FUNCTION: Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites (By similarity).
CATALYTIC ACTIVITY: NTP + H₂O = NDP + phosphate.
SUBUNIT: Monomer.
SIMILARITY: Belongs to the helicase family. NPH I subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

Copyright

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Cross-references

Sequence databases

EMBL

AF170726; AAF14974.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_051800.1; -.

3D structure databases

ModBase

Q9Q8L4.

Ontologies

GO:0017111;	Molecular function: nucleoside-triphosphatase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR013676; NPHI_C.
IPR000330; SNF2_N.
Graphical view of domain structure.

Pfam

PF00271; Helicase_C; 1.
PF08469; NPHI_C; 1.
PF00176; SNF2_N; 1.
Pfam graphical view of domain structure.

SMART

SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.

PROSITE

PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q9Q8L4.

Genome annotation databases

GeneID

932112; -.

Other

ProtoNet

Q9Q8L4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Hydrolase; Nucleotide-binding; Transcription.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 632`	`632`	`Nucleoside triphosphatase I.`	`PRO_0000099095`
`DOMAIN`	`42 204`	`163`	`Helicase ATP-binding.`
`DOMAIN`	`367 532`	`166`	`Helicase C-terminal.`
`NP_BIND`	`55 62`	`8`	`ATP (By similarity).`
`MOTIF`	`141 144`	`4`	`DEXH box.`

Sequence information

Length: 632 AA [This is the length of the unprocessed precursor]

Molecular weight: 72623 Da [This is the MW of the unprocessed precursor]

CRC64: 9EED5BF143FAC0CD [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVYHAAYID YALRVTENMT DVMTGSETVT LKSYQHFVSR VFLGLDKMHS LLLFHETGVG 

        70         80         90        100        110        120 
KTITTVFILK HLKDVYTNWI IILLVKKALV EDPWTYAITK YAPEILKDCI FITYDDKNFH 

       130        140        150        160        170        180 
NKFFTNIKTI SSRTRLCIII DECHNFISKS IIKEDGKQRP TKSVYNYLSK NVALHHHKLI 

       190        200        210        220        230        240 
CLSATPIVNS VKEFVMLVNL LRPKILSNVS LFENKRLVNE SELINKLGAI CSYIVTNEFS 

       250        260        270        280        290        300 
IFDDVAGSSA FARKTVYFQY VNMTQKQEQV YQKAKLAELK AGISSFRIYR RMAATFTFDA 

       310        320        330        340        350        360 
FLDKTDKTPE EVANEQITLY KDFETFIKTK KFSEHALSQF KRGQSLGGTS SADDISFLNE 

       370        380        390        400        410        420 
LRERSCKFTD VCLRILASPG KCLVFEPFVN QSGINILLLY FSAFNISYIE FSSRTKNTRV 

       430        440        450        460        470        480 
QSVAEFNKRE NTDGDLIKTC VFSLSGGEGI SFFSINDIFI LDMTWNEASL RQIIGRAIRL 

       490        500        510        520        530        540 
NSHVLTPEHR RYVNVHFIVA RLSNGDATVD EDLLDIIRTK SKEFTQLFKV FKHTSIEWIY 

       550        560        570        580        590        600 
EHQTDFSPVD NESGWSALIS RSIDENPTTK RVPHVVKGQN IWYSHSNRLI AVYKGFKTDD 

       610        620        630 
GRLFDSDGNF IQTIQDNPVI KIHNDKLVYV LD

Q9Q8L4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools