FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H₂O = L-methionine (S)-S-oxide + thioredoxin.
INTERACTION:
Q0P8E9:flgK; NbExp=1; IntAct=EBI-1191927, EBI-1191246;
SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AL111168; CAL34782.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D81412; D81412.

3D structure databases

HSSP

P54149; 1FVG. [HSSP ENTRY / PDB]

ModBase

Q9PHN0.

Protein-protein interaction databases

IntAct

Q9PHN0; -.

Enzyme and pathway databases

BioCyc

CJEJ192222:CJ0637C-MON; -.

Ontologies

GO:0008113;	Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006464;	Biological process: protein modification process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01401; -; 1.
PBIL [Tree]

InterPro

IPR002569; MsrA.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.1060.10; MsrA; 1.

Pfam

PF01625; PMSR; 1.
Pfam graphical view of domain structure.

ProDom

PD003489; PMSR; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00401; msrA; 1.

ProtoNet

Q9PHN0.

Genome annotation databases

GenomeReviews

AL111168_GR; Cj0637c.

KEGG

cje:Cj0637c; -.

CMR

Q9PHN0; Cj0637c.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 165`	`165`	`Peptide methionine sulfoxide reductase msrA.`	`PRO_0000138534`
`ACT_SITE`	`10 10`		`By similarity.`

Sequence information

Length: 165 AA [This is the length of the unprocessed precursor]

Molecular weight: 18896 Da [This is the MW of the unprocessed precursor]

CRC64: 8DF4366859BF4F13 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKNIVLGGGC FWCVEAVFER LKGVINTEVG YSGGKPNPSY ESVCNGDGNI EVVKINYDEK 

        70         80         90        100        110        120 
QISLLEILTL FFKIHDPTSI DKQGGDIGIQ YRSIIFYENE EDKILAQNFI EEQQKIFSKK 

       130        140        150        160 
IVTKISRLQT YYKAENYHQH YFINNPDQGY CQAVIAPKLQ KIQSD

Q9PHN0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools