ID   MPP4_RAT                Reviewed;         441 AA.
AC   Q9QYH1; Q9QYG9; Q9QYH0;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   22-JUL-2008, entry version 46.
DE   RecName: Full=MAGUK p55 subfamily member 4;
DE   AltName: Full=Discs large homolog 6;
DE            Short=rDLG6;
GN   Name=Mpp4; Synonyms=Dlg6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY,
RP   AND INTERACTION WITH GRIA2.
RC   STRAIN=Sprague-Dawley; TISSUE=Cerebellum;
RX   MEDLINE=20025366; PubMed=10558890; DOI=10.1006/bbrc.1999.1723;
RA   Inagaki H., Maeda S., Lin K.H., Shimizu N., Saito T.;
RT   "rDLG6: a novel homolog of Drosophila DLG expressed in rat brain.";
RL   Biochem. Biophys. Res. Commun. 265:462-468(1999).
CC   -!- FUNCTION: May play a role in retinal photoreceptors development
CC       (By similarity).
CC   -!- SUBUNIT: Interacts with MPDZ (By similarity). May interact with
CC       GRIA2. Forms a complex with CRB1 and MPP5 (By similarity).
CC   -!- INTERACTION:
CC       Q6P7B6:Efnb1; NbExp=1; IntAct=EBI-937554, EBI-937609;
CC       P19491:Gria2; NbExp=1; IntAct=EBI-937554, EBI-77718;
CC       P35407:Il8rb; NbExp=1; IntAct=EBI-937554, EBI-937591;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Localized at photoreceptor
CC       synaptic terminals in retina (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=Alpha;
CC         IsoId=Q9QYH1-1; Sequence=Displayed;
CC       Name=2; Synonyms=Beta;
CC         IsoId=Q9QYH1-2; Sequence=VSP_014001;
CC       Name=3; Synonyms=Gamma;
CC         IsoId=Q9QYH1-3; Sequence=VSP_014000;
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain and detected in
CC       lung, and bone (at protein level). Also expressed in intestine and
CC       spleen.
CC   -!- SIMILARITY: Belongs to the MAGUK family.
CC   -!- SIMILARITY: Contains 1 guanylate kinase-like domain.
CC   -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
CC   -!- SIMILARITY: Contains 1 SH3 domain.
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DR   EMBL; AB030499; BAA88229.1; -; mRNA.
DR   EMBL; AB030500; BAA88230.1; -; mRNA.
DR   EMBL; AB030501; BAA88231.1; -; mRNA.
DR   RefSeq; NP_067088.2; -.
DR   UniGene; Rn.163075; -.
DR   HSSP; Q64010; 1M3B.
DR   IntAct; Q9QYH1; -.
DR   Ensembl; ENSRNOG00000010486; Rattus norvegicus.
DR   GeneID; 58808; -.
DR   KEGG; rno:58808; -.
DR   RGD; 620016; Mpp4.
DR   HOVERGEN; Q9QYH1; -.
DR   ArrayExpress; Q9QYH1; -.
DR   GermOnline; ENSRNOG00000010486; Rattus norvegicus.
DR   GO; GO:0005102; F:receptor binding; IPI:UniProtKB.
DR   InterPro; IPR008144; Guanylate_kin.
DR   InterPro; IPR008145; Guanylt/Ca.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR001452; SH3.
DR   InterPro; IPR011511; SH3_2.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   ProDom; PD000066; SH3; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00326; SH3; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; SH3 domain.
FT   CHAIN         1    441       MAGUK p55 subfamily member 4.
FT                                /FTId=PRO_0000094579.
FT   DOMAIN        1     84       PDZ.
FT   DOMAIN       91    161       SH3.
FT   DOMAIN      232    421       Guanylate kinase-like.
FT   COILED      373    430       Potential.
FT   VAR_SEQ     181    441       Missing (in isoform 3).
FT                                /FTId=VSP_014000.
FT   VAR_SEQ     334    351       Missing (in isoform 2).
FT                                /FTId=VSP_014001.
SQ   SEQUENCE   441 AA;  50052 MW;  EB5F0711B4AC7CD6 CRC64;
     MRTVCLVKNQ QPLGATIKRH EITGDILVAR VIHGGLVERN GLLYAGDKLV EVNGVPVEGL
     DPEQVIHILA MSCGTIMFKV IPVSAPPVSS QTTVYVRAMI DYWPQEDPDI PCMDAGLPFL
     KGDILQIVDQ SDALWWQARK ISDIAICAGL IPSNHLLKRK QREFWWSQPY QPHTCLKSTR
     SKEEFVGDGQ QFFIAGFRQQ HANMRCTCSC YSAVGAPYEE VVRYQRQPAD KHRLIVLVGP
     SGVGVNELRR QLIGCNPSCF QSAVPHTTRS PKSYEMDGRE YHYVSRETFE SLMYGHRMLE
     FGEYKGHLYG TSVNAVLAVL DEGKICVMDL EPQDIQLART RELKPYVIFI KPPSMSSMRH
     SRRNAKIITD YFVDMKFKDE DLQEMEELAQ KMESQFGQFF DHVIVNDNLQ DARAQLLSAI
     QKAEEELQWV PEAWVSPGAE S
//