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UniProtKB/Swiss-Prot entry Q9QZU9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UB2L6_MOUSE
Primary accession number Q9QZU9
Secondary accession numbers Q922F1 Q9CQN0
Integrated into Swiss-Prot on April 26, 2004
Sequence was last modified on April 26, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 63)
Name and origin of the protein
Protein name Ubiquitin/ISG15-conjugating enzyme E2 L6
Synonyms EC 6.3.2.19
Ubiquitin-protein ligase L6
Ubiquitin carrier protein L6
UbcM8
Gene name
Name: Ube2l6
Synonyms: Ubce8
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Cook G., Lawshe A., MacArthur C.A.;
"Progression from mammary hyperplasia to adenocarcinoma in MMTV-FGF8b transgenic mice is associated with altered expression of CD63, IGFBP7/mac25, alpha-synuclein, and UbcM8.";
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Embryo, and Embryonic liver;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF159230; AAD55978.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK013452; BAB28861.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK010942; BAB27282.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008238; AAH08238.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_064333.1; -.
UniGene Mm.38261
3D structure databases
HSSP P51966; 1C4Z. [HSSP ENTRY / PDB]
SMR Q9QZU9; 2-151.
ModBase Q9QZU9.
Organism-specific databases
MGI MGI:1914500; Ube2l6.
Gene expression databases
CleanEx MM_UBE2L6; -.
GermOnline ENSMUSG00000027078; Mus musculus.
Ontologies
GO
GO:0042296; Molecular function: ISG15 ligase activity (inferred from direct assay from MGI).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from MGI).
GO:0032020; Biological process: ISG15-protein conjugation (inferred from direct assay from MGI).
GO:0019941; Biological process: modification-dependent protein catabolic process (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.
Gene3D G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
PANTHER PTHR11621; UBQ-conjugat_E2; 1.
Pfam PF00179; UQ_con; 1.
Pfam graphical view of domain structure.
ProDom PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00212; UBCc; 1.
SMART graphical view of domain structure.
PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9QZU9.
Genome annotation databases
Ensembl ENSMUSG00000027078; Mus musculus. [Contig view]
GeneID 56791; -.
KEGG mmu:56791; -.
NMPDR fig|10090.3.peg.6261; -.
Phylogenomic databases
HOVERGEN Q9QZU9; -.
Other
SOURCE Ube2l6; Mus musculus.
ProtoNet Q9QZU9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Ligase; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   152  152     Ubiquitin/ISG15-conjugating enzyme E2 L6. PRO_0000082479
ACT_SITE   85    85        Glycyl thioester intermediate (By similarity). 
CONFLICT   28    28        D -> Y (in Ref. 1; AAD55978). 
CONFLICT   62    62        F -> L (in Ref. 3; AAH08238). 
Sequence information
Length: 152 AA [This is the length of the unprocessed precursor] Molecular weight: 17710 Da [This is the MW of the unprocessed precursor] CRC64: 9153222191DE1E25 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MASKRVAKEL ESLSKELPPY LRQLSSDDAN VLVWHMLLLP DQLPYGLKAF QVRIDFPREY 

        70         80         90        100        110        120 
PFKPPTLRFT TKIYHPNVRE DGLVCLPLIS NENWKPYTKP YQVLEALNVL VSKPNLEEPV 

       130        140        150 
RLELADLLTQ NPEMFRKKAE EFTLKFGVDR PS 

Q9QZU9 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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