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UniProtKB/Swiss-Prot entry Q9PVK5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_DANRE
Primary accession number Q9PVK5
Secondary accession numbers None
Integrated into Swiss-Prot on November 16, 2001
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
Gene name
Name: ldha
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Tsoi S.C.-M., Li J.Y., Mannen H., Li S.S.-L.;
"Molecular evolution of vertebrate lactate dehydrogenase isozymes by gene duplication.";
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF067201; AAF02212.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067188; AAH67188.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_571321.1; -.
UniGene Dr.4212
3D structure databases
HSSP P00338; 1I10. [HSSP ENTRY / PDB]
SMR Q9PVK5; 2-333.
ModBase Q9PVK5.
Organism-specific databases
ZFIN ZDB-GENE-991026-5; ldha.
Ontologies
GO
GO:0001666; Biological process: response to hypoxia (inferred from direct assay from ZFIN).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q9PVK5.
Genome annotation databases
Ensembl ENSDARG00000040856; Danio rerio. [Contig view]
GeneID 30496; -.
KEGG dre:30496; -.
Phylogenomic databases
HOGENOM Q9PVK5; -.
HOVERGEN Q9PVK5; -.
Other
ProtoNet Q9PVK5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   333  332     L-lactate dehydrogenase A chain. PRO_0000168429
NP_BIND   30    58  29     NAD (By similarity). 
ACT_SITE   194   194        Proton acceptor (By similarity). 
BINDING   100   100        NAD (By similarity). 
BINDING   107   107        Substrate (By similarity). 
BINDING   139   139        NAD or substrate (By similarity). 
BINDING   170   170        Substrate (By similarity). 
BINDING   249   249        Substrate (By similarity). 
Sequence information
Length: 333 AA [This is the length of the unprocessed precursor] Molecular weight: 36246 Da [This is the MW of the unprocessed precursor] CRC64: B5A040A6DDC014BC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MASTKEKLIA HVSKEQPAGP TNKVTVVGVG MVGMAAAVSI LLKDLTDELA LVDVMEDKLK 

        70         80         90        100        110        120 
GEAMDLQHGS LFLKTHKIVA DKDYSVTANS KVVVVTAGAR QQEGESRLNL VQRNVNIFKF 

       130        140        150        160        170        180 
IIPNIIKYSP NCILLVVSNP VDILTYVAWK LSGLPRNRVI GSGTNLDSAR FRYLMGEKLG 

       190        200        210        220        230        240 
IHPSSCHGWV VGEHGDSSVP VWSGVNVAGV SLQALNPDLG TDKDKEDWKS VHKMVVDSAY 

       250        260        270        280        290        300 
EVIKLKGYTS WAIGMSVADL CESILKNMHK CHPVSTLVKG MHGVNEEVFL SVPCILGNNG 

       310        320        330 
LTDVVHMTLK PEEEKQLVKS AETLWGVQKE LTL
Q9PVK5 in FASTA format

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