Erythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JVI.77.24.13335-13347.2003; PubMed=14645589 [NCBI, ExPASy, EBI, Israel, Japan]
Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G.;
"Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus.";
J. Virol. 77:13335-13347(2003).

Comments

FUNCTION: Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites (By similarity).
CATALYTIC ACTIVITY: NTP + H₂O = NDP + phosphate.
SUBUNIT: Monomer.
SIMILARITY: Belongs to the helicase family. NPH I subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY386371; AAR07444.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_938343.1; -.

3D structure databases

ModBase

Q9QB93.

Family and domain databases

InterPro

IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR013676; NPHI_C.
IPR000330; SNF2_N.
Graphical view of domain structure.

Pfam

PF00271; Helicase_C; 1.
PF08469; NPHI_C; 1.
PF00176; SNF2_N; 1.
Pfam graphical view of domain structure.

SMART

SM00487; DEXDc; 1.
SMART graphical view of domain structure.

PROSITE

PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q9QB93.

Genome annotation databases

GeneID

2943701; -.

Other

ProtoNet

Q9QB93.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Hydrolase; Nucleotide-binding; Transcription.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 631`	`631`	`Nucleoside triphosphatase I.`	`PRO_0000099098`
`DOMAIN`	`42 204`	`163`	`Helicase ATP-binding.`
`DOMAIN`	`367 536`	`170`	`Helicase C-terminal.`
`NP_BIND`	`55 62`	`8`	`ATP (By similarity).`
`MOTIF`	`141 144`	`4`	`DEXH box.`

Sequence information

Length: 631 AA [This is the length of the unprocessed precursor]

Molecular weight: 72579 Da [This is the MW of the unprocessed precursor]

CRC64: 06561CA08C729EFF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSRQHAAYID YALNRMKKMP IEMLGSDTIT LKPYQHFVAK VFLGLDTMHS ILLFHDTGVG 

        70         80         90        100        110        120 
KTITTVFILK HLKDIYTNWT ILLLVKKALV EDPWMNTILK YSPEIIKNCI FINYDDKNFH 

       130        140        150        160        170        180 
NKFFTNIKTI SSRSRVCVVL DECHNFISKS LIKEDGKQRP TKSVYNYLSK NISLNNNKMI 

       190        200        210        220        230        240 
CLSATPIVNN VREFTMIVNL LRPKIIQFQS LFENKNLVNE KELIDKLGGI CSYIVNDEFS 

       250        260        270        280        290        300 
IFDDVEGSQS FAKKTVYMHY VNMTKQQEII YQKAKIAEIK SGIASFRIYR RMAATFSFDS 

       310        320        330        340        350        360 
FPDKKKKTID EITLELGALY KDFVNYVNKK SFSNNAIKLF KSGKGLTGDS NPLDISLLSE 

       370        380        390        400        410        420 
LRQKSCKFTE VCLKILASPG KCLVFEPFIN QSGIEVLLVY FSVFCITSVE FSSRTKDTRI 

       430        440        450        460        470        480 
KNVFEFNKES NTNGEQIKVC VFSISGGEGI SFFSINDIFI LDMTWNEASL KQIVGRAIRL 

       490        500        510        520        530        540 
NSHANTPPNR RYVNVYFIIA RLSSGEPTVD EDLINIIKTK SKEFFQLFKV FKESSIEWIY 

       550        560        570        580        590        600 
KNKKDFYPIN DESGWRALTS RVVDVNVKSK RTVQLAQGQN IWFSNSSRMV TIHKGFKTSD 

       610        620        630 
GKIFDVDGNF IQNMPINPII KIHNDKLVYI I

Q9QB93 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools