[1]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Lung, and Testis;
DOI=10.1016/S0014-5793(99)00966-7; PubMed=10456327 [NCBI, ExPASy, EBI, Israel, Japan]
Shimizu K.,
Tani M.,
Watanabe H.,
Nagamachi Y.,
Niinaka Y.,
Shiroishi T.,
Ohwada S.,
Raz A.,
Yokota J.;
"The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein.";
FEBS Lett. 456:295-300(1999).
|
[2]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=FVB/N;
TISSUE=Colon, and Mammary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[3]
|
ROLE IN METASTASIS.
DOI=10.1023/A:1022594503657; PubMed=12650607 [NCBI, ExPASy, EBI, Israel, Japan]
Onishi Y.,
Tsukada K.,
Yokota J.,
Raz A.;
"Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation.";
Clin. Exp. Metastasis 20:51-58(2003).
|
[4]
|
INTERACTION WITH NGLY1; PSMC1; SAKS1; RAD23B AND VCP.
DOI=10.1073/pnas.0602747103; PubMed=16709668 [NCBI, ExPASy, EBI, Israel, Japan]
Li G.,
Zhao G.,
Zhou X.,
Schindelin H.,
Lennarz W.J.;
"The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor.";
Proc. Natl. Acad. Sci. U.S.A. 103:8348-8353(2006).
|
[5]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-542, AND MASS SPECTROMETRY.
TISSUE=Brain cortex;
DOI=10.1074/mcp.M600046-MCP200; PubMed=17114649 [NCBI, ExPASy, EBI, Israel, Japan]
Munton R.P.,
Tweedie-Cullen R.,
Livingstone-Zatchej M.,
Weinandy F.,
Waidelich M.,
Longo D.,
Gehrig P.,
Potthast F.,
Rutishauser D.,
Gerrits B.,
Panse C.,
Schlapbach R.,
Mansuy I.M.;
"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.";
Mol. Cell. Proteomics 6:283-293(2007).
|
|
- FUNCTION: Specific receptor for the autocrine motility factor. Possesses ubiquitin ligase activity and can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems.
- CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
- SUBUNIT: Interacts with UBE2G2/UBC7 through a region distinct from the RING finger. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B.
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
|
| Name | 2 |
| Isoform ID | Q9R049-2 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_008224. |
|
|
- TISSUE SPECIFICITY: Expressed in heart, brain, liver, lung, skeletal muscle, kidney and testis. Not detected in spleen.
- SIMILARITY: Contains 1 CUE domain.
- SIMILARITY: Contains 1 RING-type zinc finger.
|
ExPASy Home page
SIB Switzerland
