[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1006/geno.1999.6041; PubMed=10644446 [NCBI, ExPASy, EBI, Israel, Japan] Conklin D., Gilbertson D., Taft D.W., Maurer M.F., Whitmore T.E., Smith D.L., Walker K.M., Chen L.H., Wattler S., Nehls M., Lewis K.B.; "Identification of a mammalian angiopoietin-related protein expressed specifically in liver."; Genomics 62:477-482(1999).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Liver; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Contains 1 fibrinogen C-terminal domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF162224; AAD45920.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC019491; AAH19491.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_038941.1; -.

UniGene

Mm.28341

3D structure databases

HSSP

P02671; 1FZD. [HSSP ENTRY / PDB]

ModBase

Q9R182.

Organism-specific databases

MGI

MGI:1353627; Angptl3.

Gene expression databases

ArrayExpress

Q9R182; -.

CleanEx

MM_ANGPTL3; -.

GermOnline

ENSMUSG00000028553; Mus musculus.

Ontologies

GO:0004857;	Molecular function: enzyme inhibitor activity (inferred from direct assay from UniProtKB).
GO:0005178;	Molecular function: integrin binding (inferred from sequence or structural similarity from UniProtKB).
GO:0055090;	Biological process: acylglycerol homeostasis (inferred from mutant phenotype from UniProtKB).
GO:0048844;	Biological process: artery morphogenesis (inferred from mutant phenotype from UniProtKB).
GO:0007160;	Biological process: cell-matrix adhesion (inferred from sequence or structural similarity from UniProtKB).
GO:0042632;	Biological process: cholesterol homeostasis (inferred from mutant phenotype from UniProtKB).
GO:0010519;	Biological process: negative regulation of phospholipase activity (inferred from mutant phenotype from UniProtKB).
GO:0055091;	Biological process: phospholipid homeostasis (inferred from mutant phenotype from UniProtKB).
GO:0045766;	Biological process: positive regulation of angiogenesis (inferred from sequence or structural similarity from UniProtKB).
GO:0030335;	Biological process: positive regulation of cell migration (inferred from sequence or structural similarity from UniProtKB).
GO:0045834;	Biological process: positive regulation of lipid metabolic process (non-traceable author statement from UniProtKB).
GO:0006641;	Biological process: triacylglycerol metabolic process (non-traceable author statement from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR002181; Fibrinogen_a/b/g_C.
IPR014716; Fibrinogen_a/b/g_C_1.
Graphical view of domain structure.

Gene3D

G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.

Pfam

PF00147; Fibrinogen_C; 1.
Pfam graphical view of domain structure.

SMART

SM00186; FBG; 1.
SMART graphical view of domain structure.

PROSITE

PS00514; FIBRIN_AG_C_DOMAIN; FALSE_NEG.

BLOCKS

Q9R182.

Genome annotation databases

Ensembl

ENSMUSG00000028553; Mus musculus. [Contig view]

GeneID

30924; -.

KEGG

mmu:30924; -.

Phylogenomic databases

HOGENOM

Q9R182; -.

HOVERGEN

Q9R182; -.

Other

SOURCE

Angptl3; Mus musculus.

ProtoNet

Q9R182.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Coiled coil; Glycoprotein; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 16`	`16`	`Potential.`
`CHAIN`	`17 455`	`439`	`Angiopoietin-related protein 3.`	`PRO_0000009123`
`DOMAIN`	`241 455`	`215`	`Fibrinogen C-terminal.`
`COILED`	`85 206`	`122`	`Potential.`
`CARBOHYD`	`115 115`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`232 232`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`296 296`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`357 357`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`246 274`		`By similarity.`
`DISULFID`	`394 408`		`By similarity.`

Sequence information

Length: 455 AA [This is the length of the unprocessed precursor]

Molecular weight: 52543 Da [This is the MW of the unprocessed precursor]

CRC64: 31609D3700D3F33D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHTIKLFLFV VPLVIASRVD PDLSSFDSAP SEPKSRFAML DDVKILANGL LQLGHGLKDF 

        70         80         90        100        110        120 
VHKTKGQIND IFQKLNIFDQ SFYDLSLRTN EIKEEEKELR RTTSTLQVKN EEVKNMSVEL 

       130        140        150        160        170        180 
NSKLESLLEE KTALQHKVRA LEEQLTNLIL SPAGAQEHPE VTSLKSFVEQ QDNSIRELLQ 

       190        200        210        220        230        240 
SVEEQYKQLS QQHMQIKEIE KQLRKTGIQE PSENSLSSKS RAPRTTPPLQ LNETENTEQD 

       250        260        270        280        290        300 
DLPADCSAVY NRGEHTSGVY TIKPRNSQGF NVYCDTQSGS PWTLIQHRKD GSQDFNETWE 

       310        320        330        340        350        360 
NYEKGFGRLD GEFWLGLEKI YAIVQQSNYI LRLELQDWKD SKHYVEYSFH LGSHETNYTL 

       370        380        390        400        410        420 
HVAEIAGNIP GALPEHTDLM FSTWNHRAKG QLYCPESYSG GWWWNDICGE NNLNGKYNKP 

       430        440        450 
RTKSRPERRR GIYWRPQSRK LYAIKSSKMM LQPTT

Q9R182 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools