ID   GGPPS_RHIRA             Reviewed;         303 AA.
AC   Q9P885;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-NOV-2008, entry version 31.
DE   RecName: Full=Geranylgeranyl pyrophosphate synthetase;
DE            Short=GGPP synthetase;
DE            Short=GGPPSase;
DE   AltName: Full=Geranylgeranyl diphosphate synthase;
DE   Includes:
DE     RecName: Full=Dimethylallyltranstransferase;
DE              EC=2.5.1.1;
DE   Includes:
DE     RecName: Full=Geranyltranstransferase;
DE              EC=2.5.1.10;
DE   Includes:
DE     RecName: Full=Farnesyltranstransferase;
DE              EC=2.5.1.29;
GN   Name=carG;
OS   Rhizomucor racemosus (Mucor circinelloides f. lusitanicus).
OC   Eukaryota; Fungi; Fungi incertae sedis; Basal fungal lineages;
OC   Mucoromycotina; Mucorales; Mucoraceae; Mucor.
OX   NCBI_TaxID=4841;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY, PATHWAY, AND
RP   INDUCTION.
RC   STRAIN=ATCC 1216b / CBS 277.49 / NRRL 3631; TISSUE=Mycelium;
RX   PubMed=12695851; DOI=10.1007/s00294-003-0376-5;
RA   Velayos A., Papp T., Aguilar-Elena R., Fuentes-Vicente M.,
RA   Eslava A.P., Iturriaga E.A., Alvarez M.I.;
RT   "Expression of the carG gene, encoding geranylgeranyl pyrophosphate
RT   synthase, is up-regulated by blue light in Mucor circinelloides.";
RL   Curr. Genet. 43:112-120(2003).
CC   -!- FUNCTION: Catalyzes the trans-addition of the three molecules of
CC       IPP onto DMAPP to form geranylgeranyl pyrophosphate.
CC   -!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
CC       diphosphate = diphosphate + geranyl diphosphate.
CC   -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
CC       = diphosphate + trans,trans-farnesyl diphosphate.
CC   -!- CATALYTIC ACTIVITY: Trans,trans-farnesyl diphosphate + isopentenyl
CC       diphosphate = diphosphate + geranylgeranyl diphosphate.
CC   -!- PATHWAY: Isoprenoid biosynthesis; farnesyl-PP biosynthesis;
CC       farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1.
CC   -!- PATHWAY: Isoprenoid biosynthesis; geranyl-PP biosynthesis;
CC       geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.
CC   -!- PATHWAY: Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis;
CC       geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- INDUCTION: By blue light.
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthetase family.
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DR   EMBL; AJ276129; CAB89115.1; -; Genomic_DNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005625; C:soluble fraction; ISS:UniProtKB.
DR   GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:EC.
DR   GO; GO:0004311; F:farnesyltranstransferase activity; IDA:UniProtKB.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IEA:EC.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IDA:UniProtKB.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR017446; Polyprenyl_synth-rel.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
DR   PANTHER; PTHR12001; Polyprenyl_synt; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHET_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHET_2; 1.
PE   1: Evidence at protein level;
KW   Carotenoid biosynthesis; Cytoplasm; Isoprene biosynthesis;
KW   Multifunctional enzyme; Transferase.
FT   CHAIN         1    303       Geranylgeranyl pyrophosphate synthetase.
FT                                /FTId=PRO_0000123967.
FT   ACT_SITE    156    156       By similarity.
SQ   SEQUENCE   303 AA;  34787 MW;  D440757CA7D0E215 CRC64;
     MLNSHNRTEE RSTEDIILEP YTYLISQPGK DIRAKLISAF DLWLHVPKDV LCVINKIIGM
     LHNASLMIDD VQDDSDLRRG VPVAHHIYGV PQTINTANYV IFLALQEVMK LNIPSMMQVC
     TEELINLHRG QGIELYWRDS LTCPTEEEYI DMVNNKTSGL LRLAVRLMQA ASESDIDYTP
     LVNIIGIHFQ VRDDYMNLQS TSYTNNKGFC EDLTEGKFSF PIIHAIRKDP SNRQLLNIIS
     QKPTSIEVKK YALEVIRKAG SFEYVREFLR QKEAESLKEI KRLGGNPLLE KYIETIRVEA
     TND
//