ID   AK_CHLMU                Reviewed;         437 AA.
AC   Q9PK32;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-NOV-2008, entry version 43.
DE   RecName: Full=Aspartokinase;
DE            EC=2.7.2.4;
DE   AltName: Full=Aspartate kinase;
GN   Name=lysC; OrderedLocusNames=TC_0641;
OS   Chlamydia muridarum.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia.
OX   NCBI_TaxID=83560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   MEDLINE=20150255; PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA   White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA   Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA   Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA   McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT   pneumoniae AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
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DR   EMBL; AE002160; AAF39470.1; -; Genomic_DNA.
DR   PIR; D81681; D81681.
DR   RefSeq; NP_297015.1; -.
DR   GeneID; 1246002; -.
DR   GenomeReviews; AE002160_GR; TC_0641.
DR   KEGG; cmu:TC0641; -.
DR   TIGR; TC_0641; -.
DR   HOGENOM; Q9PK32; -.
DR   BioCyc; CMUR243161:TC_0641-MON; -.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:InterPro.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR001341; Asp_kin_reg.
DR   Gene3D; G3DSA:3.40.1160.10; Aa_kinase; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome;
KW   Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis;
KW   Transferase.
FT   CHAIN         1    437       Aspartokinase.
FT                                /FTId=PRO_0000066673.
SQ   SEQUENCE   437 AA;  47795 MW;  3E74D659E04906FA CRC64;
     MFKEKKAPLV CKFGGTSVGT SSSIQRVCEI IRKEKPSFVV VSAVAGVTDL LEEFCRAPVG
     QKSQFTAMIR EKHESIAKEL GIDVAIEPFL GPLKQFEGAG HLQQEDQAKI LAIGEDLSAS
     LICSYCRANS LQLEQLEARQ VILTDSQFLR AEPDLALMQT MWGELVLKEN TIYLMQGFLG
     ATASGATTVL GRGGSDFSAS LVGELCEARE LRIYTDVRGV HTADPKILKD TQLIDFLTFE
     EMQELASSGS KVLHQDMLKP CIRAKVPIFV TSTFDLTKEG TWICASLNEG VEGPEIKALS
     LKANQALWFV EYHSPLMRLE NVLRCVRGLG SIPGVVMAQN SGVYFTVDWE ENNQSMTEAL
     REFGAVSCEG PVSLVALVGA KLTSWSMTGV FDALQGTPVL YWSQTDTVIN LIINEESGVV
     VTKLLHDYVL GLNRSGL
//