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UniProtKB/Swiss-Prot entry Q9P2S5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name WDR8_HUMAN
Primary accession number Q9P2S5
Secondary accession numbers Q5T0D6 Q9BUH7 Q9NTK7 Q9NX56
Integrated into Swiss-Prot on September 26, 2001
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 61)
Name and origin of the protein
Protein name WD repeat-containing protein 8
Synonyms None
Gene name
Name: WDR8
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1006/geno.2000.6475; PubMed=11401440 [NCBI, ExPASy, EBI, Israel, Japan]
Koshizuka Y., Ikegawa S., Sano M., Nakamura K., Nakamura Y.;
"Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family.";
Genomics 72:252-259(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Carcinoma;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Lung, and Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB034912; BAA92312.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK000437; BAA91164.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL513320; CAI14335.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136528; CAI14335.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL513320; CAI14336.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136528; CAI14336.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136528; CAI19128.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL513320; CAI19128.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL136528; CAI19129.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL513320; CAI19129.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002611; AAH02611.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC086311; AAH86311.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_060288.2; -.
UniGene Hs.31714
3D structure databases
ModBase Q9P2S5.
Protein-protein interaction databases
IntAct Q9P2S5; -.
PTM databases
PhosphoSite Q9P2S5; -.
Organism-specific databases
H-InvDB HIX0020054; -.
HGNC HGNC:12759; WDR8.
GenAtlas WDR8.
MIM 606040; gene. [NCBI / EBI]
PharmGKB PA37363; -.
GeneCards Q9P2S5.
Gene expression databases
ArrayExpress Q9P2S5; -.
CleanEx HS_WDR8; -.
GermOnline ENSG00000116213; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR015943; WD40/YVTN_repeat-like.
IPR001680; WD40_repeat.
Graphical view of domain structure.
Gene3D G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 2.
Pfam PF00400; WD40; 1.
Pfam graphical view of domain structure.
SMART SM00320; WD40; 4.
SMART graphical view of domain structure.
PROSITE PS00678; WD_REPEATS_1; FALSE_NEG.
PS50082; WD_REPEATS_2; FALSE_NEG.
PS50294; WD_REPEATS_REGION; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q9P2S5.
Genome annotation databases
Ensembl ENSG00000116213; Homo sapiens. [Contig view]
GeneID 49856; -.
KEGG hsa:49856; -.
Phylogenomic databases
HOGENOM Q9P2S5; -.
HOVERGEN Q9P2S5; -.
Other
NextBio 53024; -.
SOURCE WDR8; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cytoplasm; Repeat; WD repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   460  460     WD repeat-containing protein 8. PRO_0000051356
REPEAT   46    86  41     WD 1. 
REPEAT   89   129  41     WD 2. 
REPEAT   176   210  35     WD 3. 
REPEAT   221   260  40     WD 4. 
REPEAT   328   369  42     WD 5. 
REPEAT   371   410  40     WD 6. 
VAR_SEQ   415   460        DFAVLSLCWHLSGDSMALLSKDHFCLCFLETEAVVGTACR QLGGHT -> KHIPEATDVAALLCAVWHHTG (in isoform 2). VSP_016112
CONFLICT   381   381        W -> R (in Ref. 2; BAA91164). 
CONFLICT   405   405        C -> R (in Ref. 2; BAA91164). 
Sequence information
Length: 460 AA [This is the length of the unprocessed precursor] Molecular weight: 51588 Da [This is the MW of the unprocessed precursor] CRC64: C2E318B1F06F79BF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNFSEVFKLS SLLCKFSPDG KYLASCVQYR LVVRDVNTLQ ILQLYTCLDQ IQHIEWSADS 

        70         80         90        100        110        120 
LFILCAMYKR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS PDGRHILNTT EFHLRITVWS 

       130        140        150        160        170        180 
LCTKSVSYIK YPKACLQGIT FTRDGRYMAL AERRDCKDYV SIFVCSDWQL LRHFDTDTQD 

       190        200        210        220        230        240 
LTGIEWAPNG CVLAVWDTCL EYKILLYSLD GRLLSTYSAY EWSLGIKSVA WSPSSQFLAV 

       250        260        270        280        290        300 
GSYDGKVRIL NHVTWKMITE FGHPAAINDP KIVVYKEAEK SPQLGLGCLS FPPPRAGAGP 

       310        320        330        340        350        360 
LPSSESKYEI ASVPVSLQTL KPVTDRANPK IGIGMLAFSP DSYFLATRND NIPNAVWVWD 

       370        380        390        400        410        420 
IQKLRLFAVL EQLSPVRAFQ WDPQQPRLAI CTGGSRLYLW SPAGCMSVQV PGEGDFAVLS 

       430        440        450        460 
LCWHLSGDSM ALLSKDHFCL CFLETEAVVG TACRQLGGHT
Q9P2S5 in FASTA format

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