[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Horst U3; Eastwood D.C., Bains N.K., Henderson J., Burton K.S.; "Genomic sequencing of superoxide dismutase in Agaricus bisporus."; Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
PATHWAY: Pyrimidine metabolism; dTTP biosynthesis .
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the thymidylate synthase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ401221; CAB96042.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P04818; 1HW4. [HSSP ENTRY / PDB]

ModBase

Q9P4T7.

Ontologies

GO:0004799;	Molecular function: thymidylate synthase activity (inferred from electronic annotation from InterPro).
GO:0006231;	Biological process: dTMP biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000398; Thymidylat_synth_C.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.572.10; Thymidylat_synth_C; 1.

PANTHER

PTHR11549:SF2; Thymidylat_synth_C; 1.

Pfam

PF00303; Thymidylat_synt; 1.
Pfam graphical view of domain structure.

PRINTS

PR00108; THYMDSNTHASE.

ProDom

PD001180; Thymidylat_synth; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03284; thym_sym; 1.

PROSITE

PS00091; THYMIDYLATE_SYNTHASE; 1.

ProtoNet

Q9P4T7.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Methyltransferase; Nucleotide biosynthesis; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 296`	`296`	`Thymidylate synthase.`	`PRO_0000140908`
`ACT_SITE`	`171 171`		`By similarity.`

Sequence information

Length: 296 AA [This is the length of the unprocessed precursor]

Molecular weight: 33679 Da [This is the MW of the unprocessed precursor]

CRC64: 8FB8A8989D4A952A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHDEDQYLHL IRRVLDTGDL RPDRTGTGTI SLFAPPNLRF SLRESTVPLL TTKRTFLRGI 

        70         80         90        100        110        120 
VEELLWFTNG LTDSKILSDK GVKIWDGNGS KAFLESRGLG HRREGDLGPV YGFQWRHFGA 

       130        140        150        160        170        180 
EYEDCDADYA GKGVDQLREC IRKIKENPTD RRIILSAWNP KDIPSMALPP CHMLCQFYVH 

       190        200        210        220        230        240 
LPADTAKPEL SCLMFQRSAD LGLGIPFNIA SYALLTHMIA HVTGTTAREL IIQLGDAHVY 

       250        260        270        280        290 
RDHVEALEVQ LQREPRPFPK LRWARDGITD IEDFEYSDFV IEGYNPHPSI AMKMSV

Q9P4T7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools