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UniProtKB/Swiss-Prot entry Q9P241


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AT10D_HUMAN
Primary accession number Q9P241
Secondary accession numbers Q8NC70 Q96SR3
Integrated into Swiss-Prot on October 18, 2001
Sequence was last modified on March 25, 2003 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 69)
Name and origin of the protein
Protein name Probable phospholipid-transporting ATPase VD
Synonyms ATPVD
EC 3.6.3.1
Gene name
Name: ATP10D
Synonyms: KIAA1487
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Monocyte;
DOI=10.1007/s00335-002-3032-3; PubMed=12532265 [NCBI, ExPASy, EBI, Israel, Japan]
Flamant S., Pescher P., Lemercier B., Clement-Ziza M., Kepes F., Fellous M., Milon G., Marchal G., Besmond C.;
"Characterization of a putative type IV aminophospholipid transporter P-type ATPase.";
Mamm. Genome 14:21-30(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 354-1426 (ISOFORM 2).
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 777-1426, AND VARIANT THR-1389.
TISSUE=Brain;
DOI=10.1093/dnares/7.2.143; PubMed=10819331 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 7:143-150(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ441078; CAD29577.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK027598; BAB55221.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK074930; BAC11299.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB040920; BAA96011.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_065186.2; -.
UniGene Hs.437241
3D structure databases
ModBase Q9P241.
PTM databases
PhosphoSite Q9P241; -.
Organism-specific databases
HGNC HGNC:13549; ATP10D.
GenAtlas ATP10D.
PharmGKB PA25100; -.
GeneCards Q9P241.
HUGE KIAA1487.
Gene expression databases
ArrayExpress Q9P241; -.
CleanEx HS_ATP10D; -.
GermOnline ENSG00000145246; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0005524; Molecular function: ATP binding (non-traceable author statement from UniProtKB).
GO:0015662; Molecular function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (non-traceable author statement from UniProtKB).
GO:0004012; Molecular function: phospholipid-translocating ATPase activity (non-traceable author statement from UniProtKB).
GO:0006812; Biological process: cation transport (non-traceable author statement from UniProtKB).
GO:0015914; Biological process: phospholipid transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001757; ATPase_P.
IPR006539; Flippase.
IPR013200; HAD-SF_hydro-like_3.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF08282; Hydrolase_3; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
TIGRFAMs TIGR01652; ATPase-Plipid; 1.
TIGR01494; ATPase_P-type; 3.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet Q9P241.
Genome annotation databases
Ensembl ENSG00000145246; Homo sapiens. [Contig view]
GeneID 57205; -.
KEGG hsa:57205; -.
Phylogenomic databases
HOGENOM Q9P241; -.
HOVERGEN Q9P241; -.
Other
LinkHub Q9P241; -.
NextBio 63294; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Hydrolase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1426  1426     Probable phospholipid-transporting ATPase VD. PRO_0000046382
TOPO_DOM   1     97  97     Cytoplasmic (Potential). 
TRANSMEM   98    118  21     Potential. 
TOPO_DOM   119    121  3     Extracellular (Potential). 
TRANSMEM   122    142  21     Potential. 
TOPO_DOM   143    321  179     Cytoplasmic (Potential). 
TRANSMEM   322    342  21     Potential. 
TOPO_DOM   343    365  23     Extracellular (Potential). 
TRANSMEM   366    386  21     Potential. 
TOPO_DOM   387   1113  727     Cytoplasmic (Potential). 
TRANSMEM   1114   1134  21     Potential. 
TOPO_DOM   1135   1145  11     Extracellular (Potential). 
TRANSMEM   1146   1166  21     Potential. 
TOPO_DOM   1167   1195  29     Cytoplasmic (Potential). 
TRANSMEM   1196   1216  21     Potential. 
TOPO_DOM   1217   1224  8     Extracellular (Potential). 
TRANSMEM   1225   1245  21     Potential. 
TOPO_DOM   1246   1252  7     Cytoplasmic (Potential). 
TRANSMEM   1253   1273  21     Potential. 
TOPO_DOM   1274   1292  19     Extracellular (Potential). 
TRANSMEM   1293   1313  21     Potential. 
TOPO_DOM   1314   1426  113     Cytoplasmic (Potential). 
NP_BIND   996   1003  8     ATP (Potential). 
NP_BIND   1364   1371  8     ATP (Potential). 
ACT_SITE   438    438        4-aspartylphosphate intermediate (By similarity). 
METAL   1056   1056        Magnesium (By similarity). 
METAL   1060   1060        Magnesium (By similarity). 
VAR_SEQ   553    747        Missing (in isoform 2). VSP_006954
VARIANT   1240   1240  1     V -> I (in dbSNP:rs1058793 [NCBI]). VAR_020187 
VARIANT   1389   1389  1     S -> T (in dbSNP:rs4145944 [NCBI]). VAR_024371 
CONFLICT   1002   1002        R -> K (in Ref. 2 and 3). 
CONFLICT   1090   1090        Y -> S (in Ref. 2 and 3). 
Sequence information
Length: 1426 AA [This is the length of the unprocessed precursor] Molecular weight: 160320 Da [This is the MW of the unprocessed precursor] CRC64: 5A260F1537ADD705 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTEALQWARY HWRRLIRGAT RDDDSGPYNY SSLLACGRKS SQTPKLSGRH RIVVPHIQPF 

        70         80         90        100        110        120 
KDEYEKFSGA YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN LYFLFLVVLN WVPLVEAFQK 

       130        140        150        160        170        180 
EITMLPLVVV LTIIAIKDGL EGYRKYKIDK QINNLITKVY SRKEKKYIDR CWKDVTVGDF 

       190        200        210        220        230        240 
IRLSCNEVIP ADMVLLFSTD PDGICHIETS GLDGESNLKQ RQVVRGYAEQ DSEVDPEKFS 

       250        260        270        280        290        300 
SRIECESPNN DLSRFRGFLE HSNKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA 

       310        320        330        340        350        360 
MLNNSGPRYK RSKLERRANT DVLWCVMLLV IMCLTGAVGH GIWLSRYEKM HFFNVPEPDG 

       370        380        390        400        410        420 
HIISPLLAGF YMFWTMIILL QVLIPISLYV SIEIVKLGQI YFIQSDVDFY NEKMDSIVQC 

       430        440        450        460        470        480 
RALNIAEDLG QIQYLFSDKT GTLTENKMVF RRCSVAGFDY CHEENARRLE SYQEAVSEDE 

       490        500        510        520        530        540 
DFIDTVSGSL SNMAKPRAPS CRTVHNGPLG NKPSNHLAGS SFTLGSGEGA SEVPHSRQAA 

       550        560        570        580        590        600 
FSSPIETDVV PDTRLLDKFS QITPRLFMPL DETIQNPPME TLYIIDFFIA LAICNTVVVS 

       610        620        630        640        650        660 
APNQPRQKIR HPSLGGLPIK SLEEIKSLFQ RWSVRRSSSP SLNSGKEPSS GVPNAFVSRL 

       670        680        690        700        710        720 
PLFSRMKPAS PVEEEVSQVC ESPQCSSSSA CCTETEKQHG DAGLLNGKAE SLPGQPLACN 

       730        740        750        760        770        780 
LCYEAESPDE AALVYAARAY QCTLRSRTPE QVMVDFAALG PLTFQLLHIL PFDSVRKRMS 

       790        800        810        820        830        840 
VVVRHPLSNQ VVVYTKGADS VIMELLSVAS PDGASLEKQQ MIVREKTQKH LDDYAKQGLR 

       850        860        870        880        890        900 
TLCIAKKVMS DTEYAEWLRN HFLAETSIDN REELLLESAM RLENKLTLLG ATGIEDRLQE 

       910        920        930        940        950        960 
GVPESIEALH KAGIKIWMLT GDKQETAVNI AYACKLLEPD DKLFILNTQS KDACGMLMST 

       970        980        990       1000       1010       1020 
ILKELQKKTQ ALPEQVSLSE DLLQPPVPRD SGLRAGLIIT GRTLEFALQE SLQKQFLELT 

      1030       1040       1050       1060       1070       1080 
SWCQAVVCCR ATPLQKSEVV KLVRSHLQVM TLAIGDGAND VSMIQVADIG IGVSGQEGMQ 

      1090       1100       1110       1120       1130       1140 
AVMASDFAVY QFKHLSKLLL VHGHWCYTRL SNMILYFFYK NVAYVNLLFW YQFFCGFSGT 

      1150       1160       1170       1180       1190       1200 
SMTDYWVLIF FNLLFTSAPP VIYGVLEKDV SAETLMQLPE LYRSGQKSEA YLPHTFWITL 

      1210       1220       1230       1240       1250       1260 
LDAFYQSLVC FFVPYFTYQG SDTDIFAFGN PLNTAALFIV LLHLVIESKS LTWIHLLVII 

      1270       1280       1290       1300       1310       1320 
GSILSYFLFA IVFGAMCVTC NPPSNPYWIM QEHMLDPVFY LVCILTTSIA LLPRFVYRVL 

      1330       1340       1350       1360       1370       1380 
QGSLFPSPIL RAKHFDRLTP EERTKALKKW RGAGKMNQVT SKYANQSAGK SGRRPMPGPS 

      1390       1400       1410       1420 
AVFAMKSASS CAIEQGNLSL CETALDQGYS ETKAFEMAGP SKGKES 

Q9P241 in FASTA format

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