ID   G6PD_CHLMU              Reviewed;         507 AA.
AC   Q9PKK8;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-NOV-2008, entry version 51.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=zwf; OrderedLocusNames=TC_0457;
OS   Chlamydia muridarum.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia.
OX   NCBI_TaxID=83560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA   White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA   Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA   Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA   McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT   pneumoniae AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; AE002160; AAF73556.1; -; Genomic_DNA.
DR   RefSeq; NP_296834.1; -.
DR   HSSP; P11413; 1QKI.
DR   GeneID; 1245812; -.
DR   GenomeReviews; AE002160_GR; TC_0457.
DR   KEGG; cmu:TC0457; -.
DR   TIGR; TC_0457; -.
DR   HOGENOM; Q9PKK8; -.
DR   BioCyc; CMUR243161:TC_0457-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001282; Glc-6-P_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    507       Glucose-6-phosphate 1-dehydrogenase.
FT                                /FTId=PRO_0000068115.
FT   ACT_SITE    260    260       Proton acceptor (By similarity).
FT   BINDING      25     25       NADP (By similarity).
FT   BINDING      57     57       NADP (By similarity).
FT   BINDING     198    198       Substrate (By similarity).
FT   BINDING     202    202       Substrate (By similarity).
SQ   SEQUENCE   507 AA;  58548 MW;  C66F3FE1562391A6 CRC64;
     MEEIKEMGPT LPACPPCVMV IFGATGDLTA RKLFPALYNL TKEGRLSENF VCVGFARRPK
     SHEQFREEMR QAIQNFSHSS EIDIRVWESL EHRIFYHQAN FSEAEGYSSL RSFLESVDQK
     YGTKGNRLFY LSTPPDYFQE IIRNLNRHQL FYHEQGAQQP WSRLIIEKPF GVDLQTAQEL
     QQCIDANINE ESVYRIDHYL GKETVQNILT IRFANTLFES CWNSQYIDHV QISVSESIGI
     GSRGNFFEKS GMLRDMVQNH LMQLLCLLTM EPPSEFSSAE IKKEKIKILK KILPIREEDV
     IRGQYGEGVV QGVSVSGYRE EENVDPNSLV ETYVALKLFI DNPRWKGVPF YLQAGKRLPK
     RTTDIAVIFK KSSYDLFNSE NCPLCPLEND LLIIRIQPDE GVALQFNCKV PGTNKLVRPV
     KMDFRYDSYF NTVTPEAYER LLCDCILGDR TLFTSNEEVL ASWELFSPLL EQWSKIRPIF
     PNYIAGSLRP QGADELLSRD GRAWRSY
//