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UniProtKB/Swiss-Prot entry Q9P7H1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CLP1_SCHPO
Primary accession number Q9P7H1
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2002
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 63)
Name and origin of the protein
Protein name Tyrosine-protein phosphatase CDC14 homolog
Synonyms EC 3.1.3.48
CDC fourteen-like phosphatase 1
Gene name
Name: clp1
Synonyms: flp1
ORFNames: SPAC1782.09c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
FUNCTION, SUBCELLULAR LOCATION, AND PHOSPHORYLATION.
PubMed=11683392 [NCBI, ExPASy, EBI, Israel, Japan]
Cueille N., Salimova E., Esteban V., Blanco M., Moreno S., Bueno A., Simanis V.;
"Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis.";
J. Cell Sci. 114:2649-2664(2001).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-453; SER-468; SER-470 AND SER-513, AND MASS SPECTROMETRY.
DOI=10.1021/pr7006335; PubMed=18257517 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329670; CAB76271.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T50099; T50099.
RefSeq NP_594716.1; -.
3D structure databases
HSSP P29350; 1GWZ. [HSSP ENTRY / PDB]
ModBase Q9P7H1.
Protein-protein interaction databases
IntAct Q9P7H1; -.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-002796-MON; -.
Organism-specific databases
GeneDB_Spombe SPAC1782.09c; -.
Gene expression databases
ArrayExpress Q9P7H1; -.
Ontologies
GO
GO:0005730; Cellular component: nucleolus (inferred from direct assay from GeneDB_SPombe).
GO:0005816; Cellular component: spindle pole body (inferred from direct assay from GeneDB_SPombe).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004864; Molecular function: protein phosphatase inhibitor activity (inferred from genetic interaction from GeneDB_SPombe).
GO:0004725; Molecular function: protein tyrosine phosphatase activity (inferred from electronic annotation from InterPro).
GO:0008138; Molecular function: protein tyrosine/serine/threonine phosphatase activity (inferred from electronic annotation from InterPro).
GO:0008608; Biological process: attachment of spindle microtubules to kinetochore (inferred from genetic interaction from GeneDB_SPombe).
GO:0031565; Biological process: cytokinesis checkpoint (inferred from mutant phenotype from GeneDB_SPombe).
GO:0000086; Biological process: G2/M transition of mitotic cell cycle (inferred from mutant phenotype from GeneDB_SPombe).
GO:0045736; Biological process: negative regulation of cyclin-dependent protein kinase activity (inferred from genetic interaction from GeneDB_SPombe).
GO:0031031; Biological process: positive regulation of septation initiation signaling (traceable author statement from GeneDB_SPombe).
GO:0006470; Biological process: protein amino acid dephosphorylation (inferred from electronic annotation from InterPro).
GO:0031134; Biological process: sister chromatid biorientation (inferred from mutant phenotype from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR000387; Tyr_Pase.
IPR016130; Tyr_Pase_AS.
IPR000340; Tyr_Pase_dual_specific.
IPR000242; Tyr_Pase_rcpt/non-rcpt.
Graphical view of domain structure.
Pfam PF00782; DSPc; 1.
Pfam graphical view of domain structure.
PRINTS PR00700; PRTYPHPHTASE.
PROSITE PS00383; TYR_PHOSPHATASE_1; 1.
PS50056; TYR_PHOSPHATASE_2; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q9P7H1.
Genome annotation databases
GeneID 2542358; -.
KEGG spo:SPAC1782.09c; -.
NMPDR fig|4896.1.peg.4686; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell cycle; Cell division; Complete proteome; Hydrolase; Mitosis; Nucleus; Phosphoprotein; Protein phosphatase; Septation.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   537  537     Tyrosine-protein phosphatase CDC14 homolog. PRO_0000094874
ACT_SITE   286   286        Phosphocysteine intermediate (By similarity). 
MOD_RES   453   453        Phosphothreonine. 
MOD_RES   468   468        Phosphoserine. 
MOD_RES   470   470        Phosphoserine. 
MOD_RES   513   513        Phosphoserine. 
Sequence information
Length: 537 AA [This is the length of the unprocessed precursor] Molecular weight: 60253 Da [This is the MW of the unprocessed precursor] CRC64: F5E50A8C0924C7EA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDYQDDGLGE MIEFLEDKLY YTSLSQPPKA ELYPHMHFFT IDDELIYNPF YHDFGPLNVS 

        70         80         90        100        110        120 
HLIRFAVIVH GIMGKHRQAK KSKAIVLYSS TDTRLRANAA CLLACYMVLV QNWPPHLALA 

       130        140        150        160        170        180 
PLAQAEPPFL GFRDAGYAVS DYYITIQDCV YGLWRARESS ILNIRNIDVH DYETYERVEN 

       190        200        210        220        230        240 
GDFNWISPKF IAFASPIQAG WNHASTRPKK LPQPFAIVLD YFVANKVKLI VRLNGPLYDK 

       250        260        270        280        290        300 
KTFENVGIRH KEMYFEDGTV PELSLVKEFI DLTEEVEEDG VIAVHCKAGL GRTGCLIGAY 

       310        320        330        340        350        360 
LIYKHCFTAN EVIAYMRIMR PGMVVGPQQH WLHINQVHFR AYFYEKAMGR AIQQATAAEP 

       370        380        390        400        410        420 
LATPPRHPLN ATNGTSQSNI STPLPEPTPG QPRKVSGHNP PSARRLPSAS SVKFNEKLKN 

       430        440        450        460        470        480 
ASKQSIQNEN KASYSSYEDS EIQNDDETRT VGTPTETISV VRLRRSSSQS NIEPNGVRSP 

       490        500        510        520        530 
TSSPTGSPIR RTSGNRWSSG SSHSKKSAQR SVSMSSLNNT SNGRVAKPKP SKSRLIS 

Q9P7H1 in FASTA format

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