[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1006/viro.1999.0002; PubMed=10562495 [NCBI, ExPASy, EBI, Israel, Japan] Willer D.O., McFadden G., Evans D.H.; "The complete genome sequence of shope (Rabbit) fibroma virus."; Virology 264:319-343(1999).

Comments

FUNCTION: Essential for viral replication. Plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Acts as NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for propagation of viral particles (By similarity).
CATALYTIC ACTIVITY: NTP + H₂O = NDP + phosphate.
SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF170722; AAF17926.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_051933.1; -.

3D structure databases

ModBase

Q9Q927.

Family and domain databases

InterPro

IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR002464; DNA/RNA_helicase_DEAH_CS.
IPR014021; Helicase_SF1/SF2_ATP-bd.
Graphical view of domain structure.

Pfam

PF00271; Helicase_C; 1.
Pfam graphical view of domain structure.

SMART

SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.

PROSITE

PS00690; DEAH_ATP_HELICASE; 1.
PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q9Q927.

Genome annotation databases

GeneID

1486887; -.

Other

ProtoNet

Q9Q927.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Transcription.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 678`	`678`	`Nucleoside triphosphatase II.`	`PRO_0000055191`
`DOMAIN`	`175 351`	`177`	`Helicase ATP-binding.`
`DOMAIN`	`371 546`	`176`	`Helicase C-terminal.`
`NP_BIND`	`188 195`	`8`	`ATP (By similarity).`
`MOTIF`	`300 303`	`4`	`DEXH box.`

Sequence information

Length: 678 AA [This is the length of the unprocessed precursor]

Molecular weight: 78243 Da [This is the MW of the unprocessed precursor]

CRC64: FDF8FDD5E5C58B1E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MENHLPNIFY FPNCVTTFPY RYTQKELDDM KPDERERFKY ATFPIIKHRW SHAYVVKDNH 

        70         80         90        100        110        120 
VFKLNVETSK RLRRATPPTL SVPVSMNTML REYITQDGTK ISFECYSYLT CKKATSLHDL 

       130        140        150        160        170        180 
DDNAIRGLVE GGNRLQLFTN SVGSVKDTVG IFGNPNPFMK VPLKSLHPSM QCKIFESWIH 

       190        200        210        220        230        240 
HVPVVLTGDT GVGKTSQVPK LLLWFNYLFG GFVNLSTITF DVQEKPIVLS LPRVALVKLH 

       250        260        270        280        290        300 
SETLLTSLGF NEIHKSPVSL KFGNMQEQFV NTRFRRYGIV FSTHKITLNT LFNYSTVILD 

       310        320        330        340        350        360 
EVHEHDQTGD IIIAVCRKYI RKLDSLFLMT ATLEDDRQRI EEFFTESVFV HIPGGTLFSI 

       370        380        390        400        410        420 
SEAYVKNSND SLNKFMYIEE EKRNLVNAIK TYTPPKQSSG IVFVSTVSQC DVYKQYLSER 

       430        440        450        460        470        480 
LPYKFYIIHG KIQNINDLLS DIYDNEGVSI IISTPYLESS VTVQNATHVY DTGRVYIPSP 

       490        500        510        520        530        540 
YGGREVFISK SMRDQRKGRV GRVKPGMYIY FYDVSELRPI KRIDFEFLHN YVLYSKVFDL 

       550        560        570        580        590        600 
QLPEDLFVKP TNMTRLRDVI EYIRSFNISD GVWTRLLSSY YIHILEYAKV YARGGQSAAA 

       610        620        630        640        650        660 
LDSFERTGNL TDDALDAIKS LNMRAKIISH RKASTHTYAL MCRLLFGVYA GKTFIAYHKR 

       670 
PLTGYITMIT EHSFIPEY

Q9Q927 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools