ID   NTP1_MYXVL              Reviewed;         632 AA.
AC   Q9Q8L4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-NOV-2008, entry version 46.
DE   RecName: Full=Nucleoside triphosphatase I;
DE            EC=3.6.1.15;
DE   AltName: Full=Nucleoside triphosphate phosphohydrolase I;
DE            Short=NPH I;
DE   AltName: Full=M86L protein;
GN   Name=NPH1; OrderedLocusNames=m086L;
OS   Myxoma virus (strain Lausanne) (MYXV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Leporipoxvirus.
OX   NCBI_TaxID=31530;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=20032073; PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA   Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X.,
RA   Macaulay C., Willer D.O., Evans D.H., McFadden G.;
RT   "The complete DNA sequence of myxoma virus.";
RL   Virology 264:298-318(1999).
CC   -!- FUNCTION: Serves two roles in transcription; it acts in concert
CC       with viral termination factor/capping enzyme to catalyze release
CC       of UUUUUNU-containing nascent RNA from the elongation complex, and
CC       it acts by itself as a polymerase elongation factor to facilitate
CC       readthrough of intrinsic pause sites (By similarity).
CC   -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the helicase family. NPH I subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
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DR   EMBL; AF170726; AAF14974.1; -; Genomic_DNA.
DR   RefSeq; NP_051800.1; -.
DR   GeneID; 932112; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR014001; DEAD-like_N.
DR   InterPro; IPR001650; DNA/RNA_helicase_C.
DR   InterPro; IPR014021; Helicase_SF1/SF2_ATP-bd.
DR   InterPro; IPR013676; NPHI_C.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF08469; NPHI_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Hydrolase; Nucleotide-binding; Transcription.
FT   CHAIN         1    632       Nucleoside triphosphatase I.
FT                                /FTId=PRO_0000099095.
FT   DOMAIN       42    204       Helicase ATP-binding.
FT   DOMAIN      367    532       Helicase C-terminal.
FT   NP_BIND      55     62       ATP (By similarity).
FT   MOTIF       141    144       DEXH box.
SQ   SEQUENCE   632 AA;  72623 MW;  9EED5BF143FAC0CD CRC64;
     MSVYHAAYID YALRVTENMT DVMTGSETVT LKSYQHFVSR VFLGLDKMHS LLLFHETGVG
     KTITTVFILK HLKDVYTNWI IILLVKKALV EDPWTYAITK YAPEILKDCI FITYDDKNFH
     NKFFTNIKTI SSRTRLCIII DECHNFISKS IIKEDGKQRP TKSVYNYLSK NVALHHHKLI
     CLSATPIVNS VKEFVMLVNL LRPKILSNVS LFENKRLVNE SELINKLGAI CSYIVTNEFS
     IFDDVAGSSA FARKTVYFQY VNMTQKQEQV YQKAKLAELK AGISSFRIYR RMAATFTFDA
     FLDKTDKTPE EVANEQITLY KDFETFIKTK KFSEHALSQF KRGQSLGGTS SADDISFLNE
     LRERSCKFTD VCLRILASPG KCLVFEPFVN QSGINILLLY FSAFNISYIE FSSRTKNTRV
     QSVAEFNKRE NTDGDLIKTC VFSLSGGEGI SFFSINDIFI LDMTWNEASL RQIIGRAIRL
     NSHVLTPEHR RYVNVHFIVA RLSNGDATVD EDLLDIIRTK SKEFTQLFKV FKHTSIEWIY
     EHQTDFSPVD NESGWSALIS RSIDENPTTK RVPHVVKGQN IWYSHSNRLI AVYKGFKTDD
     GRLFDSDGNF IQTIQDNPVI KIHNDKLVYV LD
//