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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V.,
Gwilliam R.,
Rajandream M.A.,
Lyne M.H.,
Lyne R.,
Stewart A.,
Sgouros J.G.,
Peat N.,
Hayles J.,
Baker S.G.,
Basham D.,
Bowman S.,
Brooks K.,
Brown D.,
Brown S.,
Chillingworth T.,
Churcher C.M.,
Collins M.,
Connor R., ![]()
Cronin A.,
Davis P.,
Feltwell T.,
Fraser A.,
Gentles S.,
Goble A.,
Hamlin N.,
Harris D.E.,
Hidalgo J.,
Hodgson G.,
Holroyd S.,
Hornsby T.,
Howarth S.,
Huckle E.J.,
Hunt S.,
Jagels K.,
James K.D.,
Jones L.,
Jones M.,
Leather S.,
McDonald S.,
McLean J.,
Mooney P.,
Moule S.,
Mungall K.L.,
Murphy L.D.,
Niblett D.,
Odell C.,
Oliver K.,
O'Neil S.,
Pearson D.,
Quail M.A.,
Rabbinowitsch E.,
Rutherford K.M.,
Rutter S.,
Saunders D.,
Seeger K.,
Sharp S.,
Skelton J.,
Simmonds M.N.,
Squares R.,
Squares S.,
Stevens K.,
Taylor K.,
Taylor R.G.,
Tivey A.,
Walsh S.V.,
Warren T.,
Whitehead S.,
Woodward J.R.,
Volckaert G.,
Aert R.,
Robben J.,
Grymonprez B.,
Weltjens I.,
Vanstreels E.,
Rieger M.,
Schaefer M.,
Mueller-Auer S.,
Gabel C.,
Fuchs M.,
Duesterhoeft A.,
Fritzc C.,
Holzer E.,
Moestl D.,
Hilbert H.,
Borzym K.,
Langer I.,
Beck A.,
Lehrach H.,
Reinhardt R.,
Pohl T.M.,
Eger P.,
Zimmermann W.,
Wedler H.,
Wambutt R.,
Purnelle B.,
Goffeau A.,
Cadieu E.,
Dreano S.,
Gloux S.,
Lelaure V.,
Mottier S.,
Galibert F.,
Aves S.J.,
Xiang Z.,
Hunt C.,
Moore K.,
Hurst S.M.,
Lucas M.,
Rochet M.,
Gaillardin C.,
Tallada V.A.,
Garzon A.,
Thode G.,
Daga R.R.,
Cruzado L.,
Jimenez J.,
Sanchez M.,
del Rey F.,
Benito J.,
Dominguez A.,
Revuelta J.L.,
Moreno S.,
Armstrong J.,
Forsburg S.L.,
Cerutti L.,
Lowe T.,
McCombie W.R.,
Paulsen I.,
Potashkin J.,
Shpakovski G.V.,
Ussery D.,
Barrell B.G.,
Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
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- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits (By similarity).
- SUBCELLULAR LOCATION: Nucleus, nucleolus (By similarity).
- SIMILARITY: Belongs to the RNA polymerase beta chain family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1227 AA [This is the length of the unprocessed precursor] |
Molecular weight: 137740 Da [This is the MW of the unprocessed precursor] |
CRC64: 614A45ADE74D3419 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MNNAILLHIP HFSALMFKPF YRFSLKLVKC SLNAQFSMNI AGVLRQNFLC KPGMSFQTLE
70 80 90 100 110 120
RERTFKNPPK DGTSFPDLQK AVKPHVDSFN ALTNAGLLNY AVKEIGEKCA FDSITQEEGG
130 140 150 160 170 180
ALKFGNKISF RVDEVQIAKP MLSSRERSSI NRKVYPAEAR ERLTTYKSRL VLKFSWSVNG
190 200 210 220 230 240
GPRQSEMREV GMIPIMVRSN RCHLEGLSPA ELIAHKEESE EMGGYFIVNG IEKLIRMLIL
250 260 270 280 290 300
PKRNHPTAII RPSFANRGTS YSQYGLSIRC VRPDQSSLTN TLHYLNNGVT MFRFHWRKNE
310 320 330 340 350 360
YLIPSMMILK ALLETSDKEI FEGIVGKDLG NTFLTDRVEL MLRAYKSYGL YSQTETLQYL
370 380 390 400 410 420
GSKFRVVLGV AEDLTDVEVG RFLLQKVVLV HLREAKDKFR LLLFMIRKLY ALVAGECCAD
430 440 450 460 470 480
NPDSPQHQEI LLGGFLYGQI LKEKIEDWLN SIRAQINLDV RRSAPGVDFS DRKYLTRVFS
490 500 510 520 530 540
KINNDIGTKL QYFLSTGNLV SNTGLDLQQA TGYTVVAEKL NFYRFLSHFR MVHRGAFFAE
550 560 570 580 590 600
LKTTTVRKLL PEAWGFMCPV HTPDGSPCGL LNHLARKCEI VTHPSDVSQI PSLLLSLGVD
610 620 630 640 650 660
PPSVVGHESG WGCVQLDGKI VGWCTYKLAK HVADVLRLMK IEYAVKLRNG TATEPAKVPL
670 680 690 700 710 720
DLEIGYVPPS HNGQYPGLYL FSNPARMVRP VKHISTGELD MLGPFEQVYM DIACFPKEIV
730 740 750 760 770 780
PKVSTHVEYS PTNVLSIVAN MTPFSDFNQS PRNMYQCQMG KQTMGTPGTA LRYRTDNKLY
790 800 810 820 830 840
RLQTGQTPVV RPKLHNTYGL DHYPNGTNAV VAVISYTGYD MEDAMILNKS AHERGFGYGT
850 860 870 880 890 900
VYKGESFDLS QKRRRGEPVV HHFGFAPGST PRREWLQKLD ADGLPFIGIK LEDGDPIVAY
910 920 930 940 950 960
YDESTGQNFI ETYHGTEPGF VDEVRLLGND VGDSECQQIH VKLRITRSPI IGDKFSSRHG
970 980 990 1000 1010 1020
QKGICSQKWP TVDMPFTESG MQPDIIINPH AFPSRMTIGM FIESLAGKAG ACHGLAQDST
1030 1040 1050 1060 1070 1080
PFIYSEQQTA ADYFGEQLVK AGYNYHGNEP MYSGITGQEM KADIYIGVVY YQRLRHMVSD
1090 1100 1110 1120 1130 1140
KFQVRTTGPI HNLTRQPVKG RKRAGGIRFG EMERDAVIGH GTSFLMQDRL MNCSDYAQSW
1150 1160 1170 1180 1190 1200
VCRDCGSIIS IMSTISMNGV GSASEVRCRS CAKPALGLED TSDIWQDGSG KKFVGGTNTT
1210 1220
LIALPSVFNY LTAELTAMNI KMMLEVK
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Q9P7X8 in FASTA format |
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