AAM63893.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_567617.1; -.
UniGene At.32684
3D structure databases
ModBase Q9SUC0.
Organism-specific databases
TAIR At4g20930; -.
Gene expression databases
ArrayExpress Q9SUC0; -.
GermOnline AT4G20930; Arabidopsis thaliana.
Family and domain databases
InterPro IPR002204; 3-OH-isobutyrate_DHase-rel_CS.
IPR015815; 3hydroxyacid_DHase/Rdtase.
IPR006115; 6PGDH_NAD-bd.
IPR013328; DHase_multihelical.
IPR011548; IsoBut3OH_DH.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR22981; 3hydroxy_acid_DH; 1.
Pfam PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01692; HIBADH; 1.
PROSITE PS00895; 3_HYDROXYISOBUT_DH; 1.
BLOCKS Q9SUC0.
Genome annotation databases
GeneID 827841; -.
GenomeReviews CT486007_GR; AT4G20930.
KEGG ath:AT4G20930; -.
NMPDR fig|3702.1.peg.19926; -.
Other
ProtoNet Q9SUC0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    34  34     Mitochondrion (By similarity). 
CHAIN   35   347  313     Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial. PRO_0000007162
NP_BIND   38    67  30     NAD (By similarity). 
NP_BIND   101   102  2     NAD (By similarity). 
ACT_SITE   219   219        By similarity. 
BINDING   134   134        NAD; via amide nitrogen (By similarity). 
BINDING   294   294        NAD (By similarity). 
CONFLICT   21    21        S -> F (in Ref. 2; AAM63893). 
Sequence information
Length: 347 AA [This is the length of the unprocessed precursor] Molecular weight: 37365 Da [This is the MW of the unprocessed precursor] CRC64: 6ED2E87CC3DE191C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAIRRAQTLL CLSKFKTNFV SGSLHRFSSS SQNSNQFQNV GFIGLGNMGF RMVNNLIRAG 

        70         80         90        100        110        120 
YKVTVHDINR DVMKMFTEMG VSSRETPYEV AQDSEVVITM LPSSSHVMDV YTGTNGLLLG 

       130        140        150        160        170        180 
ENDIRPALFI DSSTIDPQTT RKISLAVSNC NLKEKRDNWE KPVMLDAPVS GGVLAAEAGT 

       190        200        210        220        230        240 
LTFMVGGPED AYLAARPILQ SMGRTSIYCG GSGNGSAAKI CNNLAMAVSM LGTSEALALG 

       250        260        270        280        290        300 
QSLGISASTL TEVLNTSSGR CWSSDAYNPV PGVMKGVPSS RDYNGGFASK LMAKDLNLAA 

       310        320        330        340 
ASAEEVGHKS PLISKAQEIY KKMCEEGHET KDFSCVFRHF YNGKDEV 

Q9SUC0 in FASTA format

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