NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY, PATHWAY, AND INDUCTION.
STRAIN=ATCC 1216b / CBS 277.49 / NRRL 3631;
TISSUE=Mycelium;
DOI=10.1007/s00294-003-0376-5; PubMed=12695851 [NCBI, ExPASy, EBI, Israel, Japan]
Velayos A., Papp T., Aguilar-Elena R., Fuentes-Vicente M., Eslava A.P., Iturriaga E.A., Alvarez M.I.;
"Expression of the carG gene, encoding geranylgeranyl pyrophosphate synthase, is up-regulated by blue light in Mucor circinelloides.";
Curr. Genet. 43:112-120(2003).

Comments

FUNCTION: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
CATALYTIC ACTIVITY: Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
PATHWAY: Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1 .
PATHWAY: Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1 .
PATHWAY: Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm.
INDUCTION: By blue light.
SIMILARITY: Belongs to the FPP/GGPP synthetase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ276129; CAB89115.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q9P885.

Ontologies

GO:0005625;	Cellular component: soluble fraction (inferred from sequence or structural similarity from UniProtKB).
GO:0004311;	Molecular function: farnesyltranstransferase activity (inferred from direct assay from UniProtKB).
GO:0016117;	Biological process: carotenoid biosynthetic process (inferred from direct assay from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR000092; Polyprenyl_synt.
IPR017446; Polyprenyl_synth-rel.
IPR008949; Terpenoid_synth.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.600.10; Terpenoid_synth; 1.

PANTHER

PTHR12001; Polyprenyl_synt; 1.

Pfam

PF00348; polyprenyl_synt; 1.
Pfam graphical view of domain structure.

PROSITE

PS00723; POLYPRENYL_SYNTHET_1; 1.
PS00444; POLYPRENYL_SYNTHET_2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carotenoid biosynthesis; Cytoplasm; Isoprene biosynthesis; Multifunctional enzyme; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 303`	`303`	`Geranylgeranyl pyrophosphate synthetase.`	`PRO_0000123967`
`ACT_SITE`	`156 156`		`By similarity.`

Sequence information

Length: 303 AA [This is the length of the unprocessed precursor]

Molecular weight: 34787 Da [This is the MW of the unprocessed precursor]

CRC64: D440757CA7D0E215 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLNSHNRTEE RSTEDIILEP YTYLISQPGK DIRAKLISAF DLWLHVPKDV LCVINKIIGM 

        70         80         90        100        110        120 
LHNASLMIDD VQDDSDLRRG VPVAHHIYGV PQTINTANYV IFLALQEVMK LNIPSMMQVC 

       130        140        150        160        170        180 
TEELINLHRG QGIELYWRDS LTCPTEEEYI DMVNNKTSGL LRLAVRLMQA ASESDIDYTP 

       190        200        210        220        230        240 
LVNIIGIHFQ VRDDYMNLQS TSYTNNKGFC EDLTEGKFSF PIIHAIRKDP SNRQLLNIIS 

       250        260        270        280        290        300 
QKPTSIEVKK YALEVIRKAG SFEYVREFLR QKEAESLKEI KRLGGNPLLE KYIETIRVEA 


TND

Q9P885 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools