ID   IFNK_HUMAN              Reviewed;         207 AA.
AC   Q9P0W0; Q5T166;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-NOV-2008, entry version 50.
DE   RecName: Full=Interferon kappa;
DE            Short=IFN-kappa;
DE   Flags: Precursor;
GN   Name=IFNK; ORFNames=UNQ6124/PRO20084;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Cao X., Zhang W.;
RT   "Novel human interferon.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, AND
RP   TISSUE SPECIFICITY.
RX   MEDLINE=21523923; PubMed=11514542; DOI=10.1074/jbc.M102502200;
RA   LaFleur D.W., Nardelli B., Tsareva T., Mather D., Feng P., Semenuk M.,
RA   Taylor K., Buergin M., Chinchilla D., Roshke V., Chen G., Ruben S.M.,
RA   Pitha P.M., Coleman T.A., Moore P.A.;
RT   "Interferon-kappa, a novel type I interferon expressed in human
RT   keratinocytes.";
RL   J. Biol. Chem. 276:39765-39771(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LYS-133.
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [5]
RP   PROTEIN SEQUENCE OF 28-42.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [6]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=12391192;
RA   Nardelli B., Zaritskaya L., Semenuk M., Cho Y.H., LaFleur D.W.,
RA   Shah D., Ullrich S., Girolomoni G., Albanesi C., Moore P.A.;
RT   "Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine
RT   production by cells of the innate immune system.";
RL   J. Immunol. 169:4822-4830(2002).
CC   -!- FUNCTION: May play a role in the regulation of immune cell
CC       function. Cytokine that imparts cellular protection against viral
CC       infection in a species-specific manner. Activates the interferon-
CC       stimulated response element signaling pathway. It is able to
CC       directly modulate cytokine release from monocytes and dendritic
CC       cells. Binds heparin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in keratinocytes, monocytes and in
CC       resting dendritic cells.
CC   -!- INDUCTION: By viral infection, upon exposure to double-stranded
CC       RNA, or upon treatment with either interferon-gamma or interferon-
CC       beta.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
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DR   EMBL; AF146759; AAF67468.1; -; mRNA.
DR   EMBL; AF315688; AAK01623.1; -; mRNA.
DR   EMBL; AF384048; AAK63835.1; -; Genomic_DNA.
DR   EMBL; AY358855; AAQ89214.1; -; mRNA.
DR   EMBL; AL451123; CAI13042.1; -; Genomic_DNA.
DR   RefSeq; NP_064509.2; -.
DR   UniGene; Hs.591083; -.
DR   HSSP; P56828; 1B5L.
DR   PhosphoSite; Q9P0W0; -.
DR   Ensembl; ENSG00000147896; Homo sapiens.
DR   GeneID; 56832; -.
DR   KEGG; hsa:56832; -.
DR   H-InvDB; HIX0034769; -.
DR   HGNC; HGNC:21714; IFNK.
DR   PharmGKB; PA134970126; -.
DR   HOGENOM; Q9P0W0; -.
DR   HOVERGEN; Q9P0W0; -.
DR   NextBio; 62232; -.
DR   ArrayExpress; Q9P0W0; -.
DR   CleanEx; HS_IFNK; -.
DR   GermOnline; ENSG00000147896; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005132; F:interferon-alpha/beta receptor binding; IDA:UniProtKB.
DR   GO; GO:0019221; P:cytokine and chemokine mediated signaling p...; IDA:UniProtKB.
DR   GO; GO:0030101; P:natural killer cell activation; NAS:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; NAS:UniProtKB.
DR   GO; GO:0045089; P:positive regulation of innate immune response; TAS:UniProtKB.
DR   GO; GO:0045449; P:regulation of transcription; IDA:UniProtKB.
DR   GO; GO:0009615; P:response to virus; IEP:UniProtKB.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR000471; Interferon_abd.
DR   Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
DR   PANTHER; PTHR11691; Interferon_abd; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   ProDom; PD000550; Interferon_abd; 1.
DR   SMART; SM00076; IFabd; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Coiled coil; Cytokine; Direct protein sequencing;
KW   Polymorphism; Secreted; Signal.
FT   SIGNAL        1     27
FT   CHAIN        28    207       Interferon kappa.
FT                                /FTId=PRO_0000016410.
FT   COILED      118    148       Potential.
FT   DISULFID     30    128       By similarity.
FT   DISULFID     59    181       By similarity.
FT   VARIANT      97     97       I -> N (in dbSNP:rs34933275).
FT                                /FTId=VAR_032710.
FT   VARIANT     133    133       E -> K (in dbSNP:rs700785).
FT                                /FTId=VAR_021303.
SQ   SEQUENCE   207 AA;  25219 MW;  49CF410ECE52B597 CRC64;
     MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS MSNSFPVECL
     RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ HTFKYWKERH LKQIQIGLDQ
     QAEYLNQCLE EDENENEDMK EMKENEMKPS EARVPQLSSL ELRRYFHRID NFLKEKKYSD
     CAWEIVRVEI RRCLYYFYKF TALFRRK
//