[1]	NUCLEOTIDE SEQUENCE [GENOMIC RNA]. DOI=10.1006/viro.2000.0263; PubMed=10772993 [NCBI, ExPASy, EBI, Israel, Japan] Takimoto T., Taylor G.L., Crennell S.J., Scroggs R.A., Portner A.; "Crystallization of Newcastle disease virus hemagglutinin-neuraminidase glycoprotein."; Virology 270:208-214(2000).
[2]	X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 124-577. DOI=10.1038/81002; PubMed=11062565 [NCBI, ExPASy, EBI, Israel, Japan] Crennell S., Takimoto T., Portner A., Taylor G.; "Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase."; Nat. Struct. Biol. 7:1068-1074(2000).

Comments

FUNCTION: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
FUNCTION: Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
SUBCELLULAR LOCATION: Virion membrane; Single-pass type II membrane protein (Potential). Cell membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF212323; AAF19984.1; -; Genomic_RNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

PDB

1E8T; X-ray; 2.50 A; A/B=124-577.	[ExPASy / RCSB / EBI]
1E8U; X-ray; 2.00 A; A/B=124-577.	[ExPASy / RCSB / EBI]
1E8V; X-ray; 2.00 A; A/B=124-577.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

1E8T; -.
1E8U; -.
1E8V; -.

ModBase

Q9Q2W5.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0019031;	Cellular component: viral envelope (inferred from electronic annotation from InterPro).
GO:0055036;	Cellular component: virion membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004308;	Molecular function: exo-alpha-sialidase activity (inferred from electronic annotation from InterPro).
GO:0046789;	Molecular function: host cell surface receptor binding (inferred from electronic annotation from InterPro).
GO:0019058;	Biological process: viral infectious cycle (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000665; Hemagglutn-neuramid_glycoprot.
IPR016285; Hemagglutn-neuramid_paramyxo.
Graphical view of domain structure.

Pfam

PF00423; HN; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001072; Hemagglut-neuramid_paramyxoV; 1.

Other

Q9Q2W5; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Cell membrane; Envelope protein; Glycoprotein; Hemagglutinin; Hydrolase; Membrane; Signal-anchor; Transmembrane; Virion.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 577`	`577`	`Hemagglutinin-neuraminidase.`	`PRO_0000142614`
`TOPO_DOM`	`1 22`	`22`	`Cytoplasmic (Potential).`
`TRANSMEM`	`23 45`	`23`	`Potential.`
`TOPO_DOM`	`46 571`	`526`	`Extracellular (Potential).`
`CARBOHYD`	`119 119`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`144 144`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`341 341`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`433 433`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`481 481`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`538 538`		`N-linked (GlcNAc...) (Potential).`
`TURN`	`130 134`	`5`
`STRAND`	`136 138`	`3`
`STRAND`	`144 146`	`3`
`HELIX`	`148 150`	`3`
`STRAND`	`151 153`	`3`
`STRAND`	`172 180`	`9`
`STRAND`	`185 195`	`11`
`STRAND`	`202 213`	`12`
`STRAND`	`219 229`	`11`
`STRAND`	`235 243`	`9`
`STRAND`	`246 253`	`8`
`HELIX`	`258 263`	`6`
`STRAND`	`264 266`	`3`
`STRAND`	`269 276`	`8`
`STRAND`	`281 285`	`5`
`HELIX`	`288 291`	`4`
`TURN`	`292 294`	`3`
`STRAND`	`295 300`	`6`
`STRAND`	`306 308`	`3`
`STRAND`	`311 320`	`10`
`HELIX`	`325 330`	`6`
`HELIX`	`348 357`	`10`
`HELIX`	`362 364`	`3`
`STRAND`	`368 377`	`10`
`STRAND`	`379 381`	`3`
`STRAND`	`387 389`	`3`
`TURN`	`393 395`	`3`
`STRAND`	`402 407`	`6`
`STRAND`	`410 415`	`6`
`STRAND`	`423 432`	`10`
`STRAND`	`435 438`	`4`
`STRAND`	`442 444`	`3`
`STRAND`	`473 478`	`6`
`STRAND`	`484 492`	`9`
`STRAND`	`495 499`	`5`
`STRAND`	`501 506`	`6`
`STRAND`	`523 534`	`12`
`TURN`	`535 538`	`4`
`STRAND`	`539 549`	`11`
`HELIX`	`551 553`	`3`
`STRAND`	`557 567`	`11`

Sequence information

Length: 577 AA [This is the length of the unprocessed precursor]

Molecular weight: 63111 Da [This is the MW of the unprocessed precursor]

CRC64: 6A1F03C8DD3F7753 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDRAVSQVAL ENDEREAKNT WRLIFRIAIL LLTVVTLATS VASLVYSMGA STPSDLVGIP 

        70         80         90        100        110        120 
TRISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE TTIMNAITSL SYQINGAANN 

       130        140        150        160        170        180 
SGWGAPIHDP DFIGGIGKEL IVDNASDVTS FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM 

       190        200        210        220        230        240 
SATHYCYTHN VILSGCRDHS HSHQYLALGV LRTTATGRIF FSTLRSISLD DTQNRKSCSV 

       250        260        270        280        290        300 
SATPLGCDML CSKVTETEEE DYNSAVPTLM AHGRLGFDGQ YHEKDLDVTT LFEDWVANYP 

       310        320        330        340        350        360 
GVGGGSFIDG RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY QIRMAKSSYK 

       370        380        390        400        410        420 
PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA EGRILTVGTS HFLYQRGSSY 

       430        440        450        460        470        480 
FSPALLYPMT VSNKTATLHS PYTFNAFTRP GSIPCQASAR CPNSCVTGVY TDPYPLIFYR 

       490        500        510        520        530        540 
NHTLRGVFGT MLDSEQARLN PASAVFDSTS RSRITRVSSS STKAAYTTST CFKVVKTNKT 

       550        560        570 
YCLSIAEISN TLFGEFRIVP LLVEILKNDG VREARSG

Q9Q2W5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools